Nature and Nurture: What Determines Tumor Metabolic Phenotypes?
- PMID: 28584183
- DOI: 10.1158/0008-5472.CAN-17-0165
Nature and Nurture: What Determines Tumor Metabolic Phenotypes?
Abstract
Understanding the genetic basis of cancer has led to therapies that _target driver mutations and has helped match patients with more personalized drugs. Oncogenic mutations influence tumor metabolism, but other tumor characteristics can also contribute to their metabolic phenotypes. Comparison of isogenic lung and pancreas tumor models suggests that use of some metabolic pathways is defined by lineage rather than by driver mutation. Lung tumors catabolize circulating branched chain amino acids (BCAA) to extract nitrogen for nonessential amino acid and nucleotide synthesis, whereas pancreatic cancer obtains amino acids from catabolism of extracellular protein. These differences in amino acid metabolism translate into distinct pathway dependencies, as genetic disruption of the enzymes responsible for utilization of BCAA nitrogen limits the growth of lung tumors, but not pancreatic tumors. These data argue that some cancer metabolic phenotypes are defined by cancer tissue-of-origin and environment and that these features constrain the influence of genetic mutations on metabolism. A better understanding of the factors defining tumor nutrient utilization could be exploited to help improve cancer therapy. Cancer Res; 77(12); 3131-4. ©2017 AACR.
©2017 American Association for Cancer Research.
Similar articles
-
Towards a metabolic therapy of cancer?Acta Biomed. 2012 Dec;83(3):168-76. Acta Biomed. 2012. PMID: 23762991 Review.
-
Molecular or Metabolic Reprograming: What Triggers Tumor Subtypes?Cancer Res. 2016 Sep 15;76(18):5195-200. doi: 10.1158/0008-5472.CAN-16-0141. Cancer Res. 2016. PMID: 27635042 Review.
-
The Emerging Hallmarks of Cancer Metabolism.Cell Metab. 2016 Jan 12;23(1):27-47. doi: 10.1016/j.cmet.2015.12.006. Cell Metab. 2016. PMID: 26771115 Free PMC article. Review.
-
_targeting cancer's metabolic co-dependencies: A landscape shaped by genotype and tissue context.Biochim Biophys Acta Rev Cancer. 2018 Aug;1870(1):76-87. doi: 10.1016/j.bbcan.2018.05.002. Epub 2018 May 23. Biochim Biophys Acta Rev Cancer. 2018. PMID: 29775654 Free PMC article. Review.
-
Metabolic network adaptations in cancer as _targets for novel therapies.Biochem Soc Trans. 2010 Oct;38(5):1302-6. doi: 10.1042/BST0381302. Biochem Soc Trans. 2010. PMID: 20863303
Cited by
-
_targeting glutamine utilization to block metabolic adaptation of tumor cells under the stress of carboxyamidotriazole-induced nutrients unavailability.Acta Pharm Sin B. 2022 Feb;12(2):759-773. doi: 10.1016/j.apsb.2021.07.008. Epub 2021 Jul 21. Acta Pharm Sin B. 2022. PMID: 35256945 Free PMC article.
-
m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer.Cell Death Dis. 2022 May 14;13(5):463. doi: 10.1038/s41419-022-04859-w. Cell Death Dis. 2022. PMID: 35568711 Free PMC article.
-
Taking up the reins of power: metabolic functions of p53.J Mol Cell Biol. 2019 Jul 19;11(7):610-614. doi: 10.1093/jmcb/mjz065. J Mol Cell Biol. 2019. PMID: 31282931 Free PMC article. Review. No abstract available.
-
A 13-Gene Metabolic Prognostic Signature Is Associated With Clinical and Immune Features in Stomach Adenocarcinoma.Front Oncol. 2021 Jun 21;11:612952. doi: 10.3389/fonc.2021.612952. eCollection 2021. Front Oncol. 2021. PMID: 34235071 Free PMC article.
-
Androgen Receptor Signaling and Metabolic and Cellular Plasticity During Progression to Castration Resistant Prostate Cancer.Front Oncol. 2020 Oct 9;10:580617. doi: 10.3389/fonc.2020.580617. eCollection 2020. Front Oncol. 2020. PMID: 33163409 Free PMC article. Review.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
