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Review
. 2018 Jul 1;99(1):196-211.
doi: 10.1093/biolre/ioy049.

Hemochorial placentation: development, function, and adaptations

Michael J Soares  1   2 , Kaela M Varberg  1 , Khursheed Iqbal  1
Affiliations
Review

Hemochorial placentation: development, function, and adaptations

Michael J Soares et al. Biol Reprod. .

Abstract

Placentation is a reproductive adaptation that permits fetal growth and development within the protected confines of the female reproductive tract. Through this important role, the placenta also determines postnatal health and susceptibility to disease. The hemochorial placenta is a prominent feature in primate and rodent development. This manuscript provides an overview of the basics of hemochorial placental development and function, provides perspectives on major discoveries that have shaped placental research, and thoughts on strategies for future investigation.

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Figures

Figure 1.
Figure 1.
Schematic representations of hemochorial placentation sites showing homologous structures within human, rat, and mouse. Note human and rat exhibit deep intrauterine trophoblast invasion, whereas trophoblast invasion in the mouse is shallow. (adapted from Ref. 241)
Figure 2.
Figure 2.
Timeline of selected technical advancements in placental research. In vitro and in vivo approaches that have positively impacted placental research over the past 50 years are presented.
Figure 3.
Figure 3.
Lentiviral-mediated trophectoderm gene delivery. (a) Procedure for lentiviral-mediated gene delivery. (b–d) Ubiquitin C promoter driven enhanced green fluorescent protein (EGFP) trophectoderm lentiviral delivery, transfer to pseudopregnant rats, and assessment at gestation day 13.5. Fetal–placental tissues were examined under bright field (b), fluorescence microscopy (c), or a merge of panels b and c (d). Note the placental-specific expression of EGFP. Scale bar = 2 mm (adapted from Ref. 163).
Figure 4.
Figure 4.
Placentation site plasticity: responses to hypoxia exposure during rat pregnancy. (a) Chicken beta actin promoter-enhanced green fluorescent protein (chβA-EGFP) transgenic model for monitoring intrauterine trophoblast cell invasion. (b) Gestation day 13.5 placentation site from a rat exposed to ambient oxygen. (c) Gestation day 13.5 placentation site from a rat exposed to hypoxia (∼11% oxygen) from gestation day 6.5–13.5. Maternal hypoxia activated endovascular trophoblast invasion. Scale bar = 0.5 mm (adapted from Ref. 235).
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References

    1. Gundling WE Jr, Wildman DE. A review of inter- and intraspecific variation in the eutherian placenta. Philos Trans R Soc Lond B Biol Sci 2015; 370:20140072. - PMC - PubMed
    1. Maltepe E, Fisher SJ. Placenta: the forgotten organ. Annu Rev Cell Dev Biol 2015; 31:523–552. - PubMed
    1. Soncin F, Natale D, Parast MM. Signaling pathways in mouse and human trophoblast differentiation: a comparative review. Cell Mol Life Sci 2015; 72:1291–1302. - PMC - PubMed
    1. Burton GJ, Fowden AL, Thornburg KL. Placental origins of chronic disease. Physiol Rev 2016; 96:1509–1565. - PMC - PubMed
    1. Roberts RM, Green JA, Schulz LC. The evolution of the placenta. Reproduction 2016; 152:R179–R189. - PMC - PubMed

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