Nuclear factor-kappa B and its role in inflammatory lung disease
- PMID: 34181887
- DOI: 10.1016/j.cbi.2021.109568
Nuclear factor-kappa B and its role in inflammatory lung disease
Abstract
Nuclear factor-kappa B, involved in inflammation, host immune response, cell adhesion, growth signals, cell proliferation, cell differentiation, and apoptosis defense, is a dimeric transcription factor. Inflammation is a key component of many common respiratory disorders, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, and acute respiratory distress syndrome. Many basic transcription factors are found in NF-κB signaling, which is a member of the Rel protein family. Five members of this family c-REL, NF-κB2 (p100/p52), RelA (p65), NF-κB1 (p105/p50), RelB, and RelA (p65) produce 5 transcriptionally active molecules. Proinflammatory cytokines, T lymphocyte, and B lymphocyte cell mitogens, lipopolysaccharides, bacteria, viral proteins, viruses, double-stranded RNA, oxidative stress, physical exertion, various chemotherapeutics are the stimulus responsible for NF-κB activation. NF-κB act as a principal component for several common respiratory illnesses, such as asthma, lung cancer, pulmonary fibrosis, COPD as well as infectious diseases like pneumonia, tuberculosis, COVID-19. Inflammatory lung disease, especially COVID-19, can make NF-κB a key _target for drug production.
Keywords: Asthma; COPD; COVID-19; Cytokines; Inflammation; Nuclear factor-kappa B.
Copyright © 2021 Elsevier B.V. All rights reserved.
Similar articles
-
Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology.Biochem J. 2004 Sep 1;382(Pt 2):393-409. doi: 10.1042/BJ20040544. Biochem J. 2004. PMID: 15214841 Free PMC article. Review.
-
NF-kappa B p100 (Lyt-10) is a component of H2TF1 and can function as an I kappa B-like molecule.Mol Cell Biol. 1993 Oct;13(10):6089-101. doi: 10.1128/mcb.13.10.6089-6101.1993. Mol Cell Biol. 1993. PMID: 8413211 Free PMC article.
-
NF-κB Transcription Factors: Their Distribution, Family Expansion, Structural Conservation, and Evolution in Animals.Int J Mol Sci. 2024 Sep 10;25(18):9793. doi: 10.3390/ijms25189793. Int J Mol Sci. 2024. PMID: 39337282 Free PMC article.
-
Hypoxia-induced activation of specific members of the NF-kB family and its relevance to pulmonary vascular remodeling.Int J Biochem Cell Biol. 2017 Nov;92:141-147. doi: 10.1016/j.biocel.2017.09.022. Epub 2017 Oct 4. Int J Biochem Cell Biol. 2017. PMID: 28987523
-
Nuclear factor-kappaB1: regulation and function.Int J Biochem Cell Biol. 2008;40(8):1425-30. doi: 10.1016/j.biocel.2007.05.004. Epub 2007 May 17. Int J Biochem Cell Biol. 2008. PMID: 17693123 Review.
Cited by
-
Pharmacological effects and the related mechanism of scutellarin on inflammation-related diseases: a review.Front Pharmacol. 2024 Aug 12;15:1463140. doi: 10.3389/fphar.2024.1463140. eCollection 2024. Front Pharmacol. 2024. PMID: 39188946 Free PMC article. Review.
-
miR‑186‑5p regulates the inflammatory response of chronic obstructive pulmonary disorder by _targeting HIF‑1α.Mol Med Rep. 2024 Feb;29(2):34. doi: 10.3892/mmr.2024.13158. Epub 2024 Jan 12. Mol Med Rep. 2024. PMID: 38214374 Free PMC article.
-
Electrochemical Biosensors Based on Carbon Nanomaterials for Diagnosis of Human Respiratory Diseases.Biosensors (Basel). 2022 Dec 22;13(1):12. doi: 10.3390/bios13010012. Biosensors (Basel). 2022. PMID: 36671847 Free PMC article. Review.
-
SIRT1 as a Potential Therapeutic _target for Chronic Obstructive Pulmonary Disease.Lung. 2023 Apr;201(2):201-215. doi: 10.1007/s00408-023-00607-9. Epub 2023 Feb 15. Lung. 2023. PMID: 36790647 Review.
-
Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo.Naunyn Schmiedebergs Arch Pharmacol. 2024 May;397(5):3301-3312. doi: 10.1007/s00210-023-02813-x. Epub 2023 Nov 6. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 37930390
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials