Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Mar;84(6):1492-6.
doi: 10.1073/pnas.84.6.1492.

Differential regulation of a Thy-1 gene in transgenic mice

G Kollias, E Spanopoulou, F Grosveld, M Ritter, J Beech, R Morris

Differential regulation of a Thy-1 gene in transgenic mice

G Kollias et al. Proc Natl Acad Sci U S A. 1987 Mar.

Abstract

We have generated Thy-1.1-transgenic Thy-1.2 mice to study the developmental expression of the Thy-1 gene in detail by transcriptional and immunological methods. In brain, the expression of the injected gene was identical to that of the endogenous gene in a tissue- and development-specific manner. In lymphoid tissue, the transferred gene was also expressed correctly in the early phases of T-cell lineage development; however, as the T cells matured, the transcription of the transferred gene, but not the endogenous gene, was suppressed. This result shows that different regulatory elements are used to express the Thy-1 gene in early and late lymphoid development.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nature. 1966 Jan 29;209(5022):521-3 - PubMed
    1. J Exp Med. 1964 Sep 1;120:413-33 - PubMed
    1. J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed
    1. Eur J Immunol. 1975 Apr;5(4):274-81 - PubMed
    1. Immunol Rev. 1979;47:63-90 - PubMed

Publication types

LinkOut - more resources

  NODES
twitter 2