Effectiveness of dexmedetomidine combined with high flow nasal oxygen and long periods of awake prone positioning in moderate or severe COVID-19 pneumonia

doi:10.1016/j.jclinane.2021.110261

. 2021 Sep:72:110261.

doi: 10.1016/j.jclinane.2021.110261. Epub 2021 Mar 31.

Effectiveness of dexmedetomidine combined with high flow nasal oxygen and long periods of awake prone positioning in moderate or severe COVID-19 pneumonia

Manuel Taboada¹, Aurora Baluja², Laura Dos Santos², Irene González², Sonia Veiras², Valentín Caruezo², Alberto Naveira², Paula Mirón², Carmen Novoa², Patricia Doldán², Andrea Calvo², Ana Tubio², Salomé Selas², María Eiras², Adrián Martínez², Olga Campaña², María Teresa Rodríguez², María Diaz-Vieito², Agustín Cariñena², Pablo Otero², Gumersindo Mariño², María Domínguez², Ignacio Muniategui², Francisco Aneiros², Julián Alvarez²

Affiliations

¹ Department of Anesthesiology and Intensive Care Medicine, Clinical University Hospital of Santiago. Spain. Electronic address: manuel.taboada.muniz@sergas.es.
² Department of Anesthesiology and Intensive Care Medicine, Clinical University Hospital of Santiago. Spain.

PMID: 33839432
PMCID: PMC8011721
DOI: 10.1016/j.jclinane.2021.110261

Effectiveness of dexmedetomidine combined with high flow nasal oxygen and long periods of awake prone positioning in moderate or severe COVID-19 pneumonia

Manuel Taboada et al. J Clin Anesth. 2021 Sep.

. 2021 Sep:72:110261.

doi: 10.1016/j.jclinane.2021.110261. Epub 2021 Mar 31.

Authors

Affiliations

¹ Department of Anesthesiology and Intensive Care Medicine, Clinical University Hospital of Santiago. Spain. Electronic address: manuel.taboada.muniz@sergas.es.
² Department of Anesthesiology and Intensive Care Medicine, Clinical University Hospital of Santiago. Spain.

PMID: 33839432
PMCID: PMC8011721
DOI: 10.1016/j.jclinane.2021.110261

No abstract available

Keywords: COVID-19; Dexmedetomidine; High flow nasal oxygen (HFNC); Prone positioning (PP); acute respiratory distress syndrome (ARDS).

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Conflict of interest statement

The authors declare the absence of conflict of interests.

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Prone Positioning for Patients With COVID-19-Induced Acute Hypoxemic Respiratory Failure: Flipping the Script.
Li J, Ibarra-Estrada M, Guérin C. Li J, et al. Respir Care. 2023 Oct;68(10):1449-1464. doi: 10.4187/respcare.11227. Respir Care. 2023. PMID: 37722733 Free PMC article. Review.
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Busico M, Laiz MM, Urrutia JG, Amado ME, Villalba D, Saavedra SN, Gallardo A, Thille AW. Busico M, et al. Can J Respir Ther. 2022 Sep 28;58:151-154. doi: 10.29390/cjrt-2022-035. eCollection 2022. Can J Respir Ther. 2022. PMID: 36284514 Free PMC article.
[Critical patients COVID-19 has changed the management and outcomes in the ICU after 1 year of the pandemic? A multicenter, prospective, observational study].
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References

1. Grasselli G., Greco M., Zanella A., Albano G., Antonelli M., Bellani G., et al. Risk factors associated with mortality among patients with COVID-19 in intensive care units in Lombardy, Italy. JAMA Intern Med. 2020 Oct 1;180(10):1345–1355. doi: 10.1001/jamainternmed.2020.3539. - DOI - PMC - PubMed
1. Frat J.P., Thille A.W., Mercat A., Girault C., Ragot S., Perbet S., et al. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med. 2015 Jun 4;372(23):2185–2196. doi: 10.1056/NEJMoa1503326. - DOI - PubMed
1. Mellado-Artigas R., Ferreyro B.L., Angriman F., Hernández-Sanz M., Arruti E., Torres A., et al. High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure. Crit Care. 2021 Feb 11;25(1):58. doi: 10.1186/s13054-021-03469-w. - DOI - PMC - PubMed
1. Guérin C., Reignier J., Richard J.C., Beuret P., Gacouin A., Boulain T., et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med. 2013 Jun 6;368(23):2159–2168. doi: 10.1056/NEJMoa1214103. [Epub 2013 May 20] - DOI - PubMed
1. Taboada M., González M., Álvarez A., González I., García J., Eiras M., et al. Effectiveness of prone positioning in nonintubated intensive care unit patients with moderate to severe acute respiratory distress syndrome by coronavirus disease 2019. Anesth Analg. 2021 Jan;132(1):25–30. doi: 10.1213/ANE.0000000000005239. - DOI - PMC - PubMed

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[1] Grasselli G., Greco M., Zanella A., Albano G., Antonelli M., Bellani G., et al. Risk factors associated with mortality among patients with COVID-19 in intensive care units in Lombardy, Italy. JAMA Intern Med. 2020 Oct 1;180(10):1345–1355. doi: 10.1001/jamainternmed.2020.3539. - DOI - PMC - PubMed

[2] Grasselli G., Greco M., Zanella A., Albano G., Antonelli M., Bellani G., et al. Risk factors associated with mortality among patients with COVID-19 in intensive care units in Lombardy, Italy. JAMA Intern Med. 2020 Oct 1;180(10):1345–1355. doi: 10.1001/jamainternmed.2020.3539. - DOI - PMC - PubMed

[3] Frat J.P., Thille A.W., Mercat A., Girault C., Ragot S., Perbet S., et al. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med. 2015 Jun 4;372(23):2185–2196. doi: 10.1056/NEJMoa1503326. - DOI - PubMed

[4] Frat J.P., Thille A.W., Mercat A., Girault C., Ragot S., Perbet S., et al. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med. 2015 Jun 4;372(23):2185–2196. doi: 10.1056/NEJMoa1503326. - DOI - PubMed

[5] Mellado-Artigas R., Ferreyro B.L., Angriman F., Hernández-Sanz M., Arruti E., Torres A., et al. High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure. Crit Care. 2021 Feb 11;25(1):58. doi: 10.1186/s13054-021-03469-w. - DOI - PMC - PubMed

[6] Mellado-Artigas R., Ferreyro B.L., Angriman F., Hernández-Sanz M., Arruti E., Torres A., et al. High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure. Crit Care. 2021 Feb 11;25(1):58. doi: 10.1186/s13054-021-03469-w. - DOI - PMC - PubMed

[7] Guérin C., Reignier J., Richard J.C., Beuret P., Gacouin A., Boulain T., et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med. 2013 Jun 6;368(23):2159–2168. doi: 10.1056/NEJMoa1214103. [Epub 2013 May 20] - DOI - PubMed

[8] Guérin C., Reignier J., Richard J.C., Beuret P., Gacouin A., Boulain T., et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med. 2013 Jun 6;368(23):2159–2168. doi: 10.1056/NEJMoa1214103. [Epub 2013 May 20] - DOI - PubMed

[9] Taboada M., González M., Álvarez A., González I., García J., Eiras M., et al. Effectiveness of prone positioning in nonintubated intensive care unit patients with moderate to severe acute respiratory distress syndrome by coronavirus disease 2019. Anesth Analg. 2021 Jan;132(1):25–30. doi: 10.1213/ANE.0000000000005239. - DOI - PMC - PubMed

[10] Taboada M., González M., Álvarez A., González I., García J., Eiras M., et al. Effectiveness of prone positioning in nonintubated intensive care unit patients with moderate to severe acute respiratory distress syndrome by coronavirus disease 2019. Anesth Analg. 2021 Jan;132(1):25–30. doi: 10.1213/ANE.0000000000005239. - DOI - PMC - PubMed

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Effectiveness of dexmedetomidine combined with high flow nasal oxygen and long periods of awake prone positioning in moderate or severe COVID-19 pneumonia

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Effectiveness of dexmedetomidine combined with high flow nasal oxygen and long periods of awake prone positioning in moderate or severe COVID-19 pneumonia

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