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Review
. 2018 Jan 1;26(1):45-56.
doi: 10.4062/biomolther.2017.211.

Oncogene-Driven Metabolic Alterations in Cancer

Hye-Young Min  1   2 , Ho-Young Lee  1   2   3
Affiliations
Review

Oncogene-Driven Metabolic Alterations in Cancer

Hye-Young Min et al. Biomol Ther (Seoul). .

Abstract

Cancer is the leading cause of human deaths worldwide. Understanding the biology underlying the evolution of cancer is important for reducing the economic and social burden of cancer. In addition to genetic aberrations, recent studies demonstrate metabolic rewiring, such as aerobic glycolysis, glutamine dependency, accumulation of intermediates of glycolysis, and upregulation of lipid and amino acid synthesis, in several types of cancer to support their high demands on nutrients for building blocks and energy production. Moreover, oncogenic mutations are known to be associated with metabolic reprogramming in cancer, and these overall changes collectively influence tumor-microenvironment interactions and cancer progression. Accordingly, several agents _targeting metabolic alterations in cancer have been extensively evaluated in preclinical and clinical settings. Additionally, metabolic reprogramming is considered a novel _target to control cancers harboring un-_targetable oncogenic alterations such as KRAS. Focusing on lung cancer, here, we highlight recent findings regarding metabolic rewiring in cancer, its association with oncogenic alterations, and therapeutic strategies to control deregulated metabolism in cancer.

Keywords: Aerobic glycolysis; Cancer; Cancer metabolism; Metabolic reprogramming; Non-small cell lung cancer; Oncogenic alteration.

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Figures

Fig. 1.
Fig. 1.
Metabolic reprogramming in cancer cells compared with normal cells.
Fig. 2.
Fig. 2.
Contribution of genetic alterations to metabolic reprogramming in cancer.
See this image and copyright information in PMC

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