Home Oral Care with Biomimetic Hydroxyapatite vs. Conventional Fluoridated Toothpaste for the Remineralization and Desensitizing of White Spot Lesions: Randomized Clinical Trial

doi:10.3390/ijerph19148676

Randomized Controlled Trial

. 2022 Jul 16;19(14):8676.

doi: 10.3390/ijerph19148676.

Home Oral Care with Biomimetic Hydroxyapatite vs. Conventional Fluoridated Toothpaste for the Remineralization and Desensitizing of White Spot Lesions: Randomized Clinical Trial

Andrea Butera¹, Simone Gallo², Maurizio Pascadopoli², Mona A Montasser³, Mohammad H Abd El Latief³, Gioia Giada Modica¹, Andrea Scribante^{1

2}

Affiliations

¹ Unit of Dental Hygiene, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy.
² Unit of Orthodontics and Pediatric Dentistry, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy.
³ Department of Orthodontics, Faculty of Dentistry, Mansoura University, Mansoura 35516, Egypt.

PMID: 35886524
PMCID: PMC9317292
DOI: 10.3390/ijerph19148676

Randomized Controlled Trial

Home Oral Care with Biomimetic Hydroxyapatite vs. Conventional Fluoridated Toothpaste for the Remineralization and Desensitizing of White Spot Lesions: Randomized Clinical Trial

Andrea Butera et al. Int J Environ Res Public Health. 2022.

. 2022 Jul 16;19(14):8676.

doi: 10.3390/ijerph19148676.

Authors

Andrea Butera¹, Simone Gallo², Maurizio Pascadopoli², Mona A Montasser³, Mohammad H Abd El Latief³, Gioia Giada Modica¹, Andrea Scribante^{1

2}

Affiliations

¹ Unit of Dental Hygiene, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy.
² Unit of Orthodontics and Pediatric Dentistry, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy.
³ Department of Orthodontics, Faculty of Dentistry, Mansoura University, Mansoura 35516, Egypt.

PMID: 35886524
PMCID: PMC9317292
DOI: 10.3390/ijerph19148676

Abstract

Introduction: Biomimetic hydroxyapatite-based toothpastes have been investigated in recent years for their remineralizing activity on dental surfaces. The aim of the present study was to evaluate the efficacy of toothpaste containing biomimetic hydroxyapatite versus a 1450 pppm fluoride one in promoting the remineralization and desensitization of white spot lesions. Methods: 40 patients were randomly assigned to two different domiciliary oral hygiene treatments: toothpaste containing 1450 ppm of fluoride (control group) and toothpaste containing biomimetic hydroxyapatite (experimental group). Dental sensitivity/pain and dental erosion were assessed at baseline and after 15, 30, and 90 days using the following indexes: Schiff Air Index (SAI), Visual Analogue Scale (VAS), and Basic Erosive Wear Examination (BEWE). Results: Data were submitted for statistical analysis. SAI significantly decreased after 3 months (T3) of treatment only in the Trial group (p < 0.05). VAS values significantly decreased at T2 in the trial group (p < 0.05) with a further significant reduction at T3 (p < 0.05). BEWE scores did not significantly vary during the follow up neither in the trial nor in the control group. Conclusions: The hydroxyapatite-based toothpaste tested caused a reduction of hypersensitivity/pain values higher than conventional fluoride toothpaste.

Trial registration: ClinicalTrials.gov NCT04908293.

Keywords: biomimetic hydroxyapatite; fluoride; remineralization; toothpaste; white spot lesions.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

1. Indrapriyadharshini K., Madan Kumar P.D., Sharma K., Iyer K. Remineralizing potential of CPP-ACP in white spot lesions—A systematic review. Indian J. Dent. Res. 2018;29:487–496. doi: 10.4103/ijdr.IJDR_364_17. - DOI - PubMed
1. Julien K.C., Buschang P.H., Campbell P.M. Prevalence of white spot lesion formation during orthodontic treatment. Angle Orthod. 2013;83:641–647. doi: 10.2319/071712-584.1. - DOI - PMC - PubMed
1. Chapman J., Roberts W.E., Eckert G.J., Kula K.S., Gonzalez-Cabezas C. Risk factors for incidence and severity of white spot lesions during treatment with fixed orthodontic appliances. Am. J. Orthod. Dentofac. Orthop. 2010;138:188–194. doi: 10.1016/j.ajodo.2008.10.019. - DOI - PubMed
1. Tufekci E., Dixon J.S., Gunsolley J.C., Lindauer S.J. Prevalence of white spot lesions during orthodontic treatment with fixed appliances. Angle Orthod. 2011;2:206–210. doi: 10.2319/051710-262.1. - DOI - PMC - PubMed
1. Ballard R.W., Hagan J.L., Phaup A.N., Sarkar N., Townsend J.A., Armbruster P.C. Evaluation of 3 commercially available materials for resolution of white spot lesions. Am. J. Orthod. Dentofac. Orthop. 2013;143:S78–S84. doi: 10.1016/j.ajodo.2012.08.020. - DOI - PubMed

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[1] Indrapriyadharshini K., Madan Kumar P.D., Sharma K., Iyer K. Remineralizing potential of CPP-ACP in white spot lesions—A systematic review. Indian J. Dent. Res. 2018;29:487–496. doi: 10.4103/ijdr.IJDR_364_17. - DOI - PubMed

[2] Indrapriyadharshini K., Madan Kumar P.D., Sharma K., Iyer K. Remineralizing potential of CPP-ACP in white spot lesions—A systematic review. Indian J. Dent. Res. 2018;29:487–496. doi: 10.4103/ijdr.IJDR_364_17. - DOI - PubMed

[3] Julien K.C., Buschang P.H., Campbell P.M. Prevalence of white spot lesion formation during orthodontic treatment. Angle Orthod. 2013;83:641–647. doi: 10.2319/071712-584.1. - DOI - PMC - PubMed

[4] Julien K.C., Buschang P.H., Campbell P.M. Prevalence of white spot lesion formation during orthodontic treatment. Angle Orthod. 2013;83:641–647. doi: 10.2319/071712-584.1. - DOI - PMC - PubMed

[5] Chapman J., Roberts W.E., Eckert G.J., Kula K.S., Gonzalez-Cabezas C. Risk factors for incidence and severity of white spot lesions during treatment with fixed orthodontic appliances. Am. J. Orthod. Dentofac. Orthop. 2010;138:188–194. doi: 10.1016/j.ajodo.2008.10.019. - DOI - PubMed

[6] Chapman J., Roberts W.E., Eckert G.J., Kula K.S., Gonzalez-Cabezas C. Risk factors for incidence and severity of white spot lesions during treatment with fixed orthodontic appliances. Am. J. Orthod. Dentofac. Orthop. 2010;138:188–194. doi: 10.1016/j.ajodo.2008.10.019. - DOI - PubMed

[7] Tufekci E., Dixon J.S., Gunsolley J.C., Lindauer S.J. Prevalence of white spot lesions during orthodontic treatment with fixed appliances. Angle Orthod. 2011;2:206–210. doi: 10.2319/051710-262.1. - DOI - PMC - PubMed

[8] Tufekci E., Dixon J.S., Gunsolley J.C., Lindauer S.J. Prevalence of white spot lesions during orthodontic treatment with fixed appliances. Angle Orthod. 2011;2:206–210. doi: 10.2319/051710-262.1. - DOI - PMC - PubMed

[9] Ballard R.W., Hagan J.L., Phaup A.N., Sarkar N., Townsend J.A., Armbruster P.C. Evaluation of 3 commercially available materials for resolution of white spot lesions. Am. J. Orthod. Dentofac. Orthop. 2013;143:S78–S84. doi: 10.1016/j.ajodo.2012.08.020. - DOI - PubMed

[10] Ballard R.W., Hagan J.L., Phaup A.N., Sarkar N., Townsend J.A., Armbruster P.C. Evaluation of 3 commercially available materials for resolution of white spot lesions. Am. J. Orthod. Dentofac. Orthop. 2013;143:S78–S84. doi: 10.1016/j.ajodo.2012.08.020. - DOI - PubMed

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Home Oral Care with Biomimetic Hydroxyapatite vs. Conventional Fluoridated Toothpaste for the Remineralization and Desensitizing of White Spot Lesions: Randomized Clinical Trial

Affiliations

Home Oral Care with Biomimetic Hydroxyapatite vs. Conventional Fluoridated Toothpaste for the Remineralization and Desensitizing of White Spot Lesions: Randomized Clinical Trial

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Abstract

Conflict of interest statement

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Conflict of interest statement

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