Anti-MDA5 Antibody Spectrum in Western World

doi:10.1007/s11926-018-0798-1

Review

. 2018 Oct 31;20(12):78.

doi: 10.1007/s11926-018-0798-1.

Anti-MDA5 Antibody Spectrum in Western World

Siamak Moghadam-Kia^{1

2}, Chester V Oddis¹, Rohit Aggarwal³

Affiliations

¹ Myositis Center and Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
² VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.
³ Myositis Center and Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. aggarwalr@upmc.edu.

PMID: 30382445
DOI: 10.1007/s11926-018-0798-1

Review

Anti-MDA5 Antibody Spectrum in Western World

Siamak Moghadam-Kia et al. Curr Rheumatol Rep. 2018.

. 2018 Oct 31;20(12):78.

doi: 10.1007/s11926-018-0798-1.

Authors

Siamak Moghadam-Kia^{1

2}, Chester V Oddis¹, Rohit Aggarwal³

Affiliations

¹ Myositis Center and Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
² VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.
³ Myositis Center and Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. aggarwalr@upmc.edu.

PMID: 30382445
DOI: 10.1007/s11926-018-0798-1

Abstract

Purpose of review: Anti-melanoma differentiation-associated gene 5 (anti-MDA5) is a novel and highly specific myositis-associated autoantibody, which defines a unique phenotype among patients with dermatomyositis (DM).

Recent findings: Anti-MDA5 was originally characterized in Japan in DM patients with hallmark cutaneous features and no proximal muscle weakness and termed clinically amyopathic DM (CADM). Anti-MDA5 has characteristic cutaneous manifestations which include tender palmar papules and cutaneous ulcerations, along with an increased frequency of interstitial lung disease (ILD) that can be rapidly progressive (RPILD) and fatal. This review will highlight the clinical significance of anti-MDA5 autoantibodies in Caucasian DM patients.

Keywords: Anti-MDA5 autoantibody; Classic dermatomyositis (DM); Clinical features; Clinically amyopathic dermatomyositis (CADM).

PubMed Disclaimer

Cited by

IgM autoantibodies recognizing ACE2 are associated with severe COVID-19.
Casciola-Rosen L, Thiemann DR, Andrade F, Trejo Zambrano MI, Hooper JE, Leonard EK, Spangler JB, Cox AL, Machamer CE, Sauer L, Laeyendecker O, Garibaldi BT, Ray SC, Mecoli CA, Christopher-Stine L, Gutierrez-Alamillo L, Yang Q, Hines D, Clarke WA, Rothman R, Pekosz A, Fenstermacher KJ, Wang Z, Zeger SL, Rosen A. Casciola-Rosen L, et al. medRxiv [Preprint]. 2020 Oct 15:2020.10.13.20211664. doi: 10.1101/2020.10.13.20211664. medRxiv. 2020. Update in: JCI Insight. 2022 May 9;7(9):e158362. doi: 10.1172/jci.insight.158362 PMID: 33083808 Free PMC article. Updated. Preprint.
Understanding and managing anti-MDA 5 dermatomyositis, including potential COVID-19 mimicry.
Mehta P, Machado PM, Gupta L. Mehta P, et al. Rheumatol Int. 2021 Jun;41(6):1021-1036. doi: 10.1007/s00296-021-04819-1. Epub 2021 Mar 27. Rheumatol Int. 2021. PMID: 33774723 Free PMC article. Review.
Interstitial lung disease is not rare in immune-mediated necrotizing myopathy with anti-signal recognition particle antibodies.
Ge Y, Yang H, Xiao X, Liang L, Lu X, Wang G. Ge Y, et al. BMC Pulm Med. 2022 Jan 10;22(1):14. doi: 10.1186/s12890-021-01802-1. BMC Pulm Med. 2022. PMID: 35000598 Free PMC article.
Interstitial pneumonia with autoimmune features in a patient with melanoma differentiation-associated gene 5 (MDA5) antibody.
Hong LE, Proudman S, Limaye V. Hong LE, et al. BMJ Case Rep. 2020 Nov 30;13(11):e234946. doi: 10.1136/bcr-2020-234946. BMJ Case Rep. 2020. PMID: 33257351 Free PMC article.
Frequencies and clinical associations of myositis-related antibodies in The Netherlands: A one-year survey of all Dutch patients.
Platteel ACM, Wevers BA, Lim J, Bakker JA, Bontkes HJ, Curvers J, Damoiseaux J, Heron M, de Kort G, Limper M, van Lochem EG, Mulder AHL, Saris CGJ, van der Valk H, van der Kooi AJ, van Leeuwen EMM, Veltkamp M, Schreurs MWJ, Meek B, Hamann D. Platteel ACM, et al. J Transl Autoimmun. 2019 Aug 23;2:100013. doi: 10.1016/j.jtauto.2019.100013. eCollection 2019 Dec. J Transl Autoimmun. 2019. PMID: 32743501 Free PMC article.

See all "Cited by" articles

References

1. Rheumatology (Oxford). 2010 Sep;49(9):1713-9 - PubMed
1. J Am Acad Dermatol. 2006 Apr;54(4):597-613 - PubMed
1. Clin Rheumatol. 2016 Aug;35(8):2125-2130 - PubMed
1. J Rheumatol. 2005 Sep;32(9):1719-26 - PubMed
1. N Engl J Med. 1975 Feb 13;292(7):344-7 - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Springer
Medical
- MedlinePlus Health Information
Research Materials
- NCI CPTC Antibody Characterization Program

[1] Rheumatology (Oxford). 2010 Sep;49(9):1713-9 - PubMed

[2] Rheumatology (Oxford). 2010 Sep;49(9):1713-9 - PubMed

[3] J Am Acad Dermatol. 2006 Apr;54(4):597-613 - PubMed

[4] J Am Acad Dermatol. 2006 Apr;54(4):597-613 - PubMed

[5] Clin Rheumatol. 2016 Aug;35(8):2125-2130 - PubMed

[6] Clin Rheumatol. 2016 Aug;35(8):2125-2130 - PubMed

[7] J Rheumatol. 2005 Sep;32(9):1719-26 - PubMed

[8] J Rheumatol. 2005 Sep;32(9):1719-26 - PubMed

[9] N Engl J Med. 1975 Feb 13;292(7):344-7 - PubMed

[10] N Engl J Med. 1975 Feb 13;292(7):344-7 - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Anti-MDA5 Antibody Spectrum in Western World

Affiliations

Anti-MDA5 Antibody Spectrum in Western World

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Research Materials

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Medical

Research Materials