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Comparative Study
. 2020 Jan;26(1):551-557.
doi: 10.1007/s12253-018-00564-2. Epub 2018 Dec 11.

Sonic Hedgehog Protein is Frequently Up-Regulated in Pancreatic Cancer Compared to Colorectal Cancer

Madiha Niyaz  1 , Mosin S Khan  1 , Rauf A Wani  2 , Omar J Shah  3 , Syed Mudassar  4
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Free article
Comparative Study

Sonic Hedgehog Protein is Frequently Up-Regulated in Pancreatic Cancer Compared to Colorectal Cancer

Madiha Niyaz et al. Pathol Oncol Res. 2020 Jan.
Free article

Abstract

Sonic hedgehog (SHH) is a secreted protein which functions in autocrine or paracrine fashion on _target cells to activate hedgehog (HH) signalling cascade responsible for growth and proliferation. This study is an attempt to understand the expression dynamics of SHH protein in colon, rectal and pancreatic cancers. Protein expression of SHH was studied by Western Blotting in the histologically confirmed colon, rectum and pancreatic cancer tissue samples along with their adjacent normal tissues. Only 31.4% (11 of 35) and 26.9% (7 of 26) of colon and rectal cancer cases respectively showed an increase in SHH expression in tumours compared to 72.7% (24 of 33) of the pancreatic cancer cases when compared with their adjacent normal tissues. Our results suggest that SHH may have a strong role in the predisposition of Pancreatic cancer and could possibly be used as a diagnostic or prognostic biomarker.

Keywords: Colorectal cancer; Hedgehog signalling pathway; Pancreatic cancer; Protein expression; Sonic hedgehog; Western blotting.

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