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Review
. 2020 Jul 8:11:1016.
doi: 10.3389/fphar.2020.01016. eCollection 2020.

Advance in Drug Delivery for Ageing Skeletal Muscle

Yi Li  1   2 , Ming Chen  1   2 , Yanpeng Zhao  1   2 , Ming Li  1   2 , Yong Qin  3 , Shi Cheng  3 , Yanyu Yang  4 , Pengbin Yin  1   2 , Licheng Zhang  1   2 , Peifu Tang  1   2
Affiliations
Review

Advance in Drug Delivery for Ageing Skeletal Muscle

Yi Li et al. Front Pharmacol. .

Abstract

The age-related loss of skeletal muscle, sarcopenia, is characterized by progressive loss of muscle mass, reduction in muscle strength, and dysfunction of physical performance. It has become a global health problem leading to several adverse outcomes in the ageing population. Research on skeletal muscle loss prevention and treatment is developing quickly. However, the current clinical approaches to sarcopenia are limited. Recently, novel drug delivery systems offer new possibilities for treating aged muscle loss. Herein, we briefly recapitulate the potential therapeutic _targets of aged skeletal muscle and provide a concise advance in the drug delivery systems, mainly focus on the use of nano-carriers. Furthermore, we elaborately discuss the prospect of aged skeletal muscle treatment by nanotechnology approaches.

Keywords: ageing skeletal muscle; drug delivery; extracellular vesicle; sarcopenia; skeletal muscle regeneration.

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Figures

Figure 1
Figure 1
Schematic representation of the four consecutive phases during skeletal muscle regeneration.
Figure 2
Figure 2
Timeline of inflammatory responses and immune cell during muscle regeneration.
Figure 3
Figure 3
Bone-secreted factors regulate interorgan crosstalk. Reproduced, with permission, from (Li Y. et al., 2019).
Figure 4
Figure 4
Structure of extracellular vesicles. Reproduced, with permission, from (Rong et al., 2020).
See this image and copyright information in PMC

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