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. 2020 Jan 14;11(7):1648-1656.
doi: 10.7150/jca.39319. eCollection 2020.

Loss of SUSD2 expression correlates with poor prognosis in patients with surgically resected lung adenocarcinoma

Wei Guo  1 , Fei Shao  2   1 , Sijin Sun  1 , Peng Song  1 , Lei Guo  3 , Xuemin Xue  3 , Guochao Zhang  1 , Hao Zhang  1 , Yibo Gao  1 , Bin Qiu  1 , Fengwei Tan  1 , Shugeng Gao  1 , Jie He  1
Affiliations

Loss of SUSD2 expression correlates with poor prognosis in patients with surgically resected lung adenocarcinoma

Wei Guo et al. J Cancer. .

Abstract

There is limited evidence regarding the relationship between the expression of Sushi Domain Containing 2 (SUSD2) and prognosis of patients with surgically resected lung adenocarcinoma (LUAD). This retrospective study aimed to investigate the clinical significance of SUSD2 expression in LUAD. To assess SUSD2 expression in LUAD, we conducted both integrated bioinformatic analysis based on the TCGA database and also immunohistochemistry study using a tissue microarray encompassing 578 LUAD cases from our hospital. Reduced SUSD2 expression was associated with gender, smoking history, higher pathological grade, lymph node metastasis, larger tumor length, advanced TNM stage. LUAD patients with SUSD2-positive tumors showed significantly better overall survival (OS) than those with SUSD2-negative tumors (P = 0.000). When patients were stratified into those with stage I (218, 37.7%), II (152, 26.3%) and III (208, 36.0%) disease, and those without (254, 43.9%) and with (324, 56.1%) lymph node metastasis, the prognostic effect was almost consistent. The OS of patients with positive SUSD2 expression was significantly better in patients with stage I (P = 0.000), III (P = 0.000), without (P = 0.000) and with (P = 0.001) lymph node metastasis. Multivariate analysis showed that loss of SUSD2 predicted a shorter survival time and was an independent prognostic factor for LUAD patients. Our study indicated that SUSD2 may serve as a new prognostic and potential therapeutic _target in LUAD.

Keywords: Biomarker; Immunohistochemistry; Lung adenocarcinoma; Prognosis; Sushi Domain Containing 2.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
The flowchart of the enrollment process
Figure 2
Figure 2
Representative photomicrographs of lung adenocarcinoma (LUAD) TMA sections. Figure 2A-2B show representative photomicrographs stained with SUSD2 which score = 0. Figure 2C-2D show representative photomicrographs stained with SUSD2 which score = 1. Figure 2E-2F show representative photomicrographs stained with SUSD2 which score = 2. Figure 2G-2H show representative photomicrographs stained with SUSD2 which score = 3.
Figure 3
Figure 3
Expression of SUSD2 in different types of human cancers (A) Expression of SUSD2 in different types of human cancers in Oncomine database; (B) Expression of SUSD2 in different types of human cancers by GEPIA analysis (Dot plot); (C) Expression of SUSD2 in different types of human cancers by GEPIA analysis (Bar plot).
Figure 4
Figure 4
SUSD2 expression analysis and survival analysis of LUAD patients in TCGA database
Figure 5
Figure 5
Kaplan-Meier curves showing survival of the 578 patients with LUAD according to SUSD2 expression.
Figure 6
Figure 6
Kaplan-Meier curves showing survival of the 673 patients with LUAD in KM-PLOT database according to SUSD2 expression.
See this image and copyright information in PMC

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References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. - PubMed
    1. Chansky K, Sculier J-P, Crowley JJ, Giroux D, Van Meerbeeck J, Goldstraw P, International Staging Committee, Participating Institutions. The International Association for the Study of Lung Cancer Staging Project: prognostic factors and pathologic TNM stage in surgically managed non-small cell lung cancer. J Thorac Oncol. 2009;4(7):792–801. - PubMed
    1. Meza R, Meernik C, Jeon J, Cote ML. Lung cancer incidence trends by gender, race and histology in the United States, 1973-2010. PLoS One. 2015;10(3):e0121323. - PMC - PubMed
    1. Didkowska J, Wojciechowska U, Mańczuk M, Łobaszewski J. Lung cancer epidemiology: contemporary and future challenges worldwide. Ann Transl Med; 2016. p. 4. (8) - PMC - PubMed
    1. Watson AP, Evans RL, Egland KA. Multiple functions of sushi domain containing 2 (SUSD2) in breast tumorigenesis. Mol Cancer Res. 2013;11(1):74–85. - PMC - PubMed
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