Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications

doi:10.3390/dj6040072

Review

. 2018 Dec 13;6(4):72.

doi: 10.3390/dj6040072.

Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications

Gianrico Spagnuolo¹, Bruna Codispoti², Massimo Marrelli³, Carlo Rengo⁴, Sandro Rengo⁵, Marco Tatullo⁶

Affiliations

¹ Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", 80131 Naples, Italy. gspagnuo@unina.it.
² Unit of Experimental Medicine, Marrelli Health, 88900 Crotone, Italy. bruna.codispoti@tecnologicasrl.com.
³ Unit of Experimental Medicine, Marrelli Health, 88900 Crotone, Italy. prof.marrelli@libero.it.
⁴ Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", 80131 Naples, Italy. carlorengo@alice.it.
⁵ Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", 80131 Naples, Italy. sanrengo@unina.it.
⁶ Tecnologica Research Institute, Stem Cells Unit, 88900 Crotone, Italy. marco.tatullo@tecnologicasrl.com.

PMID: 30551556
PMCID: PMC6313393
DOI: 10.3390/dj6040072

Review

Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications

Gianrico Spagnuolo et al. Dent J (Basel). 2018.

. 2018 Dec 13;6(4):72.

doi: 10.3390/dj6040072.

Authors

Gianrico Spagnuolo¹, Bruna Codispoti², Massimo Marrelli³, Carlo Rengo⁴, Sandro Rengo⁵, Marco Tatullo⁶

Affiliations

¹ Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", 80131 Naples, Italy. gspagnuo@unina.it.
² Unit of Experimental Medicine, Marrelli Health, 88900 Crotone, Italy. bruna.codispoti@tecnologicasrl.com.
³ Unit of Experimental Medicine, Marrelli Health, 88900 Crotone, Italy. prof.marrelli@libero.it.
⁴ Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", 80131 Naples, Italy. carlorengo@alice.it.
⁵ Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", 80131 Naples, Italy. sanrengo@unina.it.
⁶ Tecnologica Research Institute, Stem Cells Unit, 88900 Crotone, Italy. marco.tatullo@tecnologicasrl.com.

PMID: 30551556
PMCID: PMC6313393
DOI: 10.3390/dj6040072

Abstract

Tissue engineering is based on the interaction between stem cells, biomaterials and factors delivered in biological niches. Oral tissues have been found to be rich in stem cells from different sources: Stem cells from oral cavity are easily harvestable and have shown a great plasticity towards the main lineages, specifically towards bone tissues. Dental pulp stem cells (DPSCs) are the most investigated mesenchymal stem cells (MSCs) from dental tissues, however, the oral cavity hosts several other stem cell lineages that have also been reported to be a good alternative in bone tissue engineering. In particular, the newly discovered population of mesenchymal stem cells derived from human periapical inflamed cysts (hPCy-MSCs) have showed very promising properties, including high plasticity toward bone, vascular and neural phenotypes. In this topical review, the authors described the main oral-derived stem cell populations, their most interesting characteristics and their ability towards osteogenic lineage. This review has also investigated the main clinical procedures, reported in the recent literature, involving oral derived-MSCs and biomaterials to get better bone regeneration in dental procedures. The numerous populations of mesenchymal stem cells isolated from oral tissues (DPSCs, SHEDs, PDLSCs, DFSCs, SCAPs, hPCy-MSCs) retain proliferation ability and multipotency; these features are exploited for clinical purposes, including regeneration of injured tissues and local immunomodulation; we reported on the last studies on the proper use of such MSCs within a biological niche and the proper way to storage them for future clinical use.

Keywords: bone tissue; oral-derived stem cells; regenerative medicine; tissue engineering.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

1. Munoz-Canoves P., Huch M. Definitions for adult stem cells debated. Nature. 2018;563:328–329. doi: 10.1038/d41586-018-07175-6. - DOI - PubMed
1. Tatullo M., Marrelli M., Paduano F. The regenerative medicine in oral and maxillofacial surgery: The most important innovations in the clinical application of mesenchymal stem cells. Int. J. Med. Sci. 2015;12:72–77. doi: 10.7150/ijms.10706. - DOI - PMC - PubMed
1. Pierdomenico L., Bonsi L., Calvitti M., Rondelli D., Arpinati M., Chirumbolo G., Becchetti E., Marchionni C., Alviano F., Fossati V., et al. Multipotent mesenchymal stem cells with immunosuppressive activity can be easily isolated from dental pulp. Transplantation. 2005;80:836–842. doi: 10.1097/01.tp.0000173794.72151.88. - DOI - PubMed
1. Yamaza T., Kentaro A., Chen C., Liu Y., Shi Y., Gronthos S., Wang S., Shi S. Immunomodulatory properties of stem cells from human exfoliated deciduous teeth. Stem Cell Res. Ther. 2010;1:5. doi: 10.1186/scrt5. - DOI - PMC - PubMed
1. Iohara K., Zheng L., Wake H., Ito M., Nabekura J., Wakita H., Nakamura H., Into T., Matsushita K., Nakashima M. A novel stem cell source for vasculogenesis in ischemia: Subfraction of side population cells from dental pulp. Stem Cells. 2008;26:2408–2418. doi: 10.1634/stemcells.2008-0393. - DOI - PubMed

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[1] Munoz-Canoves P., Huch M. Definitions for adult stem cells debated. Nature. 2018;563:328–329. doi: 10.1038/d41586-018-07175-6. - DOI - PubMed

[2] Munoz-Canoves P., Huch M. Definitions for adult stem cells debated. Nature. 2018;563:328–329. doi: 10.1038/d41586-018-07175-6. - DOI - PubMed

[3] Tatullo M., Marrelli M., Paduano F. The regenerative medicine in oral and maxillofacial surgery: The most important innovations in the clinical application of mesenchymal stem cells. Int. J. Med. Sci. 2015;12:72–77. doi: 10.7150/ijms.10706. - DOI - PMC - PubMed

[4] Tatullo M., Marrelli M., Paduano F. The regenerative medicine in oral and maxillofacial surgery: The most important innovations in the clinical application of mesenchymal stem cells. Int. J. Med. Sci. 2015;12:72–77. doi: 10.7150/ijms.10706. - DOI - PMC - PubMed

[5] Pierdomenico L., Bonsi L., Calvitti M., Rondelli D., Arpinati M., Chirumbolo G., Becchetti E., Marchionni C., Alviano F., Fossati V., et al. Multipotent mesenchymal stem cells with immunosuppressive activity can be easily isolated from dental pulp. Transplantation. 2005;80:836–842. doi: 10.1097/01.tp.0000173794.72151.88. - DOI - PubMed

[6] Pierdomenico L., Bonsi L., Calvitti M., Rondelli D., Arpinati M., Chirumbolo G., Becchetti E., Marchionni C., Alviano F., Fossati V., et al. Multipotent mesenchymal stem cells with immunosuppressive activity can be easily isolated from dental pulp. Transplantation. 2005;80:836–842. doi: 10.1097/01.tp.0000173794.72151.88. - DOI - PubMed

[7] Yamaza T., Kentaro A., Chen C., Liu Y., Shi Y., Gronthos S., Wang S., Shi S. Immunomodulatory properties of stem cells from human exfoliated deciduous teeth. Stem Cell Res. Ther. 2010;1:5. doi: 10.1186/scrt5. - DOI - PMC - PubMed

[8] Yamaza T., Kentaro A., Chen C., Liu Y., Shi Y., Gronthos S., Wang S., Shi S. Immunomodulatory properties of stem cells from human exfoliated deciduous teeth. Stem Cell Res. Ther. 2010;1:5. doi: 10.1186/scrt5. - DOI - PMC - PubMed

[9] Iohara K., Zheng L., Wake H., Ito M., Nabekura J., Wakita H., Nakamura H., Into T., Matsushita K., Nakashima M. A novel stem cell source for vasculogenesis in ischemia: Subfraction of side population cells from dental pulp. Stem Cells. 2008;26:2408–2418. doi: 10.1634/stemcells.2008-0393. - DOI - PubMed

[10] Iohara K., Zheng L., Wake H., Ito M., Nabekura J., Wakita H., Nakamura H., Into T., Matsushita K., Nakashima M. A novel stem cell source for vasculogenesis in ischemia: Subfraction of side population cells from dental pulp. Stem Cells. 2008;26:2408–2418. doi: 10.1634/stemcells.2008-0393. - DOI - PubMed

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Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications

Affiliations

Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications

Authors

Affiliations

Abstract

Conflict of interest statement

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