Controlling Immunoregulatory Cell Activity for Effective Photodynamic Therapy of Cancer

doi:10.1007/978-1-0716-2099-1_28

. 2022:2451:569-577.

doi: 10.1007/978-1-0716-2099-1_28.

Controlling Immunoregulatory Cell Activity for Effective Photodynamic Therapy of Cancer

Mladen Korbelik¹, Zdzislaw M Szulc², Alicja Bielawska², Duska Separovic³

Affiliations

¹ Department of Integrative Oncology, BC Cancer Research Centre, British Columbia Cancer Agency, Vancouver, BC, Canada. mkorbelik@bccrc.ca.
² Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
³ Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.

PMID: 35505033
DOI: 10.1007/978-1-0716-2099-1_28

Controlling Immunoregulatory Cell Activity for Effective Photodynamic Therapy of Cancer

Mladen Korbelik et al. Methods Mol Biol. 2022.

. 2022:2451:569-577.

doi: 10.1007/978-1-0716-2099-1_28.

Authors

Mladen Korbelik¹, Zdzislaw M Szulc², Alicja Bielawska², Duska Separovic³

Affiliations

¹ Department of Integrative Oncology, BC Cancer Research Centre, British Columbia Cancer Agency, Vancouver, BC, Canada. mkorbelik@bccrc.ca.
² Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
³ Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.

PMID: 35505033
DOI: 10.1007/978-1-0716-2099-1_28

Abstract

Recently, it has become clear that a prerequisite requirement for most cancer therapies is controlling the negative impact of the activity of immunosuppressory cell populations. It is therefore of a considerable interest to develop treatments for containing the operation of major myeloid and lymphoid immunoregulatory cell populations. We have reported that acid ceramidase inhibitor LCL521 effectively overrides the activity of immunoregulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) engaged in the context of tumor response to photodynamic therapy (PDT). The present communication dissects and describes in detail the procedure for the use of LCL521 as an adjuvant to PDT for improved cure rates of treated tumors based on restricting the activity of immunoregulatory cell populations.

Keywords: Ceramidase; Immunoregulatory cell populations; LCL521; Photodynamic therapy; Tumor response.

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References

1. Stewart TJ, Smyth MJ (2011) Improving cancer immunotherapy by _targeting tumor-induced immune suppression. Cancer Metastasis Rev 30:125–140 - DOI - PubMed
1. Cubillos-Ruiz JR, Mohamed E, Rodriguez PC (2017) Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer. J Immunother Cancer 5:5. https://doi.org/10.1186/s40425-016-0203-4 - DOI - PubMed - PMC
1. Baniyash M (2016) Myeloid-derived suppressor cells as intruders and _targets: clinical implications in cancer therapy. Cancer Immunol Immunother 65:857–867 - DOI - PubMed
1. Korbelik M (2018) Immunoregulatory cell populations obligatory _targets with most cancer therapies. Austin J Clin Med 5(1):1032
1. De Henau O, Rausch M, Winkler D, Campesato LF, Liu C, Hirschhorn-Cymerman D, Budhu S, Ghosh A, Pink M, Tchaicha J, Douglas M, Tibbitts T, Sharma S, Proctor J, Kosmider N, White K, Stern H, Soglia J, Adams J, Palombella VJ, McGovern K, Kutok JL, Wolchok JD, Merghoub T (2016) Overcoming resistance to checkpoint blockade therapy by _targeting PI3Kγ in myeloid cells. Nature 539:443–447

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R01 CA077475/CA/NCI NIH HHS/United States

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[1] Stewart TJ, Smyth MJ (2011) Improving cancer immunotherapy by _targeting tumor-induced immune suppression. Cancer Metastasis Rev 30:125–140 - DOI - PubMed

[2] Stewart TJ, Smyth MJ (2011) Improving cancer immunotherapy by _targeting tumor-induced immune suppression. Cancer Metastasis Rev 30:125–140 - DOI - PubMed

[3] Cubillos-Ruiz JR, Mohamed E, Rodriguez PC (2017) Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer. J Immunother Cancer 5:5. https://doi.org/10.1186/s40425-016-0203-4 - DOI - PubMed - PMC

[4] Cubillos-Ruiz JR, Mohamed E, Rodriguez PC (2017) Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer. J Immunother Cancer 5:5. https://doi.org/10.1186/s40425-016-0203-4 - DOI - PubMed - PMC

[5] Baniyash M (2016) Myeloid-derived suppressor cells as intruders and _targets: clinical implications in cancer therapy. Cancer Immunol Immunother 65:857–867 - DOI - PubMed

[6] Baniyash M (2016) Myeloid-derived suppressor cells as intruders and _targets: clinical implications in cancer therapy. Cancer Immunol Immunother 65:857–867 - DOI - PubMed

[7] Korbelik M (2018) Immunoregulatory cell populations obligatory _targets with most cancer therapies. Austin J Clin Med 5(1):1032

[8] Korbelik M (2018) Immunoregulatory cell populations obligatory _targets with most cancer therapies. Austin J Clin Med 5(1):1032

[9] De Henau O, Rausch M, Winkler D, Campesato LF, Liu C, Hirschhorn-Cymerman D, Budhu S, Ghosh A, Pink M, Tchaicha J, Douglas M, Tibbitts T, Sharma S, Proctor J, Kosmider N, White K, Stern H, Soglia J, Adams J, Palombella VJ, McGovern K, Kutok JL, Wolchok JD, Merghoub T (2016) Overcoming resistance to checkpoint blockade therapy by _targeting PI3Kγ in myeloid cells. Nature 539:443–447

[10] De Henau O, Rausch M, Winkler D, Campesato LF, Liu C, Hirschhorn-Cymerman D, Budhu S, Ghosh A, Pink M, Tchaicha J, Douglas M, Tibbitts T, Sharma S, Proctor J, Kosmider N, White K, Stern H, Soglia J, Adams J, Palombella VJ, McGovern K, Kutok JL, Wolchok JD, Merghoub T (2016) Overcoming resistance to checkpoint blockade therapy by _targeting PI3Kγ in myeloid cells. Nature 539:443–447

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Controlling Immunoregulatory Cell Activity for Effective Photodynamic Therapy of Cancer

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Controlling Immunoregulatory Cell Activity for Effective Photodynamic Therapy of Cancer

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