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. 2022 Feb;28(2):308-310.
doi: 10.1016/j.cmi.2021.10.021. Epub 2021 Nov 10.

Persistent SARS-CoV-2 infection with repeated clinical recurrence in a patient with common variable immunodeficiency

Marta Dafne Cabañero-Navalon  1 , Victor Garcia-Bustos  2 , Paula Ruiz-Rodriguez  3 , Iñaki Comas  4 , Mireia Coscollá  3 , Llúcia Martinez-Priego  5 , José Todolí  1 , Pedro Moral Moral  1
Affiliations

Persistent SARS-CoV-2 infection with repeated clinical recurrence in a patient with common variable immunodeficiency

Marta Dafne Cabañero-Navalon et al. Clin Microbiol Infect. 2022 Feb.
No abstract available

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Figures

Fig. 1
Fig. 1
Whole-genome viral sequencing of subsequent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patient's isolates during hospital admissions. (a) Maximum-likelihood phylogeny of 191 SARS-CoV-2 genomes rooted with reference sequence from Wuhan. Bootstrap values ranging from 70 to 100 are represented in nodes as circles whose size is proportional to the value. Branches are coloured by identified PANGO lineages. Branches leading to the three sequences of interest are coloured red and marked with a red star. The scale bar indicates the number of nucleotide substitutions per site. (b) Intra-host variation along three sampling times and its corresponding Cycle threshold (Ct) values detected for N gene. Non-synonymous changes are plotted in panels on the left and synonymous changes on the right. Upper panel shows non-fixed single nucleotide polymorphisms (SNPs) in the first sample, middle panel shows non-fixed SNPs in the second sample, and lower panel shows non-fixed and fixed SNPs in the third sample.
Fig. 2
Fig. 2
Amino acid replacements in the sequenced samples and timeline of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection course in our patient. (a) Amino acid replacements found in at least one of three analysed samples indicated on a graphical representation of the SARS-CoV-2 genome. Amino acid replacements in black indicate those fixed in at least one of the samples, in grey those that only appeared transitorily but did not get fixed. Underlined amino acid replacements are the ones shared by all three sampling points. (b) Timeline of patient's clinical evolution, hospital admissions, virological studies and treatments. BAL, bronchoalveolar lavage.
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COMMUNITY 2
INTERN 9
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