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Review
. 2018 Jul;25(21):20569-20574.
doi: 10.1007/s11356-018-2426-z. Epub 2018 Jun 12.

Immune consequences induced by photodynamic therapy in non-melanoma skin cancers: a review

Xin Yu  1 , Heyi Zheng  2   3 , Matthew T V Chan  4 , William K K Wu  4   5
Affiliations
Review

Immune consequences induced by photodynamic therapy in non-melanoma skin cancers: a review

Xin Yu et al. Environ Sci Pollut Res Int. 2018 Jul.

Abstract

Photodynamic therapy (PDT) is widely used in dermatology to treat precancerous skin lesions and superficial non-melanoma skin cancers (NMSCs), including premalignant actinic keratosis, cutaneous squamous cell carcinoma in situ, and superficial basal cell carcinoma. The long-term cure rates of PDT range from 70 to 90% in NMSC patients, with excellent cosmetic results and good tolerance. However, the mechanism of action of PDT on tumors is complex. PDT not only kills tumor cells directly but also rapidly recruits immune cells to release inflammatory mediators to activate antitumor immunity. PDT-induced tumor death, also called immunogenic cell death, can trigger both innate and adaptive immune response, further enhancing the antitumor effect. For instance, inoculation of tumor cells killed via PDT to animals triggered a stronger antitumor immunity in vivo than tumor cell lysates produced by other treatments. More importantly, many immunotherapy regimens based on the immune effect of PDT have been developed and demonstrated to be a promising therapeutic method for cancer in pre-clinical trials. Therefore, increasing efforts have been undertaken to investigate the immune responses associated with PDT. In the present review, we first introduce the antitumor effect and the associated mechanisms of PDT in cancers. Then, we summarize studies on the immune responses induced by PDT in NMSCs. We also discuss the potential mechanisms underlying the process.

Keywords: Non-melanoma skin cancers; Photodynamic therapy; Tumor.

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References

    1. Adamek M, Kawczyk-Krupka A, Mostowy A, Czuba Z, Krol W, Kasperczyk S, Jakobisiak M, Golab J, Sieron A (2005) Topical ALA-PDT modifies neutrophils’ chemiluminescence, lymphocytes’ interleukin-1beta secretion and serum level of transforming growth factor beta1 in patients with nonmelanoma skin malignancies. A clinical study. Photodiagn Photodyn Ther 2:65–72 - DOI
    1. Agostinis P, Berg K, Cengel KA, Foster TH, Girotti AW, Gollnick SO, Hahn SM, Hamblin MR, Juzeniene A, Kessel D, Korbelik M, Moan J, Mroz P, Nowis D, Piette J, Wilson BC, Golab J (2011) Photodynamic therapy of cancer: an update. CA Cancer J Clin 61:250–281 - DOI
    1. Akimoto J (2016) Photodynamic therapy for malignant brain tumors. Neurol Med Chir 56:151–157 - DOI
    1. Babilas P, Landthaler M, Szeimies RM (2006) Photodynamic therapy in dermatology. Eur J Dermatol 16:340–348
    1. Bellnier DA, Gollnick SO, Camacho SH, Greco WR, Cheney RT (2003) Treatment with the tumor necrosis factor-alpha-inducing drug 5,6-dimethylxanthenone-4-acetic acid enhances the antitumor activity of the photodynamic therapy of RIF-1 mouse tumors. Cancer Res 63:7584–7590

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