Association Between Serum Albumin Levels and Diabetic Peripheral Neuropathy Among Patients with Type 2 Diabetes: Effect Modification of Body Mass Index

doi:10.2147/DMSO.S347349

. 2022 Feb 22:15:527-534.

doi: 10.2147/DMSO.S347349. eCollection 2022.

Association Between Serum Albumin Levels and Diabetic Peripheral Neuropathy Among Patients with Type 2 Diabetes: Effect Modification of Body Mass Index

Ying Hu^{1

2

3}, Jiancheng Wang^{1

2

3}, Sha Zeng^{1

2

3}, Mengxia Chen^{1

2

3}, Guilin Zou^{1

2

3}, Yuxia Li^{1

2

3}, Lingyan Zhu^{1

2

3}, Jixiong Xu^{1

2

3}

Affiliations

¹ Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People's Republic of China.
² Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang, Jiangxi, 330006, People's Republic of China.
³ Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang, JIangxi, 330006, People's Republic of China.

PMID: 35228809
PMCID: PMC8881928
DOI: 10.2147/DMSO.S347349

Association Between Serum Albumin Levels and Diabetic Peripheral Neuropathy Among Patients with Type 2 Diabetes: Effect Modification of Body Mass Index

Ying Hu et al. Diabetes Metab Syndr Obes. 2022.

. 2022 Feb 22:15:527-534.

doi: 10.2147/DMSO.S347349. eCollection 2022.

Authors

Ying Hu^{1

2

3}, Jiancheng Wang^{1

2

3}, Sha Zeng^{1

2

3}, Mengxia Chen^{1

2

3}, Guilin Zou^{1

2

3}, Yuxia Li^{1

2

3}, Lingyan Zhu^{1

2

3}, Jixiong Xu^{1

2

3}

Affiliations

¹ Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People's Republic of China.
² Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang, Jiangxi, 330006, People's Republic of China.
³ Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang, JIangxi, 330006, People's Republic of China.

PMID: 35228809
PMCID: PMC8881928
DOI: 10.2147/DMSO.S347349

Abstract

Background: The role of serum albumin in the risk of diabetic peripheral neuropathy (DPN) remains unclear. This study aimed to explore the relationship between serum albumin level and DPN, and to examine any possible effect modifiers among patients with type 2 diabetes mellitus.

Methods: This cross-sectional study was conducted in Jiangxi, China, from May 2012 to December 2014. Serum albumin levels were determined in 523 subjects, and the association between serum albumin level and DPN was evaluated using linear regression models (odds ratio [OR] and corresponding 95% confidence interval [CI]).

Results: There was a significant inverse association between serum albumin level (per 1 g/L increment, OR 0.95 [95% CI 0.92-0.98]) and the risk of DPN. Accordingly, when serum albumin was assessed as quartiles, a significantly lower risk of DPN was found in participants in quartile 4 (OR 0.49 [95% CI 0.25-0.95]), compared with those in quartile 1. Consistently, higher albumin levels (≥35 g/L) were associated with decreased odds for DPN (OR 0.36 [95% CI 0.17-0.74]) compared with lower levels. Furthermore, the albumin-DPN association was significantly stronger in patients with a relatively high body mass index (BMI; ≥24 kg/m²; OR 0.91 [95% CI 0.85-0.98]) than in those with a low BMI (<24 kg/m²; OR 0.99 [95% CI 0.94-1.04]; P for interaction = 0.042).

Conclusion: These data suggest that serum albumin level could be a novel risk factor for DPN among patients with type 2 diabetes and relatively high BMI (>24 kg/m²).

Keywords: BMI; diabetic peripheral neuropathy; serum albumin; type 2 diabetes mellitus.

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Conflict of interest statement

All authors declare they do not have conflicts of interest.

Figures

**Figure 1**
Association between serum albumin levels with diabetic peripheral neuropathy in patients with type 2 diabetes mellitus*.

**Figure 2**
Association between serum albumin and diabetic peripheral neuropathy in various subgroups*.

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References

1. Polydefkis M, Griffin JW, McArthur J. New insights into diabetic polyneuropathy. JAMA. 2003;290(10):1371–1376. - PubMed
1. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414(6865):813–820. doi:10.1038/414813a - DOI - PubMed
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Grants and funding

The study was supported by funding from the following: the National Natural Science Funds of China (Nos. 81760168 and 81460018) and the National Natural Science Funds of Jiangxi Province (No. 20192BAB205031).

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[1] Polydefkis M, Griffin JW, McArthur J. New insights into diabetic polyneuropathy. JAMA. 2003;290(10):1371–1376. - PubMed

[2] Polydefkis M, Griffin JW, McArthur J. New insights into diabetic polyneuropathy. JAMA. 2003;290(10):1371–1376. - PubMed

[3] Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414(6865):813–820. doi:10.1038/414813a - DOI - PubMed

[4] Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414(6865):813–820. doi:10.1038/414813a - DOI - PubMed

[5] Balcioglu AS, Muderrisoglu H. Diabetes and cardiac autonomic neuropathy: clinical manifestations, cardiovascular consequences, diagnosis and treatment. World J Diabetes. 2015;6(1):80–91. doi:10.4239/wjd.v6.i1.80 - DOI - PMC - PubMed

[6] Balcioglu AS, Muderrisoglu H. Diabetes and cardiac autonomic neuropathy: clinical manifestations, cardiovascular consequences, diagnosis and treatment. World J Diabetes. 2015;6(1):80–91. doi:10.4239/wjd.v6.i1.80 - DOI - PMC - PubMed

[7] Barle H, Nyberg B, Essén P, et al. The synthesis rates of total liver protein and plasma albumin determined simultaneously in vivo in humans. Hepatology. 1997;25(1):154–158. - PubMed

[8] Barle H, Nyberg B, Essén P, et al. The synthesis rates of total liver protein and plasma albumin determined simultaneously in vivo in humans. Hepatology. 1997;25(1):154–158. - PubMed

[9] Fleck A, Smith G. Assessment of malnutrition in elderly patients. Lancet. 1991;337(8744):793. doi:10.1016/0140-6736(91)91412-N - DOI - PubMed

[10] Fleck A, Smith G. Assessment of malnutrition in elderly patients. Lancet. 1991;337(8744):793. doi:10.1016/0140-6736(91)91412-N - DOI - PubMed

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Association Between Serum Albumin Levels and Diabetic Peripheral Neuropathy Among Patients with Type 2 Diabetes: Effect Modification of Body Mass Index

Affiliations

Association Between Serum Albumin Levels and Diabetic Peripheral Neuropathy Among Patients with Type 2 Diabetes: Effect Modification of Body Mass Index

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