Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician

doi:10.1080/20002297.2017.1332710

Review

. 2017 Jun 14;9(1):1332710.

doi: 10.1080/20002297.2017.1332710. eCollection 2017.

Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician

Palle Holmstrup¹, Christian Damgaard^{1

2}, Ingar Olsen³, Björn Klinge^{4

5}, Allan Flyvbjerg⁶, Claus Henrik Nielsen^{1

2}, Peter Riis Hansen^{1

7}

Affiliations

¹ Section for Periodontology, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
² Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
³ Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
⁴ Department of Periodontology, Faculty of Odontology, Malmö University, Malmö, Sweden.
⁵ Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
⁶ Steno Diabetes Center Copenhagen, Copenhagen, Denmark.
⁷ Cardiology Department, Herlev and Gentofte Hospital, Hellerup, Denmark.

PMID: 28748036
PMCID: PMC5508374
DOI: 10.1080/20002297.2017.1332710

Review

Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician

Palle Holmstrup et al. J Oral Microbiol. 2017.

. 2017 Jun 14;9(1):1332710.

doi: 10.1080/20002297.2017.1332710. eCollection 2017.

Authors

Palle Holmstrup¹, Christian Damgaard^{1

2}, Ingar Olsen³, Björn Klinge^{4

5}, Allan Flyvbjerg⁶, Claus Henrik Nielsen^{1

2}, Peter Riis Hansen^{1

7}

Affiliations

¹ Section for Periodontology, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
² Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
³ Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
⁴ Department of Periodontology, Faculty of Odontology, Malmö University, Malmö, Sweden.
⁵ Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
⁶ Steno Diabetes Center Copenhagen, Copenhagen, Denmark.
⁷ Cardiology Department, Herlev and Gentofte Hospital, Hellerup, Denmark.

PMID: 28748036
PMCID: PMC5508374
DOI: 10.1080/20002297.2017.1332710

Abstract

Increasing evidence has suggested an independent association between periodontitis and a range of comorbidities, for example cardiovascular disease, type 2 diabetes, rheumatoid arthritis, osteoporosis, Parkinson's disease, Alzheimer's disease, psoriasis, and respiratory infections. Shared inflammatory pathways are likely to contribute to this association, but distinct causal mechanisms remain to be defined. Some of these comorbid conditions may improve by periodontal treatment, and a bidirectional relationship may exist, where, for example, treatment of diabetes can improve periodontal status. The present article presents an overview of the evidence linking periodontitis with selected systemic diseases and calls for increased cooperation between dentists and medical doctors to provide optimal screening, treatment, and prevention of both periodontitis and its comorbidities.

Keywords: Alzheimer’s disease; Parkinson’s disease; Periodontitis; cardiovascular disease; comorbidity; low-grade inflammation; osteoporosis; periodontal disease; pneumonia; psoriasis; rheumatoid arthritis; type 2 diabetes.

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References

1. Bartold PM, Van Dyke TE.. Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts. Periodontol. 2000. 2013;62:203–13. - PMC - PubMed
1. Papapanou PN, Lindhe J, Sterrett JD, et al. Considerations on the contribution of ageing to loss of periodontal tissue support. J Clin Periodontol. 1991;18:611–615. - PubMed
1. Dewhirst FE, Chen T, Izard J, et al. The human oral microbiome. J Bacteriol. 2010;192:5002–5017. - PMC - PubMed
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1. Belstrom D, Paster BJ, Fiehn NE, et al. Salivary bacterial fingerprints of established oral disease revealed by the Human Oral Microbe Identification using Next Generation Sequencing (HOMINGS) technique. J Oral Microbiol. 2016;8:30170. - PMC - PubMed

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This work was supported by the European Commission [FP7-HEALTH-306029], Danish Dental Association, Danish Foundation for Mutual Efforts in Dental Care, and Simon Spies Foundation.

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[1] Bartold PM, Van Dyke TE.. Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts. Periodontol. 2000. 2013;62:203–13. - PMC - PubMed

[2] Bartold PM, Van Dyke TE.. Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts. Periodontol. 2000. 2013;62:203–13. - PMC - PubMed

[3] Papapanou PN, Lindhe J, Sterrett JD, et al. Considerations on the contribution of ageing to loss of periodontal tissue support. J Clin Periodontol. 1991;18:611–615. - PubMed

[4] Papapanou PN, Lindhe J, Sterrett JD, et al. Considerations on the contribution of ageing to loss of periodontal tissue support. J Clin Periodontol. 1991;18:611–615. - PubMed

[5] Dewhirst FE, Chen T, Izard J, et al. The human oral microbiome. J Bacteriol. 2010;192:5002–5017. - PMC - PubMed

[6] Dewhirst FE, Chen T, Izard J, et al. The human oral microbiome. J Bacteriol. 2010;192:5002–5017. - PMC - PubMed

[7] Aas JA, Paster BJ, Stokes LN, et al. Defining the normal bacterial flora of the oral cavity. J Clin Microbiol. 2005;43:5721–5732. - PMC - PubMed

[8] Aas JA, Paster BJ, Stokes LN, et al. Defining the normal bacterial flora of the oral cavity. J Clin Microbiol. 2005;43:5721–5732. - PMC - PubMed

[9] Belstrom D, Paster BJ, Fiehn NE, et al. Salivary bacterial fingerprints of established oral disease revealed by the Human Oral Microbe Identification using Next Generation Sequencing (HOMINGS) technique. J Oral Microbiol. 2016;8:30170. - PMC - PubMed

[10] Belstrom D, Paster BJ, Fiehn NE, et al. Salivary bacterial fingerprints of established oral disease revealed by the Human Oral Microbe Identification using Next Generation Sequencing (HOMINGS) technique. J Oral Microbiol. 2016;8:30170. - PMC - PubMed

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Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician

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Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician

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