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Case Reports
. 2020 Jul;158(1):e9-e13.
doi: 10.1016/j.chest.2020.03.039. Epub 2020 Mar 31.

Treatment With Convalescent Plasma for Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Bin Zhang  1 , Shuyi Liu  1 , Tan Tan  2 , Wenhui Huang  1 , Yuhao Dong  3 , Luyan Chen  1 , Qiuying Chen  1 , Lu Zhang  1 , Qingyang Zhong  4 , Xiaoping Zhang  5 , Yujian Zou  6 , Shuixing Zhang  7
Affiliations
Case Reports

Treatment With Convalescent Plasma for Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Bin Zhang et al. Chest. 2020 Jul.

Abstract

As of March 24, 2020, novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for 379,661 infection cases with 16,428 deaths globally, and the number is still increasing rapidly. Herein, we present four critically ill patients with SARS-CoV-2 infection who received supportive care and convalescent plasma. Although all four patients (including a pregnant woman) recovered from SARS-CoV-2 infection eventually, randomized trials are needed to eliminate the effect of other treatments and investigate the safety and efficacy of convalescent plasma therapy.

Keywords: SARS-CoV-2; convalescent plasma; critical illness.

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Figure 1
Figure 1
Timeline of symptom onset, reverse transcriptase polymerase chain reaction testing, antiviral therapies, severe complications, convalescent plasma transfusion, levels of virus load and antibodies after transfusion, and outcomes of the four critically ill patients with severe acute respiratory syndrome coronavirus 2 infection. CRRT = continuous renal replacement therapy; F = female; M = male; PCR = polymerase chain reaction; V-V ECMO = veno-venous extracorporeal membrane oxygenation.
See this image and copyright information in PMC

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References

    1. Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China [published online ahead of print February 28, 2020]. N Engl J Med. https://doi.org/10.1056/NEJMoa2002032. - DOI - PMC - PubMed
    1. Chen N., Zhou M., Dong X. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507–513. - PMC - PubMed
    1. Cao B, Wang Y, Wen D, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 [published online ahead of print March 18, 2020]. N Engl J Med. https://doi.org/10.1056/NEJMe2005477. - DOI - PMC - PubMed
    1. Chen L, Xiong J, Bao L, et al. Convalescent plasma as a potential therapy for COVID-19 [published online ahead of print February 27, 2020]. Lancet Infect Dis. https://doi.org/10.1016/S1473-3099(20)30141-9. - DOI - PMC - PubMed
    1. Soo Y.O., Cheng Y., Wong R. Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients. Clin Microbiol Infect. 2004;10(7):676–678. - PMC - PubMed

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