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Review
. 2019 Oct 3:10:1222.
doi: 10.3389/fpls.2019.01222. eCollection 2019.

To Splice or to Transcribe: SKIP-Mediated Environmental Fitness and Development in Plants

Ying Cao  1 , Ligeng Ma  1
Affiliations
Review

To Splice or to Transcribe: SKIP-Mediated Environmental Fitness and Development in Plants

Ying Cao et al. Front Plant Sci. .

Abstract

Gene expression in eukaryotes is controlled at multiple levels, including transcriptional and post-transcriptional levels. The transcriptional regulation of gene expression is complex and includes the regulation of the initiation and elongation phases of transcription. Meanwhile, the post-transcriptional regulation of gene expression includes precursor messenger RNA (pre-mRNA) splicing, 5' capping, and 3' polyadenylation. Among these events, pre-mRNA splicing, conducted by the spliceosome, plays a key role in the regulation of gene expression, and the efficiency and precision of pre-mRNA splicing are critical for gene function. Ski-interacting protein (SKIP) is an evolutionarily conserved protein from yeast to humans. In plants, SKIP is a bifunctional regulator that works as a splicing factor as part of the spliceosome and as a transcriptional regulator via interactions with the transcriptional regulatory complex. Here, we review how the functions of SKIP as a splicing factor and a transcriptional regulator affect environmental fitness and development in plants.

Keywords: SKIP; alternative splicing; environmental fitness; plant development; splicing factor; transcriptional regulator.

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Figures

Figure 1
Figure 1
The domain structure of ski-interacting protein (SKIP) and the location of skip-1 mutant. Gray box: UTR; gray line: intron; black box: exon; colored boxes: domain feature of the protein; black line: the mutation site of the mutant.
Figure 2
Figure 2
The dual functions of SKIP in mediating environmental fitness and development in plants. SKIP is a splicing factor that regulates the alternative splicing of clock and stress tolerance-related genes in order to mediate the circadian clock and stress responses. It also functions as a transcriptional coactivator by interacting with RNA polymerase II-associated factor 1 complex (Paf1c) to activate FLC/MAFs transcription and mediate the floral transition.
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