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Multicenter Study
. 2021 Apr 7;11(1):7570.
doi: 10.1038/s41598-021-87130-0.

Lack of association of CD44-rs353630 and CHI3L2-rs684559 with pancreatic ductal adenocarcinoma survival

Manuel Gentiluomo  1 , Chiara Corradi  1 , Giuseppe Vanella  2   3 , Astrid Z Johansen  4 , Oliver Strobel  5 , Andrea Szentesi  6   7 , Anna Caterina Milanetto  8 , Péter Hegyi  6   7 , Juozas Kupcinskas  9 , Francesca Tavano  10 , John P Neoptolemos  5 , Dania Bozzato  11 , Thilo Hackert  5 , Raffaele Pezzilli  12 , Julia S Johansen  4   13 , Eithne Costello  14 , Beatrice Mohelnikova-Duchonova  15 , Casper H J van Eijck  16 , Renata Talar-Wojnarowska  17 , Carsten Palnæs Hansen  18 , Erika Darvasi  7 , Inna M Chen  4 , Giulia Martina Cavestro  19 , Pavel Soucek  20 , Liliana Piredda  21 , Pavel Vodicka  22 , Maria Gazouli  23 , Paolo Giorgio Arcidiacono  2 , Federico Canzian  24 , Daniele Campa #  25 , Gabriele Capurso #  2   3
Affiliations
Multicenter Study

Lack of association of CD44-rs353630 and CHI3L2-rs684559 with pancreatic ductal adenocarcinoma survival

Manuel Gentiluomo et al. Sci Rep. .

Abstract

Although pancreatic ductal adenocarcinoma (PDAC) survival is poor, there are differences in patients' response to the treatments. Detection of predictive biomarkers explaining these differences is of the utmost importance. In a recent study two genetic markers (CD44-rs353630 and CHI3L2-rs684559) were reported to be associated with survival after PDAC resection. We attempted to replicate the associations in 1856 PDAC patients (685 resected with stage I/II) from the PANcreatic Disease ReseArch (PANDoRA) consortium. We also analysed the combined effect of the two genotypes in order to compare our results with what was previously reported. Additional stratified analyses considering TNM stage of the disease and whether the patients received surgery were also performed. We observed no statistically significant associations, except for the heterozygous carriers of CD44-rs353630, who were associated with worse OS (HR = 5.01; 95% CI 1.58-15.88; p = 0.006) among patients with stage I disease. This association is in the opposite direction of those reported previously, suggesting that data obtained in such small subgroups are hardly replicable and should be considered cautiously. The two polymorphisms combined did not show any statistically significant association. Our results suggest that the effect of CD44-rs353630 and CHI3L2-rs684559 cannot be generalized to all PDAC patients.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Kaplan–Meier curve showing the survival of resected PDAC patients diagnosed in stage I or II, according to the combined genotypes of CD44-rs353630 and CHI3L2-rs684559.
See this image and copyright information in PMC

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