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. 2019 Oct 11;12(3):181-185.
doi: 10.4103/ojo.OJO_39_2018. eCollection 2019 Sep-Dec.

Long term effect of panretinal photocoagulation on retinal nerve fiber layer parameters in patients with proliferative diabetic retinopathy

Meenakshi Wadhwani  1 , Shweta Bali  2 , Shibal Bhartiya  3 , Manish Mahabir  4 , Ashish Upadhaya  5 , Tanuj Dada  6 , Anu Sharma  7 , Sanjay Kumar Mishra  8
Affiliations

Long term effect of panretinal photocoagulation on retinal nerve fiber layer parameters in patients with proliferative diabetic retinopathy

Meenakshi Wadhwani et al. Oman J Ophthalmol. .

Abstract

Purpose: This study aimed to evaluate the long-term effect of panretinal photocoagulation (PRP) on the retinal nerve fiber layer (RNFL) in patients with proliferative diabetic retinopathy (PDR).

Methods: This was a prospective longitudinal cohort study examining 42 eyes of 42 patients with PDR undergoing PRP. Peripapillary RNFL thickness (RNFLT) was measured using spectral-domain optical coherence tomography at baseline, 1 year, and 3 years following PRP.

Results: The mean "average RNFLT" was 89.88 ± 14.26 μm at baseline, 85.75 ± 11.36 μm at 1-year follow-up, and 83.33 ± 11.96 μm at 3-year follow-up. There was a statistically significant difference in the average RNFL thickness at baseline and 1 year and 3 years after PRP. At 1-year follow-up, superior, inferior, and nasal RNFL measurements reduced significantly from baseline (P < 0.01). The reduction in RNFL remained statistically significant for superior and inferior quadrants 3 years after PRP.

Conclusion: PRP causes a reduction in RNFL thickness until 3 years after the procedure. Caution should be exercised while interpreting peripapillary RNFL thickness scans in patients who have undergone PRP for diabetic retinopathy.

Keywords: Optical coherence tomogram; panretinal photocoagulation; proliferative diabetic retinopathy.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Change in retinal nerve fiber layer thickness following panretinal photocoagulation
See this image and copyright information in PMC

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