Guidelines for COVID-19 Management in Hematopoietic Cell Transplantation and Cellular Therapy Recipients

doi:10.1016/j.bbmt.2020.07.027

Practice Guideline

. 2020 Nov;26(11):1983-1994.

doi: 10.1016/j.bbmt.2020.07.027. Epub 2020 Jul 28.

Guidelines for COVID-19 Management in Hematopoietic Cell Transplantation and Cellular Therapy Recipients

Affiliations

¹ University of Washington, Seattle Children's Hospital, Fred Hutchinson Cancer Research Center, Seattle, Washington. Electronic address: awaghmar@fredhutch.org.
² University of Colorado Denver, Denver, Colorado.
³ University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington.
⁴ University of Texas MD Anderson Cancer Center, Houston, Texas.
⁵ City of Hope National Medical Center, Duarte, California.
⁶ The Ohio State University Medical Center/The James Cancer Center and Solove Research Institute, Columbus, Ohio.
⁷ Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
⁸ University of Washington, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, Seattle, Washington.
⁹ Levine Cancer Institute/Atrium Health, Charlotte, North Carolina.

PMID: 32736007
PMCID: PMC7386267
DOI: 10.1016/j.bbmt.2020.07.027

Practice Guideline

Guidelines for COVID-19 Management in Hematopoietic Cell Transplantation and Cellular Therapy Recipients

Alpana Waghmare et al. Biol Blood Marrow Transplant. 2020 Nov.

. 2020 Nov;26(11):1983-1994.

doi: 10.1016/j.bbmt.2020.07.027. Epub 2020 Jul 28.

Authors

Affiliations

¹ University of Washington, Seattle Children's Hospital, Fred Hutchinson Cancer Research Center, Seattle, Washington. Electronic address: awaghmar@fredhutch.org.
² University of Colorado Denver, Denver, Colorado.
³ University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington.
⁴ University of Texas MD Anderson Cancer Center, Houston, Texas.
⁵ City of Hope National Medical Center, Duarte, California.
⁶ The Ohio State University Medical Center/The James Cancer Center and Solove Research Institute, Columbus, Ohio.
⁷ Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York.
⁸ University of Washington, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, Seattle, Washington.
⁹ Levine Cancer Institute/Atrium Health, Charlotte, North Carolina.

PMID: 32736007
PMCID: PMC7386267
DOI: 10.1016/j.bbmt.2020.07.027

Abstract

There are currently limited data on the epidemiology, clinical manifestations, and optimal management of Coronavirus Disease 2019 (COVID-19) in hematopoietic cell transplantation and cellular therapy recipients. Given the experience with other respiratory viruses, we anticipate that patients may develop severe clinical disease and thus provide the following general principles for cancer centers across the nation. These guidelines were developed by members of the American Society for Transplantation and Cellular Therapy Infectious Diseases Special Interest Group. Specific practices may vary depending on local epidemiology and testing capacity, and the guidance provided in this document may change as new information becomes available.

Keywords: COVID-19; SARS-CoV-2; cellular therapy; hematopoietic cell transplan.

PubMed Disclaimer

Figures

**Figure 1**
Evaluation of HCT and cellular therapy candidates.

**Figure 2**
Suggested infection prevention practices for bone marrow transplant units.

See this image and copyright information in PMC

Cited by

Successful Autologous Bone Marrow Transplantation in Active COVID-19 Patients: Case Report.
Amer R, Sabateen A, El-Hamshary Y, Salameh H, Hroub B, Sawalhi H, Sawalmeh O. Amer R, et al. Transplant Proc. 2023 Apr;55(3):543-546. doi: 10.1016/j.transproceed.2023.02.032. Epub 2023 Feb 27. Transplant Proc. 2023. PMID: 36967338 Free PMC article.
Nosocomial COVID-19 at a comprehensive cancer center during the first year of the pandemic: Lessons learned.
Khawaja F, Srinivasan K, Spallone A, Feldman A, Cantu S, Ariza-Heredia E, Dvordak T, Alousi A, Ahmed S, George M, Frenzel E, Bhatti M, Chemaly RF. Khawaja F, et al. Am J Infect Control. 2023 May;51(5):506-513. doi: 10.1016/j.ajic.2022.07.019. Epub 2022 Jul 25. Am J Infect Control. 2023. PMID: 35901993 Free PMC article.
Pulmonary Complications in Hematopoietic Stem Cell Transplant Recipients-A Clinician Primer.
Astashchanka A, Ryan J, Lin E, Nokes B, Jamieson C, Kligerman S, Malhotra A, Mandel J, Joshua J. Astashchanka A, et al. J Clin Med. 2021 Jul 22;10(15):3227. doi: 10.3390/jcm10153227. J Clin Med. 2021. PMID: 34362012 Free PMC article. Review.
Treatment of Acute Leukemia During COVID-19: Focused Review of Evidence.
Singh S, Singh J, Paul D, Jain K. Singh S, et al. Clin Lymphoma Myeloma Leuk. 2021 May;21(5):289-294. doi: 10.1016/j.clml.2021.01.004. Epub 2021 Jan 12. Clin Lymphoma Myeloma Leuk. 2021. PMID: 33558204 Free PMC article. Review.
Update on the management of multiple sclerosis during the COVID-19 pandemic and post pandemic: An international consensus statement.
Reyes S, Cunningham AL, Kalincik T, Havrdová EK, Isobe N, Pakpoor J, Airas L, Bunyan RF, van der Walt A, Oh J, Mathews J, Mateen FJ, Giovannoni G. Reyes S, et al. J Neuroimmunol. 2021 Aug 15;357:577627. doi: 10.1016/j.jneuroim.2021.577627. Epub 2021 Jun 7. J Neuroimmunol. 2021. PMID: 34139567 Free PMC article. Review.

See all "Cited by" articles

References

1. Ljungman P, Mikulska M, de la Camara R, et al. The challenge of COVID-19 and hematopoietic cell transplantation; EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy [e-pub ahead of print]. Bone Marrow Transplant. doi: 10.1038/s41409-020-0919-0. - PMC - PubMed
1. Bachanova V, Bishop MR, Dahi P, et al. Chimeric antigen receptor T cell therapy during the COVID-19 pandemic. Biol Blood Marrow Transplant. 2020;26:1239–1246. - PMC - PubMed
1. Centers for Disease Control and Prevention. Overview of testing for SARS-CoV-2. Available at: https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-criteria.html. Accessed July 20,2020.
1. Yang Y, Yang M, Shen C, et al. Evaluating the accuracy of different respiratory specimens in the laboratory diagnosis and monitoring the viral shedding of 2019-nCoV infections. medRxiv. 2020 doi: 10.1101/2020.02.11.20021493. - DOI
1. Boonyaratanakornkit J, Vivek M, Xie H, et al. Predictive value of respiratory viral detection in the upper respiratory tract for infection of the lower respiratory tract with hematopoietic stem cell transplantation. J Infect Dis. 2020;221:379–388. - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information
Miscellaneous
- NCI CPTAC Assay Portal

[1] Ljungman P, Mikulska M, de la Camara R, et al. The challenge of COVID-19 and hematopoietic cell transplantation; EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy [e-pub ahead of print]. Bone Marrow Transplant. doi: 10.1038/s41409-020-0919-0. - PMC - PubMed

[2] Ljungman P, Mikulska M, de la Camara R, et al. The challenge of COVID-19 and hematopoietic cell transplantation; EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy [e-pub ahead of print]. Bone Marrow Transplant. doi: 10.1038/s41409-020-0919-0. - PMC - PubMed

[3] Bachanova V, Bishop MR, Dahi P, et al. Chimeric antigen receptor T cell therapy during the COVID-19 pandemic. Biol Blood Marrow Transplant. 2020;26:1239–1246. - PMC - PubMed

[4] Bachanova V, Bishop MR, Dahi P, et al. Chimeric antigen receptor T cell therapy during the COVID-19 pandemic. Biol Blood Marrow Transplant. 2020;26:1239–1246. - PMC - PubMed

[5] Centers for Disease Control and Prevention. Overview of testing for SARS-CoV-2. Available at: https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-criteria.html. Accessed July 20,2020.

[6] Centers for Disease Control and Prevention. Overview of testing for SARS-CoV-2. Available at: https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-criteria.html. Accessed July 20,2020.

[7] Yang Y, Yang M, Shen C, et al. Evaluating the accuracy of different respiratory specimens in the laboratory diagnosis and monitoring the viral shedding of 2019-nCoV infections. medRxiv. 2020 doi: 10.1101/2020.02.11.20021493. - DOI

[8] Yang Y, Yang M, Shen C, et al. Evaluating the accuracy of different respiratory specimens in the laboratory diagnosis and monitoring the viral shedding of 2019-nCoV infections. medRxiv. 2020 doi: 10.1101/2020.02.11.20021493. - DOI

[9] Boonyaratanakornkit J, Vivek M, Xie H, et al. Predictive value of respiratory viral detection in the upper respiratory tract for infection of the lower respiratory tract with hematopoietic stem cell transplantation. J Infect Dis. 2020;221:379–388. - PMC - PubMed

[10] Boonyaratanakornkit J, Vivek M, Xie H, et al. Predictive value of respiratory viral detection in the upper respiratory tract for infection of the lower respiratory tract with hematopoietic stem cell transplantation. J Infect Dis. 2020;221:379–388. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Guidelines for COVID-19 Management in Hematopoietic Cell Transplantation and Cellular Therapy Recipients

Affiliations

Guidelines for COVID-19 Management in Hematopoietic Cell Transplantation and Cellular Therapy Recipients

Authors

Affiliations

Abstract

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous