Greater Consumption of Total and Individual Lignans and Dietary Fibers Were Significantly Associated with Lowered Risk of Hip Fracture-A 1:1 Matched Case-Control Study among Chinese Elderly Men and Women

doi:10.3390/nu14051100

. 2022 Mar 5;14(5):1100.

doi: 10.3390/nu14051100.

Greater Consumption of Total and Individual Lignans and Dietary Fibers Were Significantly Associated with Lowered Risk of Hip Fracture-A 1:1 Matched Case-Control Study among Chinese Elderly Men and Women

Zhaomin Liu¹, Bailing Chen², Baolin Li³, Cheng Wang¹, Guoyi Li¹, Wenting Cao^{1

4}, Fangfang Zeng⁵, Yuming Chen^{1

6}

Affiliations

¹ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
² Department of Bone Surgery, The 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
³ Guangzhou Orthopaedics Trauma Hospital, Guangzhou 510045, China.
⁴ Department of Epidemiology, School of Public Health, Hainan Medical University, Haikou 571199, China.
⁵ Department of Epidemiology, School of Basic Medical Science, Jinan University, Guangzhou 510623, China.
⁶ Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.

PMID: 35268074
PMCID: PMC8912333
DOI: 10.3390/nu14051100

Greater Consumption of Total and Individual Lignans and Dietary Fibers Were Significantly Associated with Lowered Risk of Hip Fracture-A 1:1 Matched Case-Control Study among Chinese Elderly Men and Women

Zhaomin Liu et al. Nutrients. 2022.

. 2022 Mar 5;14(5):1100.

doi: 10.3390/nu14051100.

Authors

Zhaomin Liu¹, Bailing Chen², Baolin Li³, Cheng Wang¹, Guoyi Li¹, Wenting Cao^{1

4}, Fangfang Zeng⁵, Yuming Chen^{1

6}

Affiliations

¹ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
² Department of Bone Surgery, The 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
³ Guangzhou Orthopaedics Trauma Hospital, Guangzhou 510045, China.
⁴ Department of Epidemiology, School of Public Health, Hainan Medical University, Haikou 571199, China.
⁵ Department of Epidemiology, School of Basic Medical Science, Jinan University, Guangzhou 510623, China.
⁶ Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.

PMID: 35268074
PMCID: PMC8912333
DOI: 10.3390/nu14051100

Abstract

The study aims to examine the association of dietary intake of lignans with the risk of hip fractures in Chinese older adults. This was a 1:1 age- and gender- matched case−control study. Dietary survey was conducted by face-to-face interviews using a 79-item validated food frequency questionnaire. Habitual intake of total and individual lignans (matairesinol, secoisolariciresinol, pinoresinol, and lariciresinol) was estimated based on the available lignans databases. Conditional logistic regression was used to examine the relationship of dietary total and individual lignans, lignan-rich foods (vegetables, fruits, nuts, and cereals) and dietary fibers with the risk of hip fracture. A total of 1070 pairs of hip fracture incident cases and controls were recruited. Compared with the lowest quartile, the highest quartile group showed a reduced hip fracture risk by 76.3% (0.237, 95% CI: 0.103−0.544, Ptrend < 0.001) for total lignans, and 62.5% (0.375, 95% CI: 0.194−0.724, Ptrend = 0.001) for dietary fibers. Similar findings were observed for individual lignans, the estimated enterolactone level, as well as lignans from vegetables and nuts. We concluded that greater consumption of total and individual lignans, and lignan-rich foods were significantly associated with decreased risk of hip fracture.

Keywords: Chinese older adults; case–control study; hip fracture; lignans.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

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[1] Sambrook P., Cooper C. Osteoporosis. Lancet. 2006;367:2010–2018. doi: 10.1016/S0140-6736(06)68891-0. - DOI - PubMed

[2] Sambrook P., Cooper C. Osteoporosis. Lancet. 2006;367:2010–2018. doi: 10.1016/S0140-6736(06)68891-0. - DOI - PubMed

[3] Xia W.-B., He S.-L., Xu L., Liu A.-M., Jiang Y., Li M., Wang O., Xing X.-P., Sun Y., Cummings S.R. Rapidly increasing rates of hip fracture in Beijing, China. J. Bone Miner. Res. 2011;27:125–129. doi: 10.1002/jbmr.519. - DOI - PubMed

[4] Xia W.-B., He S.-L., Xu L., Liu A.-M., Jiang Y., Li M., Wang O., Xing X.-P., Sun Y., Cummings S.R. Rapidly increasing rates of hip fracture in Beijing, China. J. Bone Miner. Res. 2011;27:125–129. doi: 10.1002/jbmr.519. - DOI - PubMed

[5] Lagari V.S., Levis S. Phytoestrogens and bone health. Curr. Opin. Endocrinol. Diabetes Obes. 2010;17:546–553. doi: 10.1097/MED.0b013e32833f4867. - DOI - PubMed

[6] Lagari V.S., Levis S. Phytoestrogens and bone health. Curr. Opin. Endocrinol. Diabetes Obes. 2010;17:546–553. doi: 10.1097/MED.0b013e32833f4867. - DOI - PubMed

[7] Zamora-Ros R., Knaze V., Lujan-Barroso L., Kuhnle G., Mulligan A.A., Touillaud M., Slimani N., Romieu I., Powell N., Tumino R., et al. Dietary intakes and food sources of phytoestrogens in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24-hour dietary recall cohort. Eur. J. Clin. Nutr. 2012;66:932–941. doi: 10.1038/ejcn.2012.36. - DOI - PubMed

[8] Zamora-Ros R., Knaze V., Lujan-Barroso L., Kuhnle G., Mulligan A.A., Touillaud M., Slimani N., Romieu I., Powell N., Tumino R., et al. Dietary intakes and food sources of phytoestrogens in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24-hour dietary recall cohort. Eur. J. Clin. Nutr. 2012;66:932–941. doi: 10.1038/ejcn.2012.36. - DOI - PubMed

[9] Heinonen S., Nurmi T., Liukkonen K., Poutanen K., Wähälä K., Deyama T., Nishibe S., Adlercreutz H. In Vitro Metabolism of Plant Lignans: New Precursors of Mammalian Lignans Enterolactone and Enterodiol. J. Agric. Food Chem. 2001;49:3178–3186. doi: 10.1021/jf010038a. - DOI - PubMed

[10] Heinonen S., Nurmi T., Liukkonen K., Poutanen K., Wähälä K., Deyama T., Nishibe S., Adlercreutz H. In Vitro Metabolism of Plant Lignans: New Precursors of Mammalian Lignans Enterolactone and Enterodiol. J. Agric. Food Chem. 2001;49:3178–3186. doi: 10.1021/jf010038a. - DOI - PubMed

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Greater Consumption of Total and Individual Lignans and Dietary Fibers Were Significantly Associated with Lowered Risk of Hip Fracture-A 1:1 Matched Case-Control Study among Chinese Elderly Men and Women

Affiliations

Greater Consumption of Total and Individual Lignans and Dietary Fibers Were Significantly Associated with Lowered Risk of Hip Fracture-A 1:1 Matched Case-Control Study among Chinese Elderly Men and Women

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