Successful Autologous Bone Marrow Transplantation in Active COVID-19 Patients: Case Report

doi:10.1016/j.transproceed.2023.02.032

Case Reports

. 2023 Apr;55(3):543-546.

doi: 10.1016/j.transproceed.2023.02.032. Epub 2023 Feb 27.

Successful Autologous Bone Marrow Transplantation in Active COVID-19 Patients: Case Report

Riad Amer¹, Ali Sabateen², Yousef El-Hamshary³, Husam Salameh⁴, Basel Hroub², Hazem Sawalhi⁵, Osama Sawalmeh²

Affiliations

¹ Hemato-oncology unit, Internal Medicine Department, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine. Electronic address: Riadamer@najah.edu.
² Internal Medicine Department, An-Najah National University Hospital, Nablus, Palestine.
³ Internal Medicine Department, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine.
⁴ Hemato-oncology unit, Internal Medicine Department, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine.
⁵ and Laboratory Department, An-Najah National University Hospital, Nablus, Palestine.

PMID: 36967338
PMCID: PMC9968609
DOI: 10.1016/j.transproceed.2023.02.032

Case Reports

Successful Autologous Bone Marrow Transplantation in Active COVID-19 Patients: Case Report

Riad Amer et al. Transplant Proc. 2023 Apr.

. 2023 Apr;55(3):543-546.

doi: 10.1016/j.transproceed.2023.02.032. Epub 2023 Feb 27.

Authors

Riad Amer¹, Ali Sabateen², Yousef El-Hamshary³, Husam Salameh⁴, Basel Hroub², Hazem Sawalhi⁵, Osama Sawalmeh²

Affiliations

¹ Hemato-oncology unit, Internal Medicine Department, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine. Electronic address: Riadamer@najah.edu.
² Internal Medicine Department, An-Najah National University Hospital, Nablus, Palestine.
³ Internal Medicine Department, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine.
⁴ Hemato-oncology unit, Internal Medicine Department, An-Najah National University Hospital, An-Najah National University, Nablus, Palestine.
⁵ and Laboratory Department, An-Najah National University Hospital, Nablus, Palestine.

PMID: 36967338
PMCID: PMC9968609
DOI: 10.1016/j.transproceed.2023.02.032

Abstract

Background: Patients with hematologic malignancies are considered at high risk for COVID-19 infection either from the disease or the treatment. Hematopoietic stem cell transplantation, one of the approved therapies for hematologic malignancies, was performed worldwide during the COVID-19 era with some regulations, such as COVID-19 testing, before proceeding with transplantation or cellular therapy. To the authors' knowledge, none have reported the result of autologous hematopoietic stem cell transplantation in an active COVID-19 patient.

Case presentation: We describe a successful clinical course of autologous bone marrow transplantation for 2 lymphoma patients who tested positive for COVID-19. A thorough discussion was conducted between multidisciplinary hemato-oncology, intensive care, and infectious diseases teams. The decision was to proceed toward bone marrow transplantation with some modifications in the transplantation protocol and close patient monitoring.

Conclusion: Our cases lend credence that successful autologous bone marrow transplantation is possible among active COVID-19 patients. The obstacles we faced could be overcome with collaboration between a highly qualified multidisciplinary team. Despite the potential complications, the benefits of bone marrow transplantation among patients with a high risk of relapse and who are still COVID-19-positive outweigh the risks. However, further studies are still recommended to support our inference.

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Chen X, Wu T, Bu Y, Yan H, Lin Q. Chen X, et al. Int J Mol Sci. 2024 Jul 17;25(14):7810. doi: 10.3390/ijms25147810. Int J Mol Sci. 2024. PMID: 39063052 Free PMC article. Review.

References

1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727–733. - PMC - PubMed
1. Shahzad M, Chaudhary SG, Zafar MU, Hassan MA, Hussain A, Ali F, et al. Impact of COVID-19 in hematopoietic stem cell transplant recipients: a systematic review and meta-analysis. Transpl Infect Dis. 2022;24:e13792. - PubMed
1. Amer A, Dweekat M, Sawalmeh O, Dweikat A, Abdoh Q. Recommendations and algorithms to deal with gastroenterological procedures, inflammatory bowel diseases, liver diseases and transplantation during COVID-19 pandemic: review article and regional expert opinion. Pal Med Pharm J. 2020;6:161–172.
1. Cucinotta D, Vanelli M. WHO declares COVID-19 a pandemic. Acta Bio Medica. 2020;91:157. - PMC - PubMed
1. Vijenthira A, Gong IY, Fox TA, Booth S, Cook G, Fattizzo B, et al. Outcomes of patients with hematologic malignancies and COVID-19: a systematic review and meta-analysis of 3377 patients. Blood. 2020;136:2881–2892. - PMC - PubMed

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[1] Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727–733. - PMC - PubMed

[2] Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727–733. - PMC - PubMed

[3] Shahzad M, Chaudhary SG, Zafar MU, Hassan MA, Hussain A, Ali F, et al. Impact of COVID-19 in hematopoietic stem cell transplant recipients: a systematic review and meta-analysis. Transpl Infect Dis. 2022;24:e13792. - PubMed

[4] Shahzad M, Chaudhary SG, Zafar MU, Hassan MA, Hussain A, Ali F, et al. Impact of COVID-19 in hematopoietic stem cell transplant recipients: a systematic review and meta-analysis. Transpl Infect Dis. 2022;24:e13792. - PubMed

[5] Amer A, Dweekat M, Sawalmeh O, Dweikat A, Abdoh Q. Recommendations and algorithms to deal with gastroenterological procedures, inflammatory bowel diseases, liver diseases and transplantation during COVID-19 pandemic: review article and regional expert opinion. Pal Med Pharm J. 2020;6:161–172.

[6] Amer A, Dweekat M, Sawalmeh O, Dweikat A, Abdoh Q. Recommendations and algorithms to deal with gastroenterological procedures, inflammatory bowel diseases, liver diseases and transplantation during COVID-19 pandemic: review article and regional expert opinion. Pal Med Pharm J. 2020;6:161–172.

[7] Cucinotta D, Vanelli M. WHO declares COVID-19 a pandemic. Acta Bio Medica. 2020;91:157. - PMC - PubMed

[8] Cucinotta D, Vanelli M. WHO declares COVID-19 a pandemic. Acta Bio Medica. 2020;91:157. - PMC - PubMed

[9] Vijenthira A, Gong IY, Fox TA, Booth S, Cook G, Fattizzo B, et al. Outcomes of patients with hematologic malignancies and COVID-19: a systematic review and meta-analysis of 3377 patients. Blood. 2020;136:2881–2892. - PMC - PubMed

[10] Vijenthira A, Gong IY, Fox TA, Booth S, Cook G, Fattizzo B, et al. Outcomes of patients with hematologic malignancies and COVID-19: a systematic review and meta-analysis of 3377 patients. Blood. 2020;136:2881–2892. - PMC - PubMed

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Successful Autologous Bone Marrow Transplantation in Active COVID-19 Patients: Case Report

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Successful Autologous Bone Marrow Transplantation in Active COVID-19 Patients: Case Report

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