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Review
. 2021;26(3):220-239.
doi: 10.5863/1551-6776-26.3.220. Epub 2021 Mar 31.

The Trilogy of SARS-CoV-2 in Pediatrics (Part 1): Acute COVID-19 in Special Populations

Sarah Parsons, Van L Tran
Review

The Trilogy of SARS-CoV-2 in Pediatrics (Part 1): Acute COVID-19 in Special Populations

Sarah Parsons et al. J Pediatr Pharmacol Ther. 2021.

Abstract

With the emergence of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus, the pandemic has resulted in a severe respiratory disease known as COVID-19. Data and literature are limited in the evaluation, treatment, and considerations for pediatric patients including special populations (e.g., neonates, children, immunocompromised patients, and those with sickle cell disease). There exists a need for a comprehensive review of pediatric proven and disproven treatments as therapies continue to emerge. This article evaluates the pharmacologic treatment and prevention therapies used in pediatric patients to date, including emergency use authorizations, as well as rationales for pharmacotherapies not routinely used to treat acute COVID-19 infection. It is important to note this review article is current as of January 25, 2021, given the rapid evolvement of the pandemic.

Keywords: COVID-19; SARS-CoV-2; children; pandemic; pediatric; review.

PubMed Disclaimer

Conflict of interest statement

Disclosure. The authors declare no conflict or financial interest in any product or service mentioned in the manuscript, including grants, equipment, medications, employment, gifts, and honoraria.

Figures

Figure 1.
Figure 1.
Phases of COVID-19 illness.
Figure 2.
Figure 2.
Example of outpatient pediatric treatment algorithm.
Figure 3.
Figure 3.
Example of inpatient pediatric treatment algorithm.
See this image and copyright information in PMC

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