Inflammation-Induced Tumorigenesis and Metastasis

doi:10.3390/ijms22115421

Review

. 2021 May 21;22(11):5421.

doi: 10.3390/ijms22115421.

Inflammation-Induced Tumorigenesis and Metastasis

Sana Hibino¹, Tetsuro Kawazoe^{2

3}, Hidenori Kasahara^{4

5

6}, Shinji Itoh³, Takatsugu Ishimoto⁷, Mamiko Sakata-Yanagimoto⁸, Koji Taniguchi^{2

9}

Affiliations

¹ Research Center for Advanced Science and Technology, Department of Inflammology, The University of Tokyo, Tokyo 153-0041, Japan.
² Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan.
³ Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
⁴ National Center for Global Health and Medicine, Department of Stem Cell Biology, Research Institute, Tokyo 162-8655, Japan.
⁵ Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
⁶ Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.
⁷ Gastrointestinal Cancer Biology, International Research Center of Medical Sciences (IRCMS), Kumamoto University, Kumamoto 860-0811, Japan.
⁸ Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
⁹ Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.

PMID: 34063828
PMCID: PMC8196678
DOI: 10.3390/ijms22115421

Review

Inflammation-Induced Tumorigenesis and Metastasis

Sana Hibino et al. Int J Mol Sci. 2021.

. 2021 May 21;22(11):5421.

doi: 10.3390/ijms22115421.

Authors

Sana Hibino¹, Tetsuro Kawazoe^{2

3}, Hidenori Kasahara^{4

5

6}, Shinji Itoh³, Takatsugu Ishimoto⁷, Mamiko Sakata-Yanagimoto⁸, Koji Taniguchi^{2

9}

Affiliations

¹ Research Center for Advanced Science and Technology, Department of Inflammology, The University of Tokyo, Tokyo 153-0041, Japan.
² Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan.
³ Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
⁴ National Center for Global Health and Medicine, Department of Stem Cell Biology, Research Institute, Tokyo 162-8655, Japan.
⁵ Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
⁶ Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.
⁷ Gastrointestinal Cancer Biology, International Research Center of Medical Sciences (IRCMS), Kumamoto University, Kumamoto 860-0811, Japan.
⁸ Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
⁹ Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.

PMID: 34063828
PMCID: PMC8196678
DOI: 10.3390/ijms22115421

Abstract

Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and metastasis through various mechanisms and is now recognized as a hallmark of cancer and an attractive therapeutic _target in cancer. In this review, we discuss recent advances in molecular mechanisms of how inflammation promotes tumorigenesis and metastasis and suppresses anti-tumor immunity in various types of solid tumors, including esophageal, gastric, colorectal, liver, and pancreatic cancer as well as hematopoietic malignancies.

Keywords: cancer; immunosuppression; inflammation; metastasis; tumor microenvironment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Chronic inflammation promotes tumor progression.

See this image and copyright information in PMC

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References

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[1] Karin M., Clevers H. Reparative inflammation takes charge of tissue regeneration. Nature. 2016;529:307–315. doi: 10.1038/nature17039. - DOI - PMC - PubMed

[2] Karin M., Clevers H. Reparative inflammation takes charge of tissue regeneration. Nature. 2016;529:307–315. doi: 10.1038/nature17039. - DOI - PMC - PubMed

[3] Balkwill F., Mantovani A. Inflammation and cancer: Back to Virchow? Lancet. 2001;357:539–545. doi: 10.1016/S0140-6736(00)04046-0. - DOI - PubMed

[4] Balkwill F., Mantovani A. Inflammation and cancer: Back to Virchow? Lancet. 2001;357:539–545. doi: 10.1016/S0140-6736(00)04046-0. - DOI - PubMed

[5] Fujiki H. Gist of Dr. Katsusaburo Yamagiwa’s papers entitled “Experimental study on the pathogenesis of epithelial tumors” (I to VI reports) Cancer Sci. 2014;105:143–149. doi: 10.1111/cas.12333. - DOI - PMC - PubMed

[6] Fujiki H. Gist of Dr. Katsusaburo Yamagiwa’s papers entitled “Experimental study on the pathogenesis of epithelial tumors” (I to VI reports) Cancer Sci. 2014;105:143–149. doi: 10.1111/cas.12333. - DOI - PMC - PubMed

[7] Thun M.J., Henley S.J., Patrono C. Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues. J. Natl. Cancer Inst. 2002;94:252–266. doi: 10.1093/jnci/94.4.252. - DOI - PubMed

[8] Thun M.J., Henley S.J., Patrono C. Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues. J. Natl. Cancer Inst. 2002;94:252–266. doi: 10.1093/jnci/94.4.252. - DOI - PubMed

[9] Dvorak H.F. Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 1986;315:1650–1659. - PubMed

[10] Dvorak H.F. Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 1986;315:1650–1659. - PubMed

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Inflammation-Induced Tumorigenesis and Metastasis

Affiliations

Inflammation-Induced Tumorigenesis and Metastasis

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Abstract

Conflict of interest statement

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