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Meta-Analysis
. 2022 Jan 21;22(1):15.
doi: 10.1186/s12903-022-02044-1.

Added effect of 1% topical alendronate in intra-bony and inter-radicular defects as part of step II periodontal therapy: a systematic review with meta-analysis and trial sequential analysis

Claudia Arena  1 , Vito Carlo Alberto Caponio  1 , Khrystyna Zhurakivska  1 , Lucio Lo Russo  1 , Lorenzo Lo Muzio  1 , Giuseppe Troiano  2
Affiliations
Meta-Analysis

Added effect of 1% topical alendronate in intra-bony and inter-radicular defects as part of step II periodontal therapy: a systematic review with meta-analysis and trial sequential analysis

Claudia Arena et al. BMC Oral Health. .

Abstract

Background: This systematic review and meta-analysis aimed to investigate the role of alendronate combined with step 2 of periodontal therapy in reducing probing pocket depth, improving clinical attachment level, and reducing bone defect depth in intra-bony and inter-radicular defects.

Methods: RCTs with more than 6 months follow-up were included in this study. Risk of bias assessment was performed using the Cochrane collaboration tool. In addition, meta-analysis and trial sequential analysis were used to aggregate the available evidence.

Results: Seven studies met the inclusion criteria and were included in the systematic review. Topical application of alendronate during second step of periodontal therapy significantly improved PD and CAL.

Conclusion: Local application of alendronate may confer a beneficial effect when applied during step II of periodontal therapy even if long term studies are needed to confirm these results.

Clinical relevance: Considering the emerging role of host-inflammatory response in treatment of periodontitis and the antiresorptive and osteostimulative properties of bisphosphonates, several studies are focusing on the role of alendronate as an addition to non-surgical periodontal therapy.

Keywords: Alendronate; Meta-analysis; Non-surgical treatment; Periodontal defects; Periodontitis; Systematic review.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flow chart showing different phases of the selection process
Fig. 2
Fig. 2
Risk of bias assessment according to the Cochrane Collaboration tool
Fig. 3
Fig. 3
Meta-analysis (A) and Trial sequential analysis (B) for the effects of Alendronate therapy on PD reduction
Fig. 4
Fig. 4
Meta-analysis (A) and Trial sequential analysis (B) for the effects of Alendronate therapy on CAL gain
Fig. 5
Fig. 5
Meta-analysis (A) and Trial sequential analysis (B) for the effects of Alendronate therapy on bone defect depth reduction
See this image and copyright information in PMC

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