Analysis of galectin-3 levels as a source of coronary heart disease risk during periodontitis

doi:10.1111/jre.12860

. 2021 Jun;56(3):597-605.

doi: 10.1111/jre.12860. Epub 2021 Feb 28.

Analysis of galectin-3 levels as a source of coronary heart disease risk during periodontitis

Gaetano Isola¹, Alessandro Polizzi¹, Angela Alibrandi², Ray C Williams³, Antonino Lo Giudice¹

Affiliations

¹ Department of General Surgery and Surgical-Medical Specialties, Unit of Periodontology, School of Dentistry, University of Catania, Catania, Italy.
² Department of Economics, Unit of Statistical and Mathematical Sciences, University of Messina, Messina, Italy.
³ Department of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.

PMID: 33641161
DOI: 10.1111/jre.12860

Analysis of galectin-3 levels as a source of coronary heart disease risk during periodontitis

Gaetano Isola et al. J Periodontal Res. 2021 Jun.

. 2021 Jun;56(3):597-605.

doi: 10.1111/jre.12860. Epub 2021 Feb 28.

Authors

Gaetano Isola¹, Alessandro Polizzi¹, Angela Alibrandi², Ray C Williams³, Antonino Lo Giudice¹

Affiliations

¹ Department of General Surgery and Surgical-Medical Specialties, Unit of Periodontology, School of Dentistry, University of Catania, Catania, Italy.
² Department of Economics, Unit of Statistical and Mathematical Sciences, University of Messina, Messina, Italy.
³ Department of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.

PMID: 33641161
DOI: 10.1111/jre.12860

Abstract

Background and objective: Different evidence has shown that Galectins have a key role as modulators of cell surface functions and signaling in a wide range of inflammatory diseases during their preclinical stages. The aim of this study was to analyze the association and impact of periodontitis and coronary heart disease (CHD) on salivary and serum Galectin-3 in patients with periodontitis and CHD.

Materials and methods: For the present study, healthy controls (n = 38), periodontitis (n = 40), CHD (n = 39), and a combination of periodontitis +CHD (n = 38) patients were enrolled and analyzed. In each patient, demographic characteristics and a full-mouth clinical periodontal examination were achieved. Moreover, serum and salivary samples were collected to assess Galectin-3 and Endothelin-1 (ET-1) levels. The Jonckheere-Terpstra p-trend and Spearman's correlation tests as well as uni- and linear regression analyses were used to analyze the study data.

Results: Patients with periodontitis (serum, p = .003; saliva, p < .001) and periodontitis + CHD groups (serum p = .004; saliva, p < .001) had higher median serum and salivary concentrations of Galectin-3 in comparison with CHD and healthy controls. Serum (p = .006) and salivary (p = .009) Galectin-3 levels were significantly correlated with serum ET-1. The multivariate regression analysis highlighted that periodontitis (p = .047) was the significant predictor of serum Galectin-3 levels while ET-1 (p = .028) was the significant predictor of salivary Galectin-3 levels.

Conclusion: The results showed that patients with periodontitis and periodontitis + CHD presented significant higher serum and salivary Galectin-3 levels in comparison with CHD patients and healthy subjects. Periodontitis and ET-1 were the significant predictors of serum and salivary Galectin-3 levels, respectively.

Keywords: c-reactive protein; clinical trial; coronary heart disease; endothelin-1; galectin-3; periodontitis.

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References

REFERENCES

1. Kassebaum NJ, Bernabe E, Dahiya M, Bhandari B, Murray CJ, Marcenes W. Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res. 2014;93(11):1045-1053.
1. Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Periodontol. 2018;89(Suppl 1):S159-S172.
1. Isola G, Polizzi A, Alibrandi A, Williams RC, Leonardi R. Independent impact of periodontitis and cardiovascular disease on elevated soluble urokinase-type plasminogen activator receptor (suPAR) levels. Journal of Periodontology. 2020. http://dx.doi.org/10.1002/jper.20-0242
1. Aoyama N, Kobayashi N, Hanatani T, et al. Periodontal condition in Japanese coronary heart disease patients: A comparison between coronary and non-coronary heart diseases. J Periodontal Res. 2019;54(3):259-265.
1. Isola G, Lo Giudice A, Polizzi A, Alibrandi A, Murabito P, Indelicato F. Identification of the different salivary Interleukin-6 profiles in patients with periodontitis: a cross-sectional study. Arch Oral Biol. 2021;122:104997.

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[1] Kassebaum NJ, Bernabe E, Dahiya M, Bhandari B, Murray CJ, Marcenes W. Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res. 2014;93(11):1045-1053.

[2] Kassebaum NJ, Bernabe E, Dahiya M, Bhandari B, Murray CJ, Marcenes W. Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res. 2014;93(11):1045-1053.

[3] Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Periodontol. 2018;89(Suppl 1):S159-S172.

[4] Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Periodontol. 2018;89(Suppl 1):S159-S172.

[5] Isola G, Polizzi A, Alibrandi A, Williams RC, Leonardi R. Independent impact of periodontitis and cardiovascular disease on elevated soluble urokinase-type plasminogen activator receptor (suPAR) levels. Journal of Periodontology. 2020. http://dx.doi.org/10.1002/jper.20-0242

[6] Isola G, Polizzi A, Alibrandi A, Williams RC, Leonardi R. Independent impact of periodontitis and cardiovascular disease on elevated soluble urokinase-type plasminogen activator receptor (suPAR) levels. Journal of Periodontology. 2020. http://dx.doi.org/10.1002/jper.20-0242

[7] Aoyama N, Kobayashi N, Hanatani T, et al. Periodontal condition in Japanese coronary heart disease patients: A comparison between coronary and non-coronary heart diseases. J Periodontal Res. 2019;54(3):259-265.

[8] Aoyama N, Kobayashi N, Hanatani T, et al. Periodontal condition in Japanese coronary heart disease patients: A comparison between coronary and non-coronary heart diseases. J Periodontal Res. 2019;54(3):259-265.

[9] Isola G, Lo Giudice A, Polizzi A, Alibrandi A, Murabito P, Indelicato F. Identification of the different salivary Interleukin-6 profiles in patients with periodontitis: a cross-sectional study. Arch Oral Biol. 2021;122:104997.

[10] Isola G, Lo Giudice A, Polizzi A, Alibrandi A, Murabito P, Indelicato F. Identification of the different salivary Interleukin-6 profiles in patients with periodontitis: a cross-sectional study. Arch Oral Biol. 2021;122:104997.

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Analysis of galectin-3 levels as a source of coronary heart disease risk during periodontitis

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Analysis of galectin-3 levels as a source of coronary heart disease risk during periodontitis

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Abstract

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