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. 2019 Feb;33(3):328-334.
doi: 10.1080/14786419.2018.1448980. Epub 2018 Mar 12.

Triterpenoids and lignans from the stems of Schisandra glaucescens

Wenming Wu  1   2 , Hanli Ruan  1
Affiliations

Triterpenoids and lignans from the stems of Schisandra glaucescens

Wenming Wu et al. Nat Prod Res. 2019 Feb.

Abstract

Two new triterpenoids, 24( E)-3 α,12 α-dihydroxyl-lanost-9(11),24-dien-26-oid acid (1) and 3,4- seco-24( Z)-6 α,7 β-dihydroxyl-cycloart-4(28),24-dien-3,26-dioic-3-methyl ester (2), and ten known ones (3-12), together with eight lignans (13-20), were isolated from the stems of Schisandra glaucescens. Their structures were established on the basis of extensive spectroscopic analyses. Compounds 1-3, 5-7, 9, 11-13 and 15-18 were isolated from this species for the first time. 1 and 2 were evaluated for their in vitro cytotoxicities against the mouse cancer B16 cell line, human cancer HepG2 and MCF7 cell lines by MTT assay.

Keywords: cytotoxicity; lignans; triterpenoids.

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