The extended renin-angiotensin system: a promising _target for traumatic brain injury therapeutics

doi:10.4103/1673-5374.270304

Review

. 2020 Jun;15(6):1025-1026.

doi: 10.4103/1673-5374.270304.

The extended renin-angiotensin system: a promising _target for traumatic brain injury therapeutics

Zachary C Janatpour¹, Aviva J Symes¹

Affiliations

PMID: 31823875
PMCID: PMC7034274
DOI: 10.4103/1673-5374.270304

Review

The extended renin-angiotensin system: a promising _target for traumatic brain injury therapeutics

Zachary C Janatpour et al. Neural Regen Res. 2020 Jun.

. 2020 Jun;15(6):1025-1026.

doi: 10.4103/1673-5374.270304.

Authors

Zachary C Janatpour¹, Aviva J Symes¹

Affiliation

¹ Department of Pharmacology, Uniformed Services University, Bethesda, MD, USA.

PMID: 31823875
PMCID: PMC7034274
DOI: 10.4103/1673-5374.270304

No abstract available

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Conflict of interest statement

None

Figures

**Figure 1**
Effects of RAS-modulating ligands on TBI. Various ligands that act on receptors of the RAS and/or eRAS reduce sequelae of TBI in rodent models. Downward green arrows depict a ligand’s documented ability to reduce a particular sequela of TBI in rodents. Question marks depict unknown associations between a ligand and a particular sequela of TBI in rodents. eRAS: Extended renin-angiotensin system; RAS: renin-angiotensin system; TBI: traumatic brain injury.

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References

1. GBD 2016 Dementia Collaborators. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18:88–106. - PMC - PubMed
1. Jackson L, Eldahshan W, Fagan SC, Ergul A. Int J Mol Sci. 2018. Within the brain: The renin angiotensin system. doi: 10.3390/ijms19030876. - PMC - PubMed
1. Janatpour ZC, Korotcov A, Bosomtwi A, Dardzinski BJ, Symes AJ. Subcutaneous administration of angiotensin-(1-7) improves recovery after traumatic brain injury in mice. J Neurotrauma. 2019 doi: 101089/neu20196376. - PubMed
1. Joseph JP, Mecca AP, Regenhardt RW, Bennion DM, Rodríguez V, Desland F, Patel NA, Pioquinto DJ, Unger T, Katovich MJ, Steckelings UM, Sumners C. The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke. Neuropharmacology. 2014;81:134–141. - PMC - PubMed
1. McCarthy CA, Vinh A, Callaway JK, Widdop RE. Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke. Stroke. 2009;40:1482–1489. - PubMed

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[1] GBD 2016 Dementia Collaborators. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18:88–106. - PMC - PubMed

[2] GBD 2016 Dementia Collaborators. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18:88–106. - PMC - PubMed

[3] Jackson L, Eldahshan W, Fagan SC, Ergul A. Int J Mol Sci. 2018. Within the brain: The renin angiotensin system. doi: 10.3390/ijms19030876. - PMC - PubMed

[4] Jackson L, Eldahshan W, Fagan SC, Ergul A. Int J Mol Sci. 2018. Within the brain: The renin angiotensin system. doi: 10.3390/ijms19030876. - PMC - PubMed

[5] Janatpour ZC, Korotcov A, Bosomtwi A, Dardzinski BJ, Symes AJ. Subcutaneous administration of angiotensin-(1-7) improves recovery after traumatic brain injury in mice. J Neurotrauma. 2019 doi: 101089/neu20196376. - PubMed

[6] Janatpour ZC, Korotcov A, Bosomtwi A, Dardzinski BJ, Symes AJ. Subcutaneous administration of angiotensin-(1-7) improves recovery after traumatic brain injury in mice. J Neurotrauma. 2019 doi: 101089/neu20196376. - PubMed

[7] Joseph JP, Mecca AP, Regenhardt RW, Bennion DM, Rodríguez V, Desland F, Patel NA, Pioquinto DJ, Unger T, Katovich MJ, Steckelings UM, Sumners C. The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke. Neuropharmacology. 2014;81:134–141. - PMC - PubMed

[8] Joseph JP, Mecca AP, Regenhardt RW, Bennion DM, Rodríguez V, Desland F, Patel NA, Pioquinto DJ, Unger T, Katovich MJ, Steckelings UM, Sumners C. The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke. Neuropharmacology. 2014;81:134–141. - PMC - PubMed

[9] McCarthy CA, Vinh A, Callaway JK, Widdop RE. Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke. Stroke. 2009;40:1482–1489. - PubMed

[10] McCarthy CA, Vinh A, Callaway JK, Widdop RE. Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke. Stroke. 2009;40:1482–1489. - PubMed

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The extended renin-angiotensin system: a promising _target for traumatic brain injury therapeutics

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The extended renin-angiotensin system: a promising _target for traumatic brain injury therapeutics

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