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Review
. 2018 Nov;42(7):425-431.
doi: 10.1053/j.semperi.2018.09.004. Epub 2018 Oct 2.

Genomics, microbiomics, proteomics, and metabolomics in bronchopulmonary dysplasia

Charitharth Vivek Lal  1 , Vineet Bhandari  2 , Namasivayam Ambalavanan  3
Affiliations
Review

Genomics, microbiomics, proteomics, and metabolomics in bronchopulmonary dysplasia

Charitharth Vivek Lal et al. Semin Perinatol. 2018 Nov.

Abstract

Bronchopulmonary Dysplasia (BPD) is a disorder with a multifactorial etiology and highly variable clinical phenotype. Several traditional biomarkers have been identified, but due to the complex disease phenotype, these biomarkers have low predictive accuracy for BPD. In recent years, newer technologies have facilitated the in-depth and unbiased analysis of 'big data' in delineating the diagnosis, pathogenesis, and mechanisms of diseases. Novel systems-biology based 'omic' approaches, including but not limited to genomics, microbiomics, proteomics, and metabolomics may help define the multiple cellular and humoral interactions that regulate normal as well as abnormal lung development and response to injury that are the hallmarks of BPD.

Keywords: BPD; Genetics; Metabolome; Microbiome; Proteome; Systems biology.

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Figures

Fig. 1 –
Fig. 1 –
Interaction of the various “omic” profiles inform about and contribute to the pathogenesis of the _target disease, bron-chopulmonary dysplasia or BPD.
See this image and copyright information in PMC

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