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. 2016 Jan 25;53(1):29-33.
doi: 10.2141/jpsa.0150087.

Peripheral Injection of Chicken Growth Hormone-Releasing Hormone Inhibits Feeding Behavior in Chicks

Tetsuya Tachibana  1 , Sachiyo Kubo  1 , Md Sakirul Islam Khan  2 , Keiko Masuda  3 , Kazuyoshi Ukena  3 , Yajun Wang  4
Affiliations

Peripheral Injection of Chicken Growth Hormone-Releasing Hormone Inhibits Feeding Behavior in Chicks

Tetsuya Tachibana et al. J Poult Sci. .

Abstract

Growth hormone-releasing hormone (GHRH), a stimulator of growth hormone (GH) secretion, is known to have several physiological roles such as the regulation of feeding behavior in mammals. Recently, we have reported that central injection of chicken GHRH decreased food intake in chicks, however, its peripheral role on feeding behavior has not been clarified. The purpose of the present study was to investigate the effect of peripheral injection of GHRH on feeding behavior in chicks (Gallus gallus). Intraperitoneal (IP) injection of GHRH47 (1 nmol), full length form of chicken GHRH significantly decreased food intake in chicks although the injection of GHRH27 and GHRH27-NH2, short forms of chicken GHRH had no effect. The IP injection of GHRH47 did not induced any abnormal behavior, suggesting that GHRH47-induced anorexia might not be related to abnormal behavior such as sleeping, hyperactivity and convulsion. The anorexigenic effect of GHRH47 seemed not to be related to GH because IP injection of bovine GH did not affect feeding behavior in chicks. Collectively, these results suggest that peripheral GHRH is related to inhibit feeding behavior in chicks.

Keywords: behavior; chick; feeding; growth hormone; growth hormone-releasing hormone; intraperitoneal injection.

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Figures

Fig. 1.
Fig. 1.
Food intake after IP injection of GHRH27, GHRH27-NH2 and GHRH47 in chicks under an ad libitum feeding condition. Data are expressed as means±SEM. The number of chicks was 8 in each group of GHRH27 study and 9 in each group of GHRH27-NH2 and GHRH47 studies. Groups with different letters are significantly different at each time (P<0.05).
Fig. 2.
Fig. 2.
Food intake after IP injection of GHRH-LP in chicks under an ad libitum feeding condition. Data are expressed as means±SEM. The number of chicks in 0, 0.2 and 1.0 nmol groups was 8, 8 and 7, respectively.
Fig. 3.
Fig. 3.
Effect of IP injection of bovine GH on food intake in chicks under an ad libitum feeding condition. Data are expressed as means±SEM. The number of chicks was 9 in each group.
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References

    1. Buntin JD, Figge GR. Prolactin and growth hormone stimulate food intake in ring doves. Pharmacology Biochemistry and Behavior, 31: 533-540. 1988. - PubMed
    1. Christodoulou C, Schally AV, Chatzistamou I, Kondi-Pafiti A, Lamnissou K, Kouloheri S, Kalofoutis A, Kiaris H. Expression of growth hormone-releasing hormone (GHRH) and splice variant of GHRH receptors in normal mouse tissues. Regulatory Peptides, 136: 105-108. 2006. - PubMed
    1. Harvey S, Gineste C, Gaylinn BD. Growth hormone (GH)-releasing activity of chicken GH-releasing hormone (GHRH) in chickens. General and Comparative Endocrinology, 204: 261-266. 2014. - PubMed
    1. Huang G, He X, Jiang X, Li J, Du H, Wang Y. cGHRH1-27NH2 is a ligand for the growth hormone-releasing hormone receptors (GHRHR1 and GHRHR2) in chickens. Journal of Sichuan University (Natural Science Edition), 49: 677-680. 2012.
    1. Imaki T, Shibasaki T, Hotta M, Masuda A, Demura H, Shizume K, Ling N. The satiety effect of growth hormone-releasing factor in rats. Brain Research, 340: 186-188. 1985. - PubMed

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