Sensor based on redox conjugated poly(para-phenylene) for the simultaneous detection of dopamine, ascorbic acid, and uric acid in human serum sample
- PMID: 32415513
- DOI: 10.1007/s00216-020-02686-6
Sensor based on redox conjugated poly(para-phenylene) for the simultaneous detection of dopamine, ascorbic acid, and uric acid in human serum sample
Abstract
An electrochemical sensor for the individual and the simultaneous detection of dopamine (DA), ascorbic acid (AA), and uric acid (UA) based on redox conjugated "poly(para-phenylene)" (Fc-ac-PPP) bearing ferrocene and carboxylic acid in lateral position has been developed. The electrochemical characterization of the sensor has been studied with cyclic voltammetry (CV), differential pulse voltammetry (DPV), and chronoamperometry (CA). We highlighted that the catalytic activity of the Fc-ac-PPP polymer provided by its redox electrochemical properties and chemical structure allows the electrochemical detection of DA, AA, and UA. We demonstrated that the sensor provides high sensitivity and selective signal in the coexistence of DA, AA, and UA within a short time. Low detection limits and wide linear ranges of detection have been demonstrated respectively for DA 3 × 10-10 M (1 nM-10 μM), AA 1.6 × 10-8 M (0.1 μM-1 mM), and UA 1 × 10-8 M (0.1 μM-1 mM). In addition, the sensor has been successfully applied to determine DA in urine and human serum samples even in the presence of high concentrations of AA and UA. This sensor could be a powerful device for the detection of other electroactive compounds thanks to its high catalytic properties and chemical structure. Graphical abstract.
Keywords: Ascorbic acid; Dopamine; Electrochemical detection; Ferrocene; Poly(para-phenylene); Uric acid.
Similar articles
-
Nanocomposite based on Poly (para-phenylene)/Chemical Reduced Graphene Oxide as a Platform for Simultaneous Detection of Ascorbic Acid, Dopamine and Uric Acid.Sensors (Basel). 2020 Feb 25;20(5):1256. doi: 10.3390/s20051256. Sensors (Basel). 2020. PMID: 32106578 Free PMC article.
-
Lithium cobalt phosphate electrode for the simultaneous determination of ascorbic acid, dopamine, and serum uric acid by differential pulse voltammetry.Mikrochim Acta. 2021 May 15;188(6):190. doi: 10.1007/s00604-021-04839-5. Mikrochim Acta. 2021. PMID: 33991256
-
Simultaneous determination of catecholamines, uric acid and ascorbic acid at physiological levels using poly(N-methylpyrrole)/Pd-nanoclusters sensor.Anal Biochem. 2010 May 1;400(1):78-88. doi: 10.1016/j.ab.2010.01.001. Epub 2010 Jan 11. Anal Biochem. 2010. PMID: 20064483
-
Recent Advances in Electrochemical and Optical Sensing of Dopamine.Sensors (Basel). 2020 Feb 14;20(4):1039. doi: 10.3390/s20041039. Sensors (Basel). 2020. PMID: 32075167 Free PMC article. Review.
-
The Renaissance of Ferrocene-Based Electrocatalysts: Properties, Synthesis Strategies, and Applications.Top Curr Chem (Cham). 2023 Nov 1;381(6):32. doi: 10.1007/s41061-023-00441-w. Top Curr Chem (Cham). 2023. PMID: 37910233 Review.
Cited by
-
Development of conducting paper-based electrochemical biosensor for procalcitonin detection.ADMET DMPK. 2023 Jan 30;11(2):263-275. doi: 10.5599/admet.1575. eCollection 2023. ADMET DMPK. 2023. PMID: 37325120 Free PMC article.
-
Hemin-doped metal-organic frameworks based nanozyme electrochemical sensor with high stability and sensitivity for dopamine detection.RSC Adv. 2021 Jan 11;11(4):2446-2452. doi: 10.1039/d0ra08224d. eCollection 2021 Jan 6. RSC Adv. 2021. PMID: 35424163 Free PMC article.
-
Recent Advances in Layered Double Hydroxide-Based Electrochemical and Optical Sensors.Nanomaterials (Basel). 2021 Oct 22;11(11):2809. doi: 10.3390/nano11112809. Nanomaterials (Basel). 2021. PMID: 34835574 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
