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. 2018 Jun 21;8(1):9453.
doi: 10.1038/s41598-018-27896-y.

The dynamic change of neutrophil to lymphocyte ratio can predict clinical outcome in stage I-III colon cancer

Zhigui Li  1 , Rui Zhao  1 , Yaping Cui  1 , Yong Zhou  1 , Xiaoting Wu  2
Affiliations

The dynamic change of neutrophil to lymphocyte ratio can predict clinical outcome in stage I-III colon cancer

Zhigui Li et al. Sci Rep. .

Abstract

Whether the dynamic change of neutrophil to lymphocyte ratio (delta-NLR) can predict the outcome in various malignancies remained controversial. The delta-NLR has not been evaluated in colon cancer. Thus, we conducted the study to evaluate the predictive value of the delta-NLR in patients with colon cancer who underwent curative resection. Three-hundred and fifty-four patients with stage I-III colon cancer were retrospectively analysed. Clinicopathological features, preoperative NLR and postoperative NLR were collected. Prognostic factors were evaluated by univariate and multivariate analysis. The one, three and five-year overall survival rate in the delta-NLR < 0 group was 98.2%, 90.7% and 83.6%, respectively; and in the delta-NLR ≥ 0 group was 98.4%, 96.9% and 95.3%, respectively (log-rank test, P = 0.002). Univariate and multivariate analysis showed that there was a strong relationship between delta-NLR and overall survival. In conclusion, the delta-NLR was an independent prognostic factor for overall survival in early stage colon cancer. Patients with increased delta-NLR had an favourable clinical outcome.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Diagram showing the process of patients selection.
Figure 2
Figure 2
Receiver operating characteristic (ROC) curve analysis of the pre-NLR, post-NLR and delta-NLR.
Figure 3
Figure 3
Kaplan–Meier estimates of overall survival based on the pre-NLR.
Figure 4
Figure 4
Kaplan–Meier estimates of overall survival based on the post-NLR.
Figure 5
Figure 5
Kaplan–Meier estimates of overall survival based on the delta-NLR.
See this image and copyright information in PMC

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