Effects of high-intensity interval training compared with resistance training in prostate cancer patients undergoing radiotherapy: a randomized controlled trial

doi:10.1038/s41391-020-0259-6

Randomized Controlled Trial

. 2021 Mar;24(1):156-165.

doi: 10.1038/s41391-020-0259-6. Epub 2020 Jul 27.

Effects of high-intensity interval training compared with resistance training in prostate cancer patients undergoing radiotherapy: a randomized controlled trial

Elise Piraux^{1

2

3}, Gilles Caty^#^{4

5

6}, Laurette Renard⁷, David Vancraeynest^{8

9}, Bertrand Tombal¹⁰, Xavier Geets^{7

11}, Gregory Reychler^#^{12

13

14

15}

Affiliations

¹ Pôle de Neuro Musculo Skeletal Lab, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium. elise.piraux@uclouvain.be.
² Pôle de Pneumologie, ORL & Dermatologie, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium. elise.piraux@uclouvain.be.
³ Clinical Neuroscience, Institute of Neurosciences, Université catholique de Louvain, Brussels, Belgium. elise.piraux@uclouvain.be.
⁴ Pôle de Neuro Musculo Skeletal Lab, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.
⁵ Clinical Neuroscience, Institute of Neurosciences, Université catholique de Louvain, Brussels, Belgium.
⁶ Service de médecine physique et réadaptation, Cliniques universitaires Saint-Luc, Brussels, Belgium.
⁷ Department of Radiation Oncology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
⁸ Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.
⁹ Division of Cardiology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
¹⁰ Service d'urologie, Cliniques universitaires Saint-Luc, Brussels, Belgium.
¹¹ Molecular Imaging, Radiotherapy and Oncology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.
¹² Pôle de Pneumologie, ORL & Dermatologie, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.
¹³ Haute Ecole Léonard de Vinci, PARNASSE-ISEI, Brussels, Belgium.
¹⁴ Secteur de kinésithérapie, Cliniques universitaires Saint-Luc, Brussels, Belgium.
¹⁵ Service de Pneumologie, Cliniques universitaires Saint-Luc, Brussels, Belgium.

^# Contributed equally.

PMID: 32719354
DOI: 10.1038/s41391-020-0259-6

Randomized Controlled Trial

Effects of high-intensity interval training compared with resistance training in prostate cancer patients undergoing radiotherapy: a randomized controlled trial

Elise Piraux et al. Prostate Cancer Prostatic Dis. 2021 Mar.

. 2021 Mar;24(1):156-165.

doi: 10.1038/s41391-020-0259-6. Epub 2020 Jul 27.

Authors

Elise Piraux^{1

2

3}, Gilles Caty^#^{4

5

6}, Laurette Renard⁷, David Vancraeynest^{8

9}, Bertrand Tombal¹⁰, Xavier Geets^{7

11}, Gregory Reychler^#^{12

13

14

15}

Affiliations

¹ Pôle de Neuro Musculo Skeletal Lab, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium. elise.piraux@uclouvain.be.
² Pôle de Pneumologie, ORL & Dermatologie, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium. elise.piraux@uclouvain.be.
³ Clinical Neuroscience, Institute of Neurosciences, Université catholique de Louvain, Brussels, Belgium. elise.piraux@uclouvain.be.
⁴ Pôle de Neuro Musculo Skeletal Lab, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.
⁵ Clinical Neuroscience, Institute of Neurosciences, Université catholique de Louvain, Brussels, Belgium.
⁶ Service de médecine physique et réadaptation, Cliniques universitaires Saint-Luc, Brussels, Belgium.
⁷ Department of Radiation Oncology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
⁸ Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.
⁹ Division of Cardiology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
¹⁰ Service d'urologie, Cliniques universitaires Saint-Luc, Brussels, Belgium.
¹¹ Molecular Imaging, Radiotherapy and Oncology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.
¹² Pôle de Pneumologie, ORL & Dermatologie, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.
¹³ Haute Ecole Léonard de Vinci, PARNASSE-ISEI, Brussels, Belgium.
¹⁴ Secteur de kinésithérapie, Cliniques universitaires Saint-Luc, Brussels, Belgium.
¹⁵ Service de Pneumologie, Cliniques universitaires Saint-Luc, Brussels, Belgium.

^# Contributed equally.

PMID: 32719354
DOI: 10.1038/s41391-020-0259-6

Abstract

Background: Exercise training has shown beneficial effects in the management of radiotherapy-related side effects in prostate cancer (PCa) patients undergoing radiation therapy (RT). However, the optimal modality of the exercise programs have not been yet determined. The aim of this randomized controlled trial was to investigate the effects of high-intensity interval training (HIIT) and resistance training (RES) compared to usual care (UC) on cancer-treatment-related fatigue (CTRF) (primary outcome), quality of life, depression, daytime sleepiness, insomnia, sleep quality, functional exercise capacity and executive function in PCa patients during RT.

Methods: PCa patients undergoing RT with or without ADT were randomized in HIIT, RES or UC. Both exercise programs included three sessions per week during 5-8 weeks. HIIT consisted of 8-15 × 60 s intervals (≥85% maximal heart rate). RES was performed with 1-3 sets of 8-12 repetitions for each large muscle groups. The primary outcome was changed in CTRF measured with the Functional Assessment of Chronic Illness Therapy-Fatigue.

Results: Seventy-two subjects (69.1 ± 8.2 years) completed the study. No exercise-related adverse events occurred. HIIT (p = 0.012) and RES (p = 0.039) training attenuated increases in CTRF compared to UC. Functional exercise capacity, evaluated by the 6-min walk test, increased after HIIT (p = 0 = 0.43) and RES (p = 0.041) compared to UC (+0.1%). No other secondary variables were different between groups.

Conclusions: Both intervention groups displayed beneficial effects on CTRF and functional exercise capacity in PCa patients undergoing RT. In addition, HIIT and RES are both safe with an excellent attendance rate to the exercise sessions.

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References

1. Parker C, Gillessen S, Heidenreich A, Horwich A. Cancer of the prostate: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26:v69–77. - PubMed
1. Bacon CG, Giovannucci E, Testa M, Kawachi I. The impact of cancer treatment on quality of life outcomes for patients with localized prostate cancer. J Urol. 2001;166:1804–10. - PubMed
1. Potosky AL, Legler J, Albertsen PC, Stanford JL, Gilliland FD, Hamilton AS, et al. Health outcomes after prostatectomy or radiotherapy for prostate cancer: results from the Prostate Cancer Outcomes Study. J Natl Cancer Inst. 2000;92:1582–92. - PubMed
1. Miaskowski C, Paul SM, Cooper BA, Lee K, Dodd M, West C, et al. Trajectories of fatigue in men with prostate cancer before, during, and after radiation therapy. J Pain Symptom Manag. 2008;35:632–43.
1. Truong PT, Berthelet E, Lee JC, Petersen R, Lim JT, Gaul CA, et al. Prospective evaluation of the prevalence and severity of fatigue in patients with prostate cancer undergoing radical external beam radiotherapy and neoadjuvant hormone therapy. Can J Urol. 2006;13:3139–46. - PubMed

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[1] Parker C, Gillessen S, Heidenreich A, Horwich A. Cancer of the prostate: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26:v69–77. - PubMed

[2] Parker C, Gillessen S, Heidenreich A, Horwich A. Cancer of the prostate: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26:v69–77. - PubMed

[3] Bacon CG, Giovannucci E, Testa M, Kawachi I. The impact of cancer treatment on quality of life outcomes for patients with localized prostate cancer. J Urol. 2001;166:1804–10. - PubMed

[4] Bacon CG, Giovannucci E, Testa M, Kawachi I. The impact of cancer treatment on quality of life outcomes for patients with localized prostate cancer. J Urol. 2001;166:1804–10. - PubMed

[5] Potosky AL, Legler J, Albertsen PC, Stanford JL, Gilliland FD, Hamilton AS, et al. Health outcomes after prostatectomy or radiotherapy for prostate cancer: results from the Prostate Cancer Outcomes Study. J Natl Cancer Inst. 2000;92:1582–92. - PubMed

[6] Potosky AL, Legler J, Albertsen PC, Stanford JL, Gilliland FD, Hamilton AS, et al. Health outcomes after prostatectomy or radiotherapy for prostate cancer: results from the Prostate Cancer Outcomes Study. J Natl Cancer Inst. 2000;92:1582–92. - PubMed

[7] Miaskowski C, Paul SM, Cooper BA, Lee K, Dodd M, West C, et al. Trajectories of fatigue in men with prostate cancer before, during, and after radiation therapy. J Pain Symptom Manag. 2008;35:632–43.

[8] Miaskowski C, Paul SM, Cooper BA, Lee K, Dodd M, West C, et al. Trajectories of fatigue in men with prostate cancer before, during, and after radiation therapy. J Pain Symptom Manag. 2008;35:632–43.

[9] Truong PT, Berthelet E, Lee JC, Petersen R, Lim JT, Gaul CA, et al. Prospective evaluation of the prevalence and severity of fatigue in patients with prostate cancer undergoing radical external beam radiotherapy and neoadjuvant hormone therapy. Can J Urol. 2006;13:3139–46. - PubMed

[10] Truong PT, Berthelet E, Lee JC, Petersen R, Lim JT, Gaul CA, et al. Prospective evaluation of the prevalence and severity of fatigue in patients with prostate cancer undergoing radical external beam radiotherapy and neoadjuvant hormone therapy. Can J Urol. 2006;13:3139–46. - PubMed

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Effects of high-intensity interval training compared with resistance training in prostate cancer patients undergoing radiotherapy: a randomized controlled trial

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Effects of high-intensity interval training compared with resistance training in prostate cancer patients undergoing radiotherapy: a randomized controlled trial

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