Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Mar;64(3):832-837.
doi: 10.1007/s10620-018-5387-7. Epub 2018 Nov 26.

Duodenal Pathology in Patients with Rumination Syndrome: Duodenal Eosinophilia and Increased Intraepithelial Lymphocytes

Magnus Halland  1 , Nicholas J Talley  2 , Mike Jones  3 , Joseph A Murray  4 , Raquel Cameron  2 , Marjorie M Walker  2
Affiliations

Duodenal Pathology in Patients with Rumination Syndrome: Duodenal Eosinophilia and Increased Intraepithelial Lymphocytes

Magnus Halland et al. Dig Dis Sci. 2019 Mar.

Abstract

Background: Rumination syndrome is a functional gastrointestinal disorder characterized by effortless, postprandial regurgitation. Duodenal eosinophilia has been described in patients with functional dyspepsia. Because of the significant symptomatic overlap between functional dyspepsia and rumination syndrome, we hypothesized that histological changes might exist among patients with rumination syndrome.

Methods: We included patients with rumination syndrome in whom we had obtained duodenal biopsies and compared these with controls. Digital images of biopsy specimens were analyzed for routine pathology and eosinophil counts by a pathologist blinded to the case-control status.

Results: The 22 patients with rumination syndrome had a mean age of 39.2 years (range 21-71) and 77% were female. The 10 controls had a mean age of 34.3 (range 27-69) and 80% were female. There was a significant increase in the mean eosinophil count among the patients with rumination syndrome compared to controls, 26 per mm2 (range 16-42) versus 18 per mm2 (range 10-28), p = 0.006. Intraepithelial lymphocyte counts were significantly higher in rumination patients (mean 15/100 enterocytes, range 8-29) versus controls (mean 11/100 enterocytes, range 11-18), p = 0.02.

Conclusion: Patients with rumination syndrome have subtle duodenal pathology with eosinophilia and increased intraepithelial lymphocyte counts compared to controls.

Keywords: Duodenal eosinophilia; Functional dyspepsia; Rumination syndrome.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Gastroenterology. 2006 Apr;130(5):1466-79 - PubMed
    1. Am J Gastroenterol. 2015 Aug;110(8):1205-15 - PubMed
    1. Gastroenterology. 2010 Jul;139(1):112-9 - PubMed
    1. Neurogastroenterol Motil. 2016 Mar;28(3):384-91 - PubMed
    1. J Neurogastroenterol Motil. 2013 Apr;19(2):259-60 - PubMed

Publication types

LinkOut - more resources

  NODES
Association 1
COMMUNITY 1
twitter 2