An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

doi:10.12688/f1000research.22092.1

Review

. 2020 Jun 29:9:F1000 Faculty Rev-653.

doi: 10.12688/f1000research.22092.1. eCollection 2020.

An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

Jiahuai Han¹, Jianfeng Wu¹, John Silke^{2

3}

Affiliations

¹ State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361005, China.
² The Walter and Eliza Hall Institute, IG Royal Parade, Parkville, Victoria, 3052, Australia.
³ Department of Medical Biology, University of Melbourne, Parkville, Victoria, 3050, Australia.

PMID: 32612808
PMCID: PMC7324945
DOI: 10.12688/f1000research.22092.1

Review

An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

Jiahuai Han et al. F1000Res. 2020.

. 2020 Jun 29:9:F1000 Faculty Rev-653.

doi: 10.12688/f1000research.22092.1. eCollection 2020.

Authors

Jiahuai Han¹, Jianfeng Wu¹, John Silke^{2

3}

Affiliations

¹ State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361005, China.
² The Walter and Eliza Hall Institute, IG Royal Parade, Parkville, Victoria, 3052, Australia.
³ Department of Medical Biology, University of Melbourne, Parkville, Victoria, 3050, Australia.

PMID: 32612808
PMCID: PMC7324945
DOI: 10.12688/f1000research.22092.1

Abstract

The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli. This review provides a succinct summary of multiple aspects of the biology, role, and substrates of the mammalian family of p38 kinases. Since p38 activity is implicated in inflammatory and other diseases, we also discuss the clinical implications and pharmaceutical approaches to inhibit p38.

Keywords: MAPK; inflammation; p38; signalling.

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Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

Figures

**Figure 1.. A diagram of the p38 pathway.**
MKP, mitogen-activated protein kinase phosphatase; TAB1, TAK1-binding protein 1; Tyr, tyrosine.

See this image and copyright information in PMC

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References

1. Han J, Lee JD, Tobias PS, et al. : Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14. J Biol Chem. 1993;268(33):25009–25014. - PubMed
1. Han J, Lee JD, Bibbs L, et al. : A MAP kinase _targeted by endotoxin and hyperosmolarity in mammalian cells. Science. 1994;265(5173):808–811. 10.1126/science.7914033 - DOI - PubMed
1. Rouse J, Cohen P, Trigon S, et al. : A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell. 1994;78(6):1027–1037. 10.1016/0092-8674(94)90277-1 - DOI - PubMed
1. Freshney NW, Rawlinson L, Guesdon F, et al. : Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell. 1994;78(6):1039–1049. 10.1016/0092-8674(94)90278-x - DOI - PubMed
1. Lee JC, Laydon JT, McDonnell PC, et al. : A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature. 1994;372(6508):739–746. 10.1038/372739a0 - DOI - PubMed

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Grants and funding

This work was supported by the National Natural Science Foundation of China (81788101, 31420103910 and 81630042 to J.H.), the 111 Project (B12001 to J.H.) and by an NHMRC fellowship (1107149) to JS.

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[1] Han J, Lee JD, Tobias PS, et al. : Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14. J Biol Chem. 1993;268(33):25009–25014. - PubMed

[2] Han J, Lee JD, Tobias PS, et al. : Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14. J Biol Chem. 1993;268(33):25009–25014. - PubMed

[3] Han J, Lee JD, Bibbs L, et al. : A MAP kinase _targeted by endotoxin and hyperosmolarity in mammalian cells. Science. 1994;265(5173):808–811. 10.1126/science.7914033 - DOI - PubMed

[4] Han J, Lee JD, Bibbs L, et al. : A MAP kinase _targeted by endotoxin and hyperosmolarity in mammalian cells. Science. 1994;265(5173):808–811. 10.1126/science.7914033 - DOI - PubMed

[5] Rouse J, Cohen P, Trigon S, et al. : A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell. 1994;78(6):1027–1037. 10.1016/0092-8674(94)90277-1 - DOI - PubMed

[6] Rouse J, Cohen P, Trigon S, et al. : A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell. 1994;78(6):1027–1037. 10.1016/0092-8674(94)90277-1 - DOI - PubMed

[7] Freshney NW, Rawlinson L, Guesdon F, et al. : Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell. 1994;78(6):1039–1049. 10.1016/0092-8674(94)90278-x - DOI - PubMed

[8] Freshney NW, Rawlinson L, Guesdon F, et al. : Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell. 1994;78(6):1039–1049. 10.1016/0092-8674(94)90278-x - DOI - PubMed

[9] Lee JC, Laydon JT, McDonnell PC, et al. : A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature. 1994;372(6508):739–746. 10.1038/372739a0 - DOI - PubMed

[10] Lee JC, Laydon JT, McDonnell PC, et al. : A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature. 1994;372(6508):739–746. 10.1038/372739a0 - DOI - PubMed

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An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

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An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

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