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. 2021 Aug 3;4(3):52.
doi: 10.3390/mps4030052.

Archive for Research in Child Health (ARCH) and Baby Gut: Study Protocol for a Remote, Prospective, Longitudinal Pregnancy and Birth Cohort to Address Microbiota Development and Child Health

Eliot N Haddad  1 , Sarah S Comstock  1
Affiliations

Archive for Research in Child Health (ARCH) and Baby Gut: Study Protocol for a Remote, Prospective, Longitudinal Pregnancy and Birth Cohort to Address Microbiota Development and Child Health

Eliot N Haddad et al. Methods Protoc. .

Abstract

The infant gut microbiome is shaped by numerous factors such as diet and the maternal microbiota and is also associated with later atopy and obesity. The Archive for Research in Child Health and Baby Gut (ARCHBG) cohort was established in 2015 to (1) understand how the development of the infant gut microbiota is associated with atopy, obesity, and gastrointestinal disease and (2) characterize the associations of maternal pre-pregnancy BMI and infant diet with the development of the gut microbiota. Study participants for ARCHBG are convenience samples recruited through two pipelines in Lansing and Traverse City, Michigan: (1) Archive for Research in Child Health (ARCHGUT) and (2) BABYGUT. A total of (n = 51) mother-infant dyads have been enrolled to date. This prospective cohort study collects maternal pre-pregnancy fecal samples, maternal data, child fecal samples at four timepoints (one week, six months, 12 months, and 24 months), and child data up to five years of age. All samples and data are collected remotely by mail, phone, or drop-off at select locations. Of all participants enrolled, 76.5% (n = 39) of infants have a complete record of stool samples. At least 88.2% (n = 45) of fecal samples were submitted at each timepoint. ARCHBG will allow for a nuanced understanding of the temporal development of the infant gut microbiome and numerous child health outcomes.

Keywords: child development; cohort; gut microbiome; human milk exposure; infancy; microbiota; pregnancy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The ARCHBG cohort is designed to study the main exposures associated with the development of the gut microbiome in infancy and how the microbiota development relates to the outcomes of obesity, atopy, and gastrointestinal disease.
Figure 2
Figure 2
Participant flowchart of mothers and infants in ARCHBG.
See this image and copyright information in PMC

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References

    1. Gohir W., Ratcliffe E.M., Sloboda D.M. Of the bugs that shape us: Maternal obesity, the gut microbiome, and long-term disease risk. Pediatr. Res. 2015;77:196–204. doi: 10.1038/pr.2014.169. - DOI - PubMed
    1. Kapourchali F.R., Cresci G.A.M. Early-Life Gut Microbiome—The Importance of Maternal and Infant Factors in Its Establishment. Nutr. Clin. Pract. 2020;35:386–405. doi: 10.1002/ncp.10490. - DOI - PubMed
    1. Brandon A.R., Shivakumar G., Lee S.C., Inrig S.J., Sadler J.Z. Ethical issues in perinatal mental health research. Curr. Opin. Psychiatry. 2009;22:601–606. doi: 10.1097/YCO.0b013e3283318e6f. - DOI - PMC - PubMed
    1. Nibbering B., Ubags N.D.J. Microbial interactions in the atopic march. Clin. Exp. Immunol. 2020;199:12–23. doi: 10.1111/cei.13398. - DOI - PMC - PubMed
    1. Silverberg J.I., Hanifin J.M. Adult eczema prevalence and associations with asthma and other health and demographic factors: A US population-based study. J. Allergy Clin. Immunol. 2013;132:1132–1138. doi: 10.1016/j.jaci.2013.08.031. - DOI - PubMed

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