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Review
. 2023 Jan 7;29(1):43-60.
doi: 10.3748/wjg.v29.i1.43.

Current status and future perspectives of radiomics in hepatocellular carcinoma

Joao Miranda  1 , Natally Horvat  2 , Gilton Marques Fonseca  3 , Jose de Arimateia Batista Araujo-Filho  4 , Maria Clara Fernandes  2 , Charlotte Charbel  2 , Jayasree Chakraborty  5 , Fabricio Ferreira Coelho  3 , Cesar Higa Nomura  6 , Paulo Herman  7
Affiliations
Review

Current status and future perspectives of radiomics in hepatocellular carcinoma

Joao Miranda et al. World J Gastroenterol. .

Abstract

Given the frequent co-existence of an aggressive tumor and underlying chronic liver disease, the management of hepatocellular carcinoma (HCC) patients requires experienced multidisciplinary team discussion. Moreover, imaging plays a key role in the diagnosis, staging, restaging, and surveillance of HCC. Currently, imaging assessment of HCC entails the assessment of qualitative characteristics which are prone to inter-reader variability. Radiomics is an emerging field that extracts high-dimensional mineable quantitative features that cannot be assessed visually with the naked eye from medical imaging. The main potential applications of radiomic models in HCC are to predict histology, response to treatment, genetic signature, recurrence, and survival. Despite the encouraging results to date, there are challenges and limitations that need to be overcome before radiomics implementation in clinical practice. The purpose of this article is to review the main concepts and challenges pertaining to radiomics, and to review recent studies and potential applications of radiomics in HCC.

Keywords: Hepatocellular carcinoma; Radiology; Radiomics; Texture analysis.

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Conflict of interest statement

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Figures

Figure 1
Figure 1
Illustration summarizing radiomics workflow.
Figure 2
Figure 2
Illustration of hepatocellular carcinoma segmentation. 72-year-old man with cirrhosis had a new liver lesion on computed tomography, indeterminate. Gadoxetic acid-enhanced T1-weighted images show a 1.3 cm (arrows) lesion. A: With arterial phase hyperenhancement; B: Questionable washout appearance on portal venous; C: Delayed phases; D: Hypointensity on during hepatobiliary phase (20 min); E and F: A tumor bed segmentation was exemplified, the portal venous phase (E) was used to manually segment the volume of interest (F); G and H: Note the gross findings after surgery. Histology confirmed hepatocellular carcinoma.
See this image and copyright information in PMC

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