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Review
. 2022 Nov 16;27(22):7933.
doi: 10.3390/molecules27227933.

Citroflavonoids as Promising Agents for Drug Discovery in Diabetes and Hypertension: A Systematic Review of Experimental Studies

Rolffy Ortiz-Andrade  1 , Jesús Alfredo Araujo León  2 , Juan Carlos Sánchez-Salgado  3 , Amanda Sánchez-Recillas  1 , Priscila Vazquez-Garcia  1 , Emanuel Hernández-Núñez  4
Affiliations
Review

Citroflavonoids as Promising Agents for Drug Discovery in Diabetes and Hypertension: A Systematic Review of Experimental Studies

Rolffy Ortiz-Andrade et al. Molecules. .

Abstract

Flavonoids are naturally occurring compounds widely distributed in the Citrus genus. These natural compounds have many health benefits, mainly for metabolic and cardiovascular diseases. In fact, some these compounds are components of drug products with approved indications for peripheral vascular insufficiency and hemorrhoids. However, information on pharmacological effects of these compounds remains disperse and there is scarce comprehensive analysis of whole data and evidence. These kinds of evidence analyses could be necessary in drug design and the development of novel and innovate drug products in diabetes and hypertension. We aimed to systematically search for evidence on the efficacy of citroflavonoids in diabetes and hypertension in in vivo models. We searched four literature databases based on a PICO strategy. After database curation, twenty-nine articles were retrieved to analyze experimental data. There was high heterogeneity in both outcomes and methodology. Naringenin and hesperetin derivates were the most studied citroflavonoids in both experimental models. More investigation is still needed to determine its potential for drug design and development.

Keywords: biochemical parameters; blood markers; gene expression; hesperidin; naringenin; protein content.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flowchart of the selection process of articles that fulfilled the criteria.
Figure 2
Figure 2
Chemical structures of the citroflavonoids were found in selected articles of the systematic searching; (a) aglycones, (b) glycosides. Sketched structures were designed by ChemDraw Professional 20 software (PerkinElmer, Inc., Waltham, MA, USA).
Figure 3
Figure 3
Graphic representation of the methodological process applied to perform this systematic review.
See this image and copyright information in PMC

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