Association Between CHEK2*1100delC and Breast Cancer: A Systematic Review and Meta-Analysis

doi:10.1007/s40291-018-0344-x

Meta-Analysis

. 2018 Aug;22(4):397-407.

doi: 10.1007/s40291-018-0344-x.

Association Between CHEK2*1100delC and Breast Cancer: A Systematic Review and Meta-Analysis

Mingming Liang¹, Yun Zhang¹, Chenyu Sun², Feras Kamel Rizeq³, Min Min¹, Tingting Shi¹, Yehuan Sun^{4

5}

Affiliations

¹ Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
² The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei, 230022, China.
³ Avalon University School of Medicine, Santa Rosaweg 122 - 124, Willemstad, Curaçao.
⁴ Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. yhsun_ahmu_edu@yeah.net.
⁵ Center for Evidence-Based Practice, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. yhsun_ahmu_edu@yeah.net.

PMID: 29909568
DOI: 10.1007/s40291-018-0344-x

Meta-Analysis

Association Between CHEK2*1100delC and Breast Cancer: A Systematic Review and Meta-Analysis

Mingming Liang et al. Mol Diagn Ther. 2018 Aug.

. 2018 Aug;22(4):397-407.

doi: 10.1007/s40291-018-0344-x.

Authors

Mingming Liang¹, Yun Zhang¹, Chenyu Sun², Feras Kamel Rizeq³, Min Min¹, Tingting Shi¹, Yehuan Sun^{4

5}

Affiliations

¹ Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
² The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei, 230022, China.
³ Avalon University School of Medicine, Santa Rosaweg 122 - 124, Willemstad, Curaçao.
⁴ Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. yhsun_ahmu_edu@yeah.net.
⁵ Center for Evidence-Based Practice, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China. yhsun_ahmu_edu@yeah.net.

PMID: 29909568
DOI: 10.1007/s40291-018-0344-x

Abstract

Introduction: The association between the checkpoint kinase 2*1100delC (CHEK2*1100delC) and breast cancer has been extensively explored.

Objective: In light of the recent publication of studies on these specific findings, particularly regarding male patients with breast cancer, we performed an updated meta-analysis to investigate a more reliable estimate.

Methods: This meta-analysis included 26 published studies selected in a search of electronic databases up to January 2018, including 118,735 breast cancer cases and 195,807 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between 1100delC and breast cancer.

Results: Meta-analysis results suggested that 1100delC contributed to an increased breast cancer risk in overall populations (OR 2.89; 95% CI 2.63-3.16). Subgroup analysis found ORs of 3.13 (95% CI 1.94-5.07) for male breast cancer, 2.88 (95% CI 2.63-3.16) for female breast cancer, 2.87 (95% CI 1.85-4.47) for early-onset breast cancer, 2.92 (95% CI 2.65-3.22) for invasive breast cancer, and 3.21 (95% CI 2.41-4.29) for familial breast cancer. The sensitivity analysis suggested that results of this meta-analysis were generally robust.

Conclusion: CHEK2*1100delC is associated with an increased risk of both female and male breast cancer.

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References

1. J Clin Oncol. 2010 Apr 20;28(12):2114-22 - PubMed
1. Eur J Cancer. 2005 Aug;41(12):1819-23 - PubMed
1. N Engl J Med. 2016 Aug 4;375(5):443-53 - PubMed
1. J Clin Oncol. 2007 Jan 1;25(1):57-63 - PubMed
1. Int J Cancer. 2004 Jan 20;108(3):475-6 - PubMed

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[1] J Clin Oncol. 2010 Apr 20;28(12):2114-22 - PubMed

[2] J Clin Oncol. 2010 Apr 20;28(12):2114-22 - PubMed

[3] Eur J Cancer. 2005 Aug;41(12):1819-23 - PubMed

[4] Eur J Cancer. 2005 Aug;41(12):1819-23 - PubMed

[5] N Engl J Med. 2016 Aug 4;375(5):443-53 - PubMed

[6] N Engl J Med. 2016 Aug 4;375(5):443-53 - PubMed

[7] J Clin Oncol. 2007 Jan 1;25(1):57-63 - PubMed

[8] J Clin Oncol. 2007 Jan 1;25(1):57-63 - PubMed

[9] Int J Cancer. 2004 Jan 20;108(3):475-6 - PubMed

[10] Int J Cancer. 2004 Jan 20;108(3):475-6 - PubMed

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Association Between CHEK2*1100delC and Breast Cancer: A Systematic Review and Meta-Analysis

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Association Between CHEK2*1100delC and Breast Cancer: A Systematic Review and Meta-Analysis

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