Emerging role of small GTPases and their interactome in plants to combat abiotic and biotic stress

doi:10.1007/s00709-022-01830-6

Review

. 2023 Jul;260(4):1007-1029.

doi: 10.1007/s00709-022-01830-6. Epub 2022 Dec 16.

Emerging role of small GTPases and their interactome in plants to combat abiotic and biotic stress

Jahanvi Ganotra¹, Bhawana Sharma¹, Brijesh Biswal¹, Deepak Bhardwaj², Narendra Tuteja³

Affiliations

¹ Department of Botany, Central University of Jammu, Jammu and Kashmir, Jammu, 181143, India.
² Department of Botany, Central University of Jammu, Jammu and Kashmir, Jammu, 181143, India. dbhardwajpmb@gmail.com.
³ Plant Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India. narendratuteja@gmail.com.

PMID: 36525153
DOI: 10.1007/s00709-022-01830-6

Review

Emerging role of small GTPases and their interactome in plants to combat abiotic and biotic stress

Jahanvi Ganotra et al. Protoplasma. 2023 Jul.

. 2023 Jul;260(4):1007-1029.

doi: 10.1007/s00709-022-01830-6. Epub 2022 Dec 16.

Authors

Jahanvi Ganotra¹, Bhawana Sharma¹, Brijesh Biswal¹, Deepak Bhardwaj², Narendra Tuteja³

Affiliations

¹ Department of Botany, Central University of Jammu, Jammu and Kashmir, Jammu, 181143, India.
² Department of Botany, Central University of Jammu, Jammu and Kashmir, Jammu, 181143, India. dbhardwajpmb@gmail.com.
³ Plant Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India. narendratuteja@gmail.com.

PMID: 36525153
DOI: 10.1007/s00709-022-01830-6

Abstract

Plants are frequently subjected to abiotic and biotic stress which causes major impediments in their growth and development. It is emerging that small guanosine triphosphatases (small GTPases), also known as monomeric GTP-binding proteins, assist plants in managing environmental stress. Small GTPases function as tightly regulated molecular switches that get activated with the aid of guanosine triphosphate (GTP) and deactivated by the subsequent hydrolysis of GTP to guanosine diphosphate (GDP). All small GTPases except Rat sarcoma (Ras) are found in plants, including Ras-like in brain (Rab), Rho of plant (Rop), ADP-ribosylation factor (Arf) and Ras-like nuclear (Ran). The members of small GTPases in plants interact with several downstream effectors to counteract the negative effects of environmental stress and disease-causing pathogens. In this review, we describe processes of stress alleviation by developing pathways involving several small GTPases and their associated proteins which are important for neutralizing fungal infections, stomatal regulation, and activation of abiotic stress-tolerant genes in plants. Previous reviews on small GTPases in plants were primarily focused on Rab GTPases, abiotic stress, and membrane trafficking, whereas this review seeks to improve our understanding of the role of all small GTPases in plants as well as their interactome in regulating mechanisms to combat abiotic and biotic stress. This review brings to the attention of scientists recent research on small GTPases so that they can employ genome editing tools to precisely engineer economically important plants through the overexpression/knock-out/knock-in of stress-related small GTPase genes.

Keywords: Abiotic and biotic stress; Cell signaling and resistance; GTPase activating proteins; Guanine nucleotide dissociation inhibitors; Monomeric GTP-binding proteins.

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References

1. Agarwal PK, Agarwal P, Jain P, Jha B, Reddy MK, Sopory SK (2008) Constitutive overexpression of a stress-inducible small GTP-binding protein PgRab7 from Pennisetum glaucum enhances abiotic stress tolerance in transgenic tobacco. Plant Cell Rep 27(1):105–115. https://doi.org/10.1007/s00299-007-0446-0 - DOI - PubMed
1. Akamatsu A, Wong HL, Fujiwara M, Okuda J, Nishide K, Uno K, Imai K, Umemura K, Kawasaki T, Kawano Y, Shimamoto K (2013) An OsCEBiP/OsCERK1-OsRacGEF1-OsRac1 module is an essential early component of chitin-induced rice immunity. Cell Host Microbe 13(4):465–476. https://doi.org/10.1016/j.chom.2013.03.007 - DOI - PubMed
1. Akashi K, Yoshimura K, Kajikawa M, Hanada K, Kosaka R, Kato A, Katoh A, Nanasato Y, Tsujimoto H, Yokota A (2016) Potential involvement of drought-induced Ran GTPase CLRan1 in root growth enhancement in a xerophyte wild watermelon. Biosci Biotechnol Biochem 80(10):1907–1916. https://doi.org/10.1080/09168451.2016.1191328 - DOI - PubMed
1. Al-Zahrani HS, Moussa TA, Alsamadany H, Hafez RM, Fuller MP (2022) Phylogenetic and Expression Studies of Small GTP-Binding Proteins in Solanum lycopersicum Super Strain B. Plants 11(5):641. https://doi.org/10.3390/plants11050641 - DOI - PubMed - PMC
1. Ambastha V, Matityahu I, Tidhar D, Leshem Y (2021) RabA2b overexpression alters the plasma-membrane proteome and improves drought tolerance in Arabidopsis. Front Plant Sci 2021:2222. https://doi.org/10.3389/fpls.2021.738694 - DOI

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[1] Agarwal PK, Agarwal P, Jain P, Jha B, Reddy MK, Sopory SK (2008) Constitutive overexpression of a stress-inducible small GTP-binding protein PgRab7 from Pennisetum glaucum enhances abiotic stress tolerance in transgenic tobacco. Plant Cell Rep 27(1):105–115. https://doi.org/10.1007/s00299-007-0446-0 - DOI - PubMed

[2] Agarwal PK, Agarwal P, Jain P, Jha B, Reddy MK, Sopory SK (2008) Constitutive overexpression of a stress-inducible small GTP-binding protein PgRab7 from Pennisetum glaucum enhances abiotic stress tolerance in transgenic tobacco. Plant Cell Rep 27(1):105–115. https://doi.org/10.1007/s00299-007-0446-0 - DOI - PubMed

[3] Akamatsu A, Wong HL, Fujiwara M, Okuda J, Nishide K, Uno K, Imai K, Umemura K, Kawasaki T, Kawano Y, Shimamoto K (2013) An OsCEBiP/OsCERK1-OsRacGEF1-OsRac1 module is an essential early component of chitin-induced rice immunity. Cell Host Microbe 13(4):465–476. https://doi.org/10.1016/j.chom.2013.03.007 - DOI - PubMed

[4] Akamatsu A, Wong HL, Fujiwara M, Okuda J, Nishide K, Uno K, Imai K, Umemura K, Kawasaki T, Kawano Y, Shimamoto K (2013) An OsCEBiP/OsCERK1-OsRacGEF1-OsRac1 module is an essential early component of chitin-induced rice immunity. Cell Host Microbe 13(4):465–476. https://doi.org/10.1016/j.chom.2013.03.007 - DOI - PubMed

[5] Akashi K, Yoshimura K, Kajikawa M, Hanada K, Kosaka R, Kato A, Katoh A, Nanasato Y, Tsujimoto H, Yokota A (2016) Potential involvement of drought-induced Ran GTPase CLRan1 in root growth enhancement in a xerophyte wild watermelon. Biosci Biotechnol Biochem 80(10):1907–1916. https://doi.org/10.1080/09168451.2016.1191328 - DOI - PubMed

[6] Akashi K, Yoshimura K, Kajikawa M, Hanada K, Kosaka R, Kato A, Katoh A, Nanasato Y, Tsujimoto H, Yokota A (2016) Potential involvement of drought-induced Ran GTPase CLRan1 in root growth enhancement in a xerophyte wild watermelon. Biosci Biotechnol Biochem 80(10):1907–1916. https://doi.org/10.1080/09168451.2016.1191328 - DOI - PubMed

[7] Al-Zahrani HS, Moussa TA, Alsamadany H, Hafez RM, Fuller MP (2022) Phylogenetic and Expression Studies of Small GTP-Binding Proteins in Solanum lycopersicum Super Strain B. Plants 11(5):641. https://doi.org/10.3390/plants11050641 - DOI - PubMed - PMC

[8] Al-Zahrani HS, Moussa TA, Alsamadany H, Hafez RM, Fuller MP (2022) Phylogenetic and Expression Studies of Small GTP-Binding Proteins in Solanum lycopersicum Super Strain B. Plants 11(5):641. https://doi.org/10.3390/plants11050641 - DOI - PubMed - PMC

[9] Ambastha V, Matityahu I, Tidhar D, Leshem Y (2021) RabA2b overexpression alters the plasma-membrane proteome and improves drought tolerance in Arabidopsis. Front Plant Sci 2021:2222. https://doi.org/10.3389/fpls.2021.738694 - DOI

[10] Ambastha V, Matityahu I, Tidhar D, Leshem Y (2021) RabA2b overexpression alters the plasma-membrane proteome and improves drought tolerance in Arabidopsis. Front Plant Sci 2021:2222. https://doi.org/10.3389/fpls.2021.738694 - DOI

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Emerging role of small GTPases and their interactome in plants to combat abiotic and biotic stress

Affiliations

Emerging role of small GTPases and their interactome in plants to combat abiotic and biotic stress

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