Inhibiting BTB domain and CNC homolog 1 (Bach1) as an alternative to increase Nrf2 activation in chronic diseases
- PMID: 35292311
- DOI: 10.1016/j.bbagen.2022.130129
Inhibiting BTB domain and CNC homolog 1 (Bach1) as an alternative to increase Nrf2 activation in chronic diseases
Abstract
BTB and CNC homology 1 (Bach1) is a protein that forms nuclear heterodimers with the small musculoaponeurotic fibrosarcoma (sMaf). These bind to genomic DNA, promoting the inhibition of the synthesis of a range of antioxidant enzymes. This heterodimer antagonises the actions of nuclear factor erythroid 2-related factor-2 (Nrf2), a master regulator of cytoprotective responses in the cells. Studies have shown that Nrf2 expression is downregulated and Bach1 expression upregulated in many chronic diseases; hence Nrf2 activators and Bach1 inhibitors need to be investigated for their potential to mitigate inflammation and improve antioxidant responses in the chronic burden of lifestyle diseases, including chronic kidney disease. Thus, this review will discuss the status of Bach1 in such diseases and the use of possible inhibitors as a promising therapeutic approach.
Keywords: Bach1; Chronic kidney disease; Inflammation; Nrf2; Oxidative stress.
Copyright © 2022 Elsevier B.V. All rights reserved.
Similar articles
-
Evaluation of Bach1 mRNA expression in patients with chronic kidney disease: A preliminary study.Hemodial Int. 2023 Jul;27(3):301-307. doi: 10.1111/hdi.13084. Epub 2023 Apr 3. Hemodial Int. 2023. PMID: 37010133
-
Downregulation of Bach1 protects osteoblasts against hydrogen peroxide-induced oxidative damage in vitro by enhancing the activation of Nrf2/ARE signaling.Chem Biol Interact. 2019 Aug 25;309:108706. doi: 10.1016/j.cbi.2019.06.019. Epub 2019 Jun 11. Chem Biol Interact. 2019. PMID: 31194955
-
RANKL induces Bach1 nuclear import and attenuates Nrf2-mediated antioxidant enzymes, thereby augmenting intracellular reactive oxygen species signaling and osteoclastogenesis in mice.FASEB J. 2017 Feb;31(2):781-792. doi: 10.1096/fj.201600826R. Epub 2016 Nov 11. FASEB J. 2017. PMID: 27836987
-
Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal.FEBS J. 2023 Apr;290(7):1688-1704. doi: 10.1111/febs.16382. Epub 2022 Feb 17. FEBS J. 2023. PMID: 35107212 Review.
-
Ferroptosis regulation by Cap'n'collar family transcription factors.J Biol Chem. 2024 Aug;300(8):107583. doi: 10.1016/j.jbc.2024.107583. Epub 2024 Jul 16. J Biol Chem. 2024. PMID: 39025451 Free PMC article. Review.
Cited by
-
Carbamate compounds induced toxic effects by affecting Nrf2 signaling pathways.Toxicol Rep. 2024 Jan 6;12:148-157. doi: 10.1016/j.toxrep.2023.12.004. eCollection 2024 Jun. Toxicol Rep. 2024. PMID: 38304697 Free PMC article. Review.
-
Oxidative Stress in Chronic Obstructive Pulmonary Disease.Antioxidants (Basel). 2022 May 13;11(5):965. doi: 10.3390/antiox11050965. Antioxidants (Basel). 2022. PMID: 35624831 Free PMC article. Review.
-
Antioxidant Metabolism Pathways in Vitamins, Polyphenols, and Selenium: Parallels and Divergences.Int J Mol Sci. 2024 Feb 23;25(5):2600. doi: 10.3390/ijms25052600. Int J Mol Sci. 2024. PMID: 38473850 Free PMC article. Review.
-
Nrf2 Protein Serum Concentration in Human CKD Shows a Biphasic Behavior.Antioxidants (Basel). 2023 Apr 14;12(4):932. doi: 10.3390/antiox12040932. Antioxidants (Basel). 2023. PMID: 37107307 Free PMC article.
-
Modulation of NRF2/KEAP1 Signaling in Preeclampsia.Cells. 2023 Jun 4;12(11):1545. doi: 10.3390/cells12111545. Cells. 2023. PMID: 37296665 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous
