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Case Reports
. 2023 Mar 1;62(5):739-743.
doi: 10.2169/internalmedicine.1085-22. Epub 2022 Dec 21.

The Effect of Acotiamide on Nausea as a Symptom of Chronic Nausea and Vomiting Syndrome after Coronavirus Disease 2019

Toshihiko Kakiuchi  1 , Masato Yoshiura  1
Affiliations
Case Reports

The Effect of Acotiamide on Nausea as a Symptom of Chronic Nausea and Vomiting Syndrome after Coronavirus Disease 2019

Toshihiko Kakiuchi et al. Intern Med. .

Abstract

Chronic nausea and vomiting syndrome (CNVS), one of a functional gastroduodenal disorder, was identified in an 8-year-old girl and a 13-year-old boy who had complained of nausea for more than 4 months following coronavirus disease 2019 (COVID-19) due to normality of their head computed tomography and upper gastrointestinal tract images. The patients' symptoms responded quickly to acotiamide, a medication that is effective for treating functional dyspepsia (FD). Despite being a distinct illness from FD, CNVS is also a functional gastrointestinal disorder, and acotiamide may be just as effective for CNVS following COVID-19 as for FD.

Keywords: acotiamide; chronic nausea and vomiting syndrome; coronavirus disease 2019.

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Conflict of interest statement

The authors state that they have no Conflict of Interest (COI).

Figures

Figure 1.
Figure 1.
Clinical course of the two patients: (A) Case 1 and (B) Case 2. COVID-19: coronavirus disease 2019, EGD: esophagogastroduodenoscopy, CT: computed tomography, US: ultrasonography, VAS: visual analogue scale
Figure 2.
Figure 2.
Esophagogastroduodenoscopy revealed no remarkable abnormalities (A) in the esophagus or (B) the stomach.
See this image and copyright information in PMC

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