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Review
. 2020 Mar;34(3):435-447.
doi: 10.1002/ptr.6538. Epub 2019 Nov 20.

Recent advances in the anti-aging effects of phytoestrogens on collagen, water content, and oxidative stress

Tao Liu  1   2   3 , Nan Li  1   2   3   4 , Yi-Qi Yan  1   2   3 , Yan Liu  5 , Ke Xiong  1   2   3 , Yang Liu  6 , Qing-Mei Xia  6 , Han Zhang  1   2   3 , Zhi-Dong Liu  1   2   3   4
Affiliations
Review

Recent advances in the anti-aging effects of phytoestrogens on collagen, water content, and oxidative stress

Tao Liu et al. Phytother Res. 2020 Mar.

Abstract

Skin undergoes degenerative changes as it ages, which include the loss of elasticity, reductions in the epidermal thickness and collagen content, elastic fiber degeneration, and increased wrinkling and dryness. Skin aging can be significantly delayed by the administration of estrogen. Estrogen deficiency following menopause results in atrophic skin changes and the acceleration of skin aging. Estrogen administration has positive effects on human skin by delaying or preventing skin aging manifestations, but the use of estrogen replacement is a risk factor for breast and uterine cancer. Phytoestrogens are a large family of plant-derived molecules possessing various degrees of estrogen-like activity; they exhibit agonist or antagonist estrogenic properties depending on the tissue. These molecules could be ideal candidates to combat skin aging and other detrimental effects of hypoestrogenism. In this paper, we review the effects of phytoestrogens on human skin and the mechanisms by which phytoestrogens can alleviate the changes due to aging.

Keywords: collagen; estrogen; oxidative stress; phytoestrogens; skin aging; water content.

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Molecular structure of phytoestrogens
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