Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Nov 21;8(11):e11738.
doi: 10.1016/j.heliyon.2022.e11738. eCollection 2022 Nov.

Decreased resistin plasmatic concentrations in patients with Alzheimer's disease: A case-control study

Affiliations

Decreased resistin plasmatic concentrations in patients with Alzheimer's disease: A case-control study

Andrea Marcinnò et al. Heliyon. .

Abstract

Previous studies suggested a role for adipokines in ageing and in several age-related diseases. The purpose of our study was to further elucidate adipokines involvement in neurodegeneration, investigating adiponectin, leptin and resistin in Alzheimer's disease (AD) and Frontotemporal Dementia (FTD). We enrolled for the study 70 subjects: 26 AD, 21 FTD, and 23 with other neurological (but not neurodegenerative) conditions (CTR, control group). According to a standardized protocol, we measured adipokines plasmatic levels, blood parameters of glucidic and lipidic metabolism, ESR, cerebrospinal fluid (CSF) markers of neurodegeneration (beta-amyloid, total-Tau, phosphorylated-Tau) and anthropometric parameters. In comparison with control group, we found lower resistin concentrations in patients with dementia, and in particular in AD (p < 0.001). In multivariate analysis, AD relative risk was reduced by resistin, when controlling for sex, age and anthropometric/metabolic parameters (RR = 0.71, P < 0.0001). Considering CSF biomarkers, we found a direct correlation between resistin and Aβ1-42 CSF concentration in patients (p < 0.001, r = 0.50). Lower resistin characterized AD patients in our study and AD, but not FTD, diagnosis risk was found to be inversely associated with resistin when controlling for confounders. We hypothesize that resistin-linked metabolic profile has to be reconsidered and further investigated in AD.

Keywords: Adipokines; Adiponectin; Alzheimer's disease; Frontotemporal dementia; Leptin; Resistin.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Resistin plasmatic concentrations in study groups. Box plot represents median, interquartile range and range (maximum–minimum) of resistin plasmatic concentration (ng/mL) of patients with AD, patients with FTD, and controls (CTR). ∗∗ (p < 0.01).
Figure 2
Figure 2
Resistin values correlate with Aβ1-42 CSF concentrations in AD and FTD patients. Scatter plot represents the correlation between resistin plasmatic and Aβ1-42 CSF concentrations in patients (AD and FTD). The graphed line approximates the corresponding regression line (slope coefficient ±standard deviation: 23.0 ± 5.90).

Similar articles

Cited by

References

    1. Prince M., Bryce R., Albanese E., Wimo A., Ribeiro W., Ferri C.P. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013;9(1):63–75. - PubMed
    1. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 2005;115(5):911–919. - PubMed
    1. Blüher M., Mantzoros C.S. From leptin to other adipokines in health and disease: facts and expectations at the beginning of the 21st century. Metabolism. 2015;64(1):131–145. - PubMed
    1. Fasshauer M., Blüher M. Adipokines in health and disease. Trends Pharmacol. Sci. 2015;36(7):461–470. - PubMed
    1. Lee K.S., Chung J.H., Choi T.K., Suh S.Y., Oh B.H., Hong C.H. Peripheral cytokines and chemokines in Alzheimer’s disease. Dement. Geriatr. Cognit. Disord. 2009;28(4):281–287. - PubMed

LinkOut - more resources

  NODES
Association 2
twitter 2