Reduced efficacy of low FODMAPs diet in patients with IBS-D carrying sucrase-isomaltase (SI) hypomorphic variants

doi:10.1136/gutjnl-2018-318036

Randomized Controlled Trial

. 2020 Feb;69(2):397-398.

doi: 10.1136/gutjnl-2018-318036. Epub 2019 Jan 18.

Reduced efficacy of low FODMAPs diet in patients with IBS-D carrying sucrase-isomaltase (SI) hypomorphic variants

Tenghao Zheng^{1

2}, Shanti Eswaran³, Amanda L Photenhauer³, Juanita L Merchant⁴, William D Chey^#³, Mauro D'Amato^#^{1

2

5

6}

Affiliations

¹ Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
² Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
³ Division of Gastroenterology, Michigan Medicine, Ann Arbor, Michigan, USA.
⁴ Division of Gastroenterology, University of Arizona, Tucson, Arizona, USA.
⁵ Departmentof Gastrointestinal and Liver Diseases, Biodonostia Health Research Institute, San Sebastián, Spain.
⁶ IKERBASQUE, Basque Science Foundation, Bilbao, Spain.

^# Contributed equally.

PMID: 30658996
PMCID: PMC6984052
DOI: 10.1136/gutjnl-2018-318036

Randomized Controlled Trial

Reduced efficacy of low FODMAPs diet in patients with IBS-D carrying sucrase-isomaltase (SI) hypomorphic variants

Tenghao Zheng et al. Gut. 2020 Feb.

. 2020 Feb;69(2):397-398.

doi: 10.1136/gutjnl-2018-318036. Epub 2019 Jan 18.

Authors

Tenghao Zheng^{1

2}, Shanti Eswaran³, Amanda L Photenhauer³, Juanita L Merchant⁴, William D Chey^#³, Mauro D'Amato^#^{1

2

5

6}

Affiliations

¹ Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
² Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
³ Division of Gastroenterology, Michigan Medicine, Ann Arbor, Michigan, USA.
⁴ Division of Gastroenterology, University of Arizona, Tucson, Arizona, USA.
⁵ Departmentof Gastrointestinal and Liver Diseases, Biodonostia Health Research Institute, San Sebastián, Spain.
⁶ IKERBASQUE, Basque Science Foundation, Bilbao, Spain.

^# Contributed equally.

PMID: 30658996
PMCID: PMC6984052
DOI: 10.1136/gutjnl-2018-318036

No abstract available

Keywords: carbohydrates; genetic polymorphisms; irritable bowel syndrome.

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Conflict of interest statement

Competing interests: The project has been partially supported by an unrestricted research grant from QOL Medical to MD’A.

Figures

**Figure 1**
Decreased symptom relief in patients with IBS and diarrhoea carrying sucrase-isomaltase (SI) hypomorphic variants. Adequate symptom relief in low fermentable oligo-, di-, mono-saccharides and polyols treated individuals, stratified according to SI genotype into carriers and non-carriers of hypomorphic variants. *P=0.031 (one-tailed logistic regression analysis, adjusting for age, sex, body mass index and ethnicity).

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References

1. Henström M, Diekmann L, Bonfiglio F, et al. . Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome. Gut 2018;67:263–70. 10.1136/gutjnl-2016-312456 - DOI - PMC - PubMed
1. Thingholm L, Rühlemann M, Wang J, et al. . Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition. Gut 2019;68:177–8. 10.1136/gutjnl-2017-315841 - DOI - PMC - PubMed
1. Garcia-Etxebarria K, Zheng T, Bonfiglio F, et al. . Increased prevalence of rare sucrase-isomaltase pathogenic variants in irritable bowel syndrome patients. Clin Gastroenterol Hepatol 2018;16:1673–6. 10.1016/j.cgh.2018.01.047 - DOI - PMC - PubMed
1. Gericke B, Amiri M, Naim HY. The multiple roles of sucrase-isomaltase in the intestinal physiology. Mol Cell Pediatr 2016;3:2 10.1186/s40348-016-0033-y - DOI - PMC - PubMed
1. De Giorgio R, Volta U, Gibson PR, et al. . gluten and FODMAPs in IBS: facts or fiction? Gut 2016;65:169–78. - PubMed

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[1] Henström M, Diekmann L, Bonfiglio F, et al. . Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome. Gut 2018;67:263–70. 10.1136/gutjnl-2016-312456 - DOI - PMC - PubMed

[2] Henström M, Diekmann L, Bonfiglio F, et al. . Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome. Gut 2018;67:263–70. 10.1136/gutjnl-2016-312456 - DOI - PMC - PubMed

[3] Thingholm L, Rühlemann M, Wang J, et al. . Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition. Gut 2019;68:177–8. 10.1136/gutjnl-2017-315841 - DOI - PMC - PubMed

[4] Thingholm L, Rühlemann M, Wang J, et al. . Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition. Gut 2019;68:177–8. 10.1136/gutjnl-2017-315841 - DOI - PMC - PubMed

[5] Garcia-Etxebarria K, Zheng T, Bonfiglio F, et al. . Increased prevalence of rare sucrase-isomaltase pathogenic variants in irritable bowel syndrome patients. Clin Gastroenterol Hepatol 2018;16:1673–6. 10.1016/j.cgh.2018.01.047 - DOI - PMC - PubMed

[6] Garcia-Etxebarria K, Zheng T, Bonfiglio F, et al. . Increased prevalence of rare sucrase-isomaltase pathogenic variants in irritable bowel syndrome patients. Clin Gastroenterol Hepatol 2018;16:1673–6. 10.1016/j.cgh.2018.01.047 - DOI - PMC - PubMed

[7] Gericke B, Amiri M, Naim HY. The multiple roles of sucrase-isomaltase in the intestinal physiology. Mol Cell Pediatr 2016;3:2 10.1186/s40348-016-0033-y - DOI - PMC - PubMed

[8] Gericke B, Amiri M, Naim HY. The multiple roles of sucrase-isomaltase in the intestinal physiology. Mol Cell Pediatr 2016;3:2 10.1186/s40348-016-0033-y - DOI - PMC - PubMed

[9] De Giorgio R, Volta U, Gibson PR, et al. . gluten and FODMAPs in IBS: facts or fiction? Gut 2016;65:169–78. - PubMed

[10] De Giorgio R, Volta U, Gibson PR, et al. . gluten and FODMAPs in IBS: facts or fiction? Gut 2016;65:169–78. - PubMed

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Reduced efficacy of low FODMAPs diet in patients with IBS-D carrying sucrase-isomaltase (SI) hypomorphic variants

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Reduced efficacy of low FODMAPs diet in patients with IBS-D carrying sucrase-isomaltase (SI) hypomorphic variants

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