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. 2022 Dec 13;17(12):e0277729.
doi: 10.1371/journal.pone.0277729. eCollection 2022.

Association of liver fibrosis biomarkers with overall and CVD mortality in the Korean population: The Dong-gu study

Seong-Woo Choi  1 , Sun-Seog Kweon  2 , Young-Hoon Lee  3 , So-Yeon Ryu  1 , Hae-Sung Nam  4 , Min-Ho Shin  2
Affiliations

Association of liver fibrosis biomarkers with overall and CVD mortality in the Korean population: The Dong-gu study

Seong-Woo Choi et al. PLoS One. .

Abstract

This study evaluated the associations of liver fibrosis biomarkers [non-alcoholic fatty liver disease fibrosis score (NFS), fibrosis-4 (FIB-4), aspartate aminotransferase/platelet ratio index (APRI), and BARD score] with mortality in Korean adults aged ≥50 years. We analyzed 7,702 subjects who participated in Dong-gu Study. The associations of liber fibrosis biomarkers with mortality were investigated using Cox proportional hazards models. Overall mortality increased with increasing NFS level [adjusted hazard ratio (aHR) 4.3, 95% confidence interval (CI) 3.3-5.5 for high risk vs. low risk], increasing FIB-4 level (aHR 3.5, 95% CI 2.9-4.4 for high risk vs. low risk), and increasing APRI level (aHR 3.5, 95% CI 2.1-5.8 for high risk vs. low risk) but not with BARD score. The Harrell's concordance index for overall mortality for the NFS and FIB-4 was greater than that for the APRI and BARD score. In conclusion, NFS, FIB-4, and APRI showed a significant relationship with the overall mortality, and NFS and FIB-4 showed a significant relationship with the CVD mortality after adjustment for covariates. In addition, the NFS and FIB-4 were more predictive of overall mortality than the APRI and BARD score in Korean adults aged ≥50 years.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Kaplan-Meier survival estimates between NFS, FIB-4, APRI, and BARD score for overall mortality.
Fig 2
Fig 2. Adjusted hazard ratios of FIB-4 for overall mortality according to the BMI level.
See this image and copyright information in PMC

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References

    1. Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease—Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 2016;64(1):73–84. doi: 10.1002/hep.28431 - DOI - PubMed
    1. Li J, Zou B, Yeo YH, Feng Y, Xie X, Lee DH, et al.. Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999–2019: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 2019;4(5):389–398. doi: 10.1016/S2468-1253(19)30039-1 - DOI - PubMed
    1. Sebastiani G, Gkouvatsos K, Plebani M. Non-invasive assessment of liver fibrosis: it is time for laboratory medicine. Clin Chem Lab Med 2011;49(1):13–32. doi: 10.1515/CCLM.2011.001 - DOI - PubMed
    1. Sun W, Cui H, Li N, Wei Y, Lai S, Yang Y, et al.. Comparison of FIB-4 index, NAFLD fibrosis score and BARD score for prediction of advanced fibrosis in adult patients with non-alcoholic fatty liver disease: A meta-analysis study. Hepatol Res 2016;46(9):862–870. doi: 10.1111/hepr.12647 - DOI - PubMed
    1. Aykut UE, Akyuz U, Yesil A, Eren F, Gerin F, Ergelen R, et al.. A comparison of FibroMeter™ NAFLD Score, NAFLD fibrosis score, and transient elastography as noninvasive diagnostic tools for hepatic fibrosis in patients with biopsy-proven non-alcoholic fatty liver disease. Scand J Gastroenterol 2014;49(11):1343–1348. doi: 10.3109/00365521.2014.958099 - DOI - PubMed

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The authors received no specific funding for this work.
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