The Impact of Sclerostin Levels on Long-Term Prognosis in Patients Undergoing Coronary Angiography: A Personalized Approach with 9-Year Follow-Up

doi:10.3390/jpm11030186

. 2021 Mar 6;11(3):186.

doi: 10.3390/jpm11030186.

The Impact of Sclerostin Levels on Long-Term Prognosis in Patients Undergoing Coronary Angiography: A Personalized Approach with 9-Year Follow-Up

Adam Kern^{1

2}, Tomasz Stompór³, Jolanta Kiewisz⁴, Bartłomiej E Kraziński⁴, Jacek Kiezun⁴, Marta Kiezun⁵, Jerzy Górny², Ewa Sienkiewicz², Leszek Gromadziński¹, Dariusz Onichimowski^{6

7}, Jacek Bil⁸

Affiliations

¹ Department of Cardiology and Internal Medicine, Medical Faculty, University of Warmia and Mazury in Olsztyn, 10-561 Olsztyn, Poland.
² Department of Cardiology, Voivodal Specialist Hospital in Olsztyn, 10-561 Olsztyn, Poland.
³ Department of Nephrology, Hypertension and Internal Medicine, Medical Faculty, University of Warmia and Mazury in Olsztyn, 10-561 Olsztyn, Poland.
⁴ Department of Human Histology and Embryology, Medical Faculty, University of Warmia and Mazury in Olsztyn, 10-561 Olsztyn, Poland.
⁵ Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-561 Olsztyn, Poland.
⁶ Department of Anaesthesiology and Intensive Care, School of Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, 10-561 Olsztyn, Poland.
⁷ Clinical Department of Anaesthesiology and Intensive Care, Voivodal Specialist Hospital in Olsztyn, 10-561 Olsztyn, Poland.
⁸ Department of Invasive Cardiology, Centre of Postgraduate Medical Education, 02-507 Warsaw, Poland.

PMID: 33800939
PMCID: PMC8001826
DOI: 10.3390/jpm11030186

The Impact of Sclerostin Levels on Long-Term Prognosis in Patients Undergoing Coronary Angiography: A Personalized Approach with 9-Year Follow-Up

Adam Kern et al. J Pers Med. 2021.

. 2021 Mar 6;11(3):186.

doi: 10.3390/jpm11030186.

Authors

Affiliations

¹ Department of Cardiology and Internal Medicine, Medical Faculty, University of Warmia and Mazury in Olsztyn, 10-561 Olsztyn, Poland.
² Department of Cardiology, Voivodal Specialist Hospital in Olsztyn, 10-561 Olsztyn, Poland.
³ Department of Nephrology, Hypertension and Internal Medicine, Medical Faculty, University of Warmia and Mazury in Olsztyn, 10-561 Olsztyn, Poland.
⁴ Department of Human Histology and Embryology, Medical Faculty, University of Warmia and Mazury in Olsztyn, 10-561 Olsztyn, Poland.
⁵ Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-561 Olsztyn, Poland.
⁶ Department of Anaesthesiology and Intensive Care, School of Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, 10-561 Olsztyn, Poland.
⁷ Clinical Department of Anaesthesiology and Intensive Care, Voivodal Specialist Hospital in Olsztyn, 10-561 Olsztyn, Poland.
⁸ Department of Invasive Cardiology, Centre of Postgraduate Medical Education, 02-507 Warsaw, Poland.

PMID: 33800939
PMCID: PMC8001826
DOI: 10.3390/jpm11030186

Abstract

Sclerostin might play a role in atherosclerosis development. This study aimed to analyze the impact of baseline sclerostin levels on 9-year outcomes in patients without significant renal function impairment and undergoing coronary angiography. The primary study endpoint was the rate of major cardiovascular events (MACE), defined as a combined rate of myocardial infarction (MI), stroke, or death at 9 years. We included 205 patients with a mean age of 62.9 ± 0.6 years and 70.2% male. Median serum sclerostin concentration was 133.22 pg/mL (IQR 64.0-276.17). At 9 years, in the whole population, the rate of MACE was 34.1% (n = 70), MI: 11.2% (n = 23), stroke: 2.4% (n = 5), and death: 20.5% (n = 42). In the high sclerostin (>median) group, we observed statistically significant higher rates of MACE and death: 25.2% vs. 43.1% (HR 1.75, 95% CI 1.1-2.10, p = 0.02) and 14.6% vs. 26.5% (HR 1.86, 95% CI 1.02-3.41, p = 0.049), respectively. Similar relationships were observed in patients with chronic coronary syndrome and SYNTAX 0-22 subgroups. Our results suggest that sclerostin assessment might be useful in risk stratification, and subjects with higher sclerostin levels might have a worse prognosis.

Keywords: Klotho; bone metabolism; cardiovascular events; coronary angiography; coronary artery disease; death; multivessel disease; myocardial infarction; osteocyte; sclerostin; stroke.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 2**
Whole population—Kaplan–Meier curves for MACE, myocardial infarction, and all-cause death, respectively.

**Figure 3**
Chronic coronary syndrome population—Kaplan–Meier curves for MACE, myocardial infarction, and all-cause death, respectively.

**Figure 4**
Acute coronary syndrome population—Kaplan–Meier curves for MACE, myocardial infarction, and all-cause death, respectively.

**Figure 5**
SYNTAX 0–22 population—Kaplan–Meier curves for MACE, myocardial infarction, and all-cause death, respectively.

See this image and copyright information in PMC

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[1] Dallas S.L., Prideaux M., Bonewald L.F. The osteocyte: An endocrine cell and more. Endocr. Rev. 2013;34:658–690. doi: 10.1210/er.2012-1026. - DOI - PMC - PubMed

[2] Dallas S.L., Prideaux M., Bonewald L.F. The osteocyte: An endocrine cell and more. Endocr. Rev. 2013;34:658–690. doi: 10.1210/er.2012-1026. - DOI - PMC - PubMed

[3] Tresguerres F., Torres J., López-Quiles J., Hernández G., Vega J., Tresguerres I. The osteocyte: A multifunctional cell within the bone. Ann. Anat.—Anat. Anz. 2020;227:151422. doi: 10.1016/j.aanat.2019.151422. - DOI - PubMed

[4] Tresguerres F., Torres J., López-Quiles J., Hernández G., Vega J., Tresguerres I. The osteocyte: A multifunctional cell within the bone. Ann. Anat.—Anat. Anz. 2020;227:151422. doi: 10.1016/j.aanat.2019.151422. - DOI - PubMed

[5] Carlson N., Axelsen M., Mortensen O.H., Pedersen R.S., Heaf J.G. Clearance of Sclerostin, Osteocalcin, Fibroblast Growth Factor 23, and Osteoprotegerin by Dialysis. Blood Purif. 2017;44:122–128. doi: 10.1159/000465513. - DOI - PubMed

[6] Carlson N., Axelsen M., Mortensen O.H., Pedersen R.S., Heaf J.G. Clearance of Sclerostin, Osteocalcin, Fibroblast Growth Factor 23, and Osteoprotegerin by Dialysis. Blood Purif. 2017;44:122–128. doi: 10.1159/000465513. - DOI - PubMed

[7] Andrukhova O., Slavic S., Smorodchenko A., Zeitz U., Shalhoub V., Lanske B., E Pohl E., Erben R.G. FGF 23 regulates renal sodium handling and blood pressure. EMBO Mol. Med. 2014;6:744–759. doi: 10.1002/emmm.201303716. - DOI - PMC - PubMed

[8] Andrukhova O., Slavic S., Smorodchenko A., Zeitz U., Shalhoub V., Lanske B., E Pohl E., Erben R.G. FGF 23 regulates renal sodium handling and blood pressure. EMBO Mol. Med. 2014;6:744–759. doi: 10.1002/emmm.201303716. - DOI - PMC - PubMed

[9] Delanaye P., Cavalier E., Bouquegneau A., Khwaja A. Sclerostin levels in CKD patients: An important, but not definitive, step on the way to clinical use. Kidney Int. 2015;88:1221–1223. doi: 10.1038/ki.2015.258. - DOI - PubMed

[10] Delanaye P., Cavalier E., Bouquegneau A., Khwaja A. Sclerostin levels in CKD patients: An important, but not definitive, step on the way to clinical use. Kidney Int. 2015;88:1221–1223. doi: 10.1038/ki.2015.258. - DOI - PubMed

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The Impact of Sclerostin Levels on Long-Term Prognosis in Patients Undergoing Coronary Angiography: A Personalized Approach with 9-Year Follow-Up

Affiliations

The Impact of Sclerostin Levels on Long-Term Prognosis in Patients Undergoing Coronary Angiography: A Personalized Approach with 9-Year Follow-Up

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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References

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