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Review
. 2018 Oct;22(5):1046-1051.
doi: 10.1007/s10157-018-1556-4. Epub 2018 Mar 21.

Clinico-pathological features of kidney disease in diabetic cases

Kengo Furuichi  1 , Miho Shimizu  1 , Hirokazu Okada  2 , Ichiei Narita  3 , Takashi Wada  4
Affiliations
Review

Clinico-pathological features of kidney disease in diabetic cases

Kengo Furuichi et al. Clin Exp Nephrol. 2018 Oct.

Abstract

Diabetic kidney disease is the major cause of end-stage kidney disease in developed countries. However, the onset of kidney disorder and the progression pattern of kidney dysfunction and proteinuria greatly vary cases by cases. Therefore, risk classification with clinical data and pathological findings is important. Recent clinico-pathological study with kidney biopsy samples from diabetic patients revealed that pathological changes of diabetic nephropathy are characteristic and have special impacts on prognosis in each clinical stage. Moreover, comparison of the clinico-pathological findings of diabetic nephropathy with hypertensive nephrosclerosis revealed that there are few differences in their pathological findings in cases with low albuminuria and preserved estimated glomerular filtration rate (eGFR). Because it is so difficult to clearly distinguish pure kidney lesions caused by diabetes and kidney lesions due to effects other than diabetes, it is vital that these overlapped pathological findings be confirmed on kidney biopsy in cases of early stage diabetes. Further research is warranted regarding the pathogenesis of diabetic nephropathy and indication of kidney biopsy in diabetic cases.

Keywords: Diabetic kidney disease; Diabetic nephropathy; Nephrosclerosis.

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Conflict of interest statement

Conflict of interest

The author declares that there are no competing interests.

Human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Figures

Fig. 1
Fig. 1
Declining speed and rate of eGFR in diabetic nepropathy and nephrosclerosis. T test. #p < 0.05 to nephrosclerosis data from Ref. [16, 19]
Fig. 2
Fig. 2
Pathological score of diabetic nephropathy and nephrosclerosis. T test. #p < 0.05 to nephrosclerosis data from Ref. [16, 19]
Fig. 3
Fig. 3
A Venn diagram of the notions of diabetic kidney disease and diabetic nephropathy
Fig. 4
Fig. 4
Pathological findings of diabetic nephropathy and nephrosclerosis
See this image and copyright information in PMC

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